- Min.Order :1 Gram
- Purity: 99
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Keywords
Sermaglutide C187H291N45O59 Sermaglutide USP/EP/BP
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- Appearance:White Powder
- Application:Breast cancer diagnosis, Tumor imaging
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- ProductionCapacity:200|Kilogram|Year
- Storage:-20°C
- Transportation:By air
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Brief introduction
Somarlutide, developed by Novo Nordisk and marketed under the Ozempic, Wegovy and Rybelsus brand names, is an anti-diabetic drug for the treatment of type 2 diabetes and an anti-obesity drug for long-term weight management.
Peptides can be administered by subcutaneous injection or orally.
In 2020, it was the 129th most commonly used drug in the United States, with more than 4 million prescriptions written.
Indications and uses
Somarlutide can be used as an adjunctive to diet and exercise to improve blood sugar control in adults with type 2 diabetes and to increase physical activity for chronic weight loss
The initial body mass index (BMI) is the management of the following adults:
30 kg/m2 or above (obese) or
27 kg/m2 or higher (overweight) with at least one weight-related comorbiditis (such as hypertension, type 2 diabetes, or dyslipidemia).
Action mechanism
Semaglutide is a GLP-1 analogue that shares 94% sequence homology with human GLP-1. Sommarutide acts as a GLP-1 receptor agonist, selectively binding to and activating the GLP-1 receptor, the target of natural GLP-1.
GLP-1 is a physiological hormone that is mediated by GLP-1 receptors and has a variety of effects on glucose.
The main mechanism leading to the long half-life of sommarutide is albumin binding, which leads to reduced renal clearance and prevents metabolic degradation. In addition, sommarutide is stable and prevents degradation of DPP-4 enzymes.
Sommarutide lowers blood sugar through mechanisms that stimulate insulin secretion and decrease glucagon secretion, both in a glucose-dependent manner. Therefore, when blood sugar is high, insulin secretion is stimulated and glucagon secretion is suppressed. The mechanism of lowering blood sugar also involves a slight delay in gastric emptying early after a meal.
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