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Nicotinamide riboside chloride 23111-00-4 NRC
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Details:
Nicotinamide Riboside Chloride（NRC）CAS 23111-00-4
Product Name: Nicotinamide riboside chloride
CAS: 23111-00-4
MF: C11H15ClN2O5
MW: 290.7
EINECS: 200-184-4
Nicotinamide riboside chloride Chemical Properties
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
solubility Soluble to 100 mM in DMSO and to 100 mM in water
form solid
color White
Uses
Nicotinamide riboside is involved in nicotinate and nicotinamide metabolism. Nicotinamide riboside was originally identified as a nutrient in milk and later discovered to be a NAD(+) precursor.
Nicotinamide riboside (NR) is a naturally occurring vitamin B-3 present in the human diet that acts as an NAD+ precursor and is suggested to improve mitochondrial function and insulin sensitivity. NR acts via activation of the NAD+-dependent sirtuin enzyme family, thereby regulating oxidative metabolism. In vitro experiments of NR supplementation have shown its successful NAD+-restoring capability and subsequent increased oxidative gene expression in skeletal muscle cells. Results from in vivo mouse models have shown improvements in insulin sensitivity and oxidative energy metabolism, including enhanced metabolic flexibility, increased aerobic exercise capacity, and indications of improved mitochondrial biogenesis.
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