4-Acetamidophenol B...

4-Acetamidophenol BP USP EP JP CP

4-Acetamidophenol BP USP EP JP CP

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1 Metric Ton

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  • Purity: 99
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Keywords

Acetamide,N-(4-hydroxyphenyl)- Acetanilide,4'-hydroxy- (7CI,8CI) 4-(Acetylamino)phenol

Quick Details

  • Appearance:White Powder
  • Application:Pharmaceutical raw material
  • PackAge:256kg/drum
  • ProductionCapacity:100000|Metric Ton|Month
  • Storage:Dry cool and clean warehouse
  • Transportation:By sea or air

Superiority:

SAFETY DATA SHEETS

According to the UN GHS revision 9

Version: 1.0

Creation Date: July 15, 2019

Revision Date: July 15, 2019

SECTION 1: Identification

1.1GHS Product identifier

Product name

Paracetamol

1.2Other means of identification

Product number

-

Other names

APAP; Panex; NAPAP

1.3Recommended use of the chemical and restrictions on use

Identified uses

Industrial and scientific research use.

Uses advised against

no data available

SECTION 2: Hazard identification

2.1Classification of the substance or mixture

Acute toxicity - Category 4, Oral

2.2GHS label elements, including precautionary statements

Pictogram(s)
Signal word

Warning

Hazard statement(s)

H302 Harmful if swallowed

Precautionary statement(s)
Prevention

P264 Wash ... thoroughly after handling.

P270 Do not eat, drink or smoke when using this product.

Response

P301+P317 IF SWALLOWED: Get medical help.

P330 Rinse mouth.

Storage

none

Disposal

P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

2.3Other hazards which do not result in classification

no data available

SECTION 3: Composition/information on ingredients

3.1Substances

Chemical name Common names and synonyms CAS number EC number Concentration
Paracetamol Paracetamol 103-90-2 203-157-5 100%

SECTION 4: First-aid measures

4.1Description of necessary first-aid measures

If inhaled

Fresh air, rest.

Following skin contact

Rinse and then wash skin with water and soap.

Following eye contact

Rinse with plenty of water (remove contact lenses if easily possible).

Following ingestion

Give one or two glasses of water to drink.

4.2Most important symptoms/effects, acute and delayed

SYMPTOMS: Symptoms of overexposure to this compound include nausea, vomiting, cyanosis from methemoglobinemia, injury to the liver, kidneys, central nervous system and heart, circulatory collapse, drowsiness, confusion, liver tenderness, low blood pressure, cardiac arrhythmias, jaundice, acute renal failure, death due to liver necrosis, metabolic acidosis, hepatic damage and cirrhosis. Other symptoms include changes in exocrine pancreas, diarrhea, irritability, somnolence, general anesthesia, fever and hepatitis. Diaphoresis and general malaise may occur. Exposure may lead to hematological reactions and, occasionally, skin rashes and other allergic reactions. The rash is usually erythematous or urticarial, but sometimes it is more serious and may be accompanied by drug fever and mucosal lesions. Exposure to large amounts may lead to pallor, anorexia, abdominal pain, abnormalities of glucose metabolism and hepatic encephalopathy. It may also lead to epigastric pain, sweating, paresthesias of distal extremities, muscular aching, weakness, dizziness, central nervous system depression (rare), pain in the upper right quadrant, enlarged liver, oliguria, anuria, coagulation defects and myocardiopathy characterized by ST segment abnormalities, T-wave flattening and pericarditis. This compound can cause purpura, generalized bleeding and hypoglycemia. It can also cause neutropenia, pancytopenia, leukopenia, thrombocytopenia and nephrotoxicity. Other symptoms may include wheezing, general discomfort, blood changes including many anemias (aplastic anemia), central nervous system stimulation, swollen tongue, rapid pulse, skin eruptions, chills, excitement, delirium, vascular collapse and convulsions. Irritation of the skin, eyes, mucous membranes and upper respiratory tract may occur. ACUTE/CHRONIC HAZARDS: This compound may be harmful by ingestion and inhalation. It may cause irritation of the skin, eyes, mucous membranes and upper respiratory tract. When heated to decomposition it emits toxic fumes of carbon monoxide, carbon dioxide and nitrogen oxides. (NTP, 1992)

4.3Indication of immediate medical attention and special treatment needed, if necessary

Emergency and supportive measures. Spontaneous vomiting may delay the oral administration of antidote or charcoal and can be treated with metoclopramide or a serotonin receptor antagonist such as ondansetron. Provide general supportive care for hepatic or renal failure if it occurs. Emergency liver transplant may be necessary for fulminant hepatic failure. Encephalopathy, metabolic acidosis, hypoglycemia, and a progressive rise in the prothrombin time are indications of severe liver injury.

SECTION 5: Fire-fighting measures

5.1Suitable extinguishing media

Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Special protective equipment for firefighters: Wear self contained breathing apparatus for fire fighting if necessary.

5.2Specific hazards arising from the chemical

Flash point data for this chemical are not available; however, it is probably combustible. (NTP, 1992)

5.3Special protective actions for fire-fighters

Use powder, alcohol-resistant foam, water spray, carbon dioxide.

SECTION 6: Accidental release measures

6.1Personal precautions, protective equipment and emergency procedures

Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Do NOT let this chemical enter the environment.

6.2Environmental precautions

Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Do NOT let this chemical enter the environment.

6.3Methods and materials for containment and cleaning up

Personal precautions: Use personal protective equipment. Avoid dust formation. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Methods and materials for containment and cleaning up: Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed containers for disposal.

SECTION 7: Handling and storage

7.1Precautions for safe handling

NO open flames. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

7.2Conditions for safe storage, including any incompatibilities

Provision to contain effluent from fire extinguishing. Store in an area without drain or sewer access.Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.

SECTION 8: Exposure controls/personal protection

8.1Control parameters

Occupational Exposure limit values

Component Paracetamol
CAS No. 103-90-2
  Limit value - Eight hours Limit value - Short term
  ppm mg/m3 ppm mg/m3
Ireland   10    
United Kingdom   10    
  Remarks

 

Biological limit values

no data available

8.2Appropriate engineering controls

Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.

8.3Individual protection measures, such as personal protective equipment (PPE)

Eye/face protection

Wear safety goggles.

Skin protection

Protective gloves.

Respiratory protection

Use local exhaust or breathing protection.

Thermal hazards

no data available

SECTION 9: Physical and chemical properties and safety characteristics

Physical state

Solid. Crystalline.

Colour

Colourless.

Odour

Odorless

Melting point/freezing point

165.5 °C. Atm. press.:966 hPa. Remarks:Other details not available.

Boiling point or initial boiling point and boiling range

273 °C. Atm. press.:966 hPa. Remarks:Other details not available.

Flammability

Combustible.

Lower and upper explosion limit/flammability limit

no data available

Flash point

177 °C. Atm. press.:966 hPa.

Auto-ignition temperature

Atm. press.:966 hPa. Remarks:Paracetamol did not catch fire on being exposed to air at room temperature of 26 degC.

Decomposition temperature

no data available

pH

4.23. Remarks:Relatively acidic.

Kinematic viscosity

no data available

Solubility

>22.7 [ug/mL]

Partition coefficient n-octanol/water

log Pow = 0.46. Temperature:25 °C. Remarks:PH not available.

Vapour pressure

0.008 Pa. Temperature:25 °C.

Density and/or relative density

0.679 g/cm³. Temperature:26 °C.

Relative vapour density

(air = 1): 5.2

Particle characteristics

no data available

SECTION 10: Stability and reactivity

10.1Reactivity

Slightly soluble in water.

10.2Chemical stability

Stable under recommended storage conditions.

10.3Possibility of hazardous reactions

Not flammable or combustible.4-HYDROXYACETANILIDE is sensitive to light. Incompatible with strong oxidizers. (NTP, 1992).

10.4Conditions to avoid

no data available

10.5Incompatible materials

Oxidizing agents

10.6Hazardous decomposition products

Hazardous decomposition products formed under fire conditions. - Carbon oxides, nitrogen oxides (NOx).

SECTION 11: Toxicological information

Acute toxicity

  • Oral: LD50 - mouse (female) - 338 mg/kg bw.
  • Inhalation: LC50 - mouse - 33 900 mg/m³ air.
  • Dermal: no data available

Skin corrosion/irritation

no data available

Serious eye damage/irritation

no data available

Respiratory or skin sensitization

no data available

Germ cell mutagenicity

no data available

Carcinogenicity

Evaluation: There is inadequate evidence in humans for the carcinogenicity of paracetamol. There is inadequate evidence in experimental animals for the carcinogenicity of paracetamol. Overall evaluation: Paracetamol is not classifiable as to its carcinogenicity to humans (Group 3).

Reproductive toxicity

no data available

STOT-single exposure

no data available

STOT-repeated exposure

Ingestion may cause effects on the kidneys and liver. This may result in impaired functions.

Aspiration hazard

A nuisance-causing concentration of airborne particles can be reached quickly.

SECTION 12: Ecological information

12.1Toxicity

  • Toxicity to fish: LC50 - Pimephales promelas - 814 mg/L - 96 h.
  • Toxicity to daphnia and other aquatic invertebrates: EC50 - Daphnia pulex - 136 mg/L - 24 h.
  • Toxicity to algae: EC50 - Pseudokirchneriella subcapitata (previous names: Raphidocelis subcapitata, Selenastrum capricornutum) - 134 mg/L - 72 h.
  • Toxicity to microorganisms: IGC50 - Tetrahymena pyriformis - 999 mg/L - 48 h.

12.2Persistence and degradability

AEROBIC: Acetaminophen has been categorized as readily biodegradable following acclimation(1). A half-life of 20 days has been reported for acetaminophen using an activated sludge inoculum(2). Half-lives of 40 and 17 days were observed when using activated sludge inoculums acclimated to phenol(3) and cresol(4), respectively. Acetaminophen reached 94% of its theoretical BOD in 6 days using an activated sludge inoculum and the Zahn-Wellens test(5). The rate constants for non-adapted, phenol-adapted, and cresol-adapted activated sludge (sludge concentrations of 500, 10, and 50 mg/L) were 0.141X10-2, 0.713X10-3, and 0.215X10-2 1/hr, respectively(6); half-lives are 21, 40, and 13 days, respectively(SRC). Acetaminophen, present at 100 ug/L, exhibited biodegradation rates of 0.014/hr and 0.00051/hr in 5 days using Tamlya and Tsumeta River water (Japan), respectively, and the OECD 301-A river die-away test. The corresponding half-lives are 50 and 1400 hours, respectively(7).

12.3Bioaccumulative potential

An estimated BCF of 3 was calculated in fish for acetaminophen(SRC), using a log Kow of 0.46(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

12.4Mobility in soil

The Koc of acetaminophen is estimated as 21(SRC), using a log Kow of 0.46(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that acetaminophen is expected to have very high mobility in soil. The pKa of acetaminophen is 9.38(4), indicating that this compound will exist partially in the anion form in the environment and anions generally adsorb less strongly to soils containing organic carbon and clay than their neutral counterparts(5). However, low mobilty was observed in soils with a high organic content. Kd values of 46 and 36 in clayey silt and silty sand, respectively, have been reported when the test compound was applied in standard dilution(6). Kd values of 45 and 41 in clayey silt and silty sand, respectively, have been reported when acetaminophen was applied as a test sludge; the average Kd value of 42 indicated low mobility(6). Acetaminophen, present at <0.009 ug/L, was not detected in leachate water (treated effluent from a muncipal wastewater treatment facility) following a 23-day soil column leaching experiment using Mohall-Laveen sandy loam (detection limit = 0.009 ug/L)(7).

12.5Other adverse effects

no data available

SECTION 13: Disposal considerations

13.1Disposal methods

Product

The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Contaminated packaging

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

SECTION 14: Transport information

14.1UN Number

ADR/RID: Not dangerous goods. (For reference only, please check.) IMDG: Not dangerous goods. (For reference only, please check.) IATA: Not dangerous goods. (For reference only, please check.)

14.2UN Proper Shipping Name

ADR/RID: Not dangerous goods. (For reference only, please check.) IMDG: Not dangerous goods. (For reference only, please check.) IATA: Not dangerous goods. (For reference only, please check.)

14.3Transport hazard class(es)

ADR/RID: Not dangerous goods. (For reference only, please check.) IMDG: Not dangerous goods. (For reference only, please check.) IATA: Not dangerous goods. (For reference only, please check.)

14.4Packing group, if applicable

ADR/RID: Not dangerous goods. (For reference only, please check.) IMDG: Not dangerous goods. (For reference only, please check.) IATA: Not dangerous goods. (For reference only, please check.)

14.5Environmental hazards

ADR/RID: Yes IMDG: Yes IATA: Yes

14.6Special precautions for user

no data available

14.7Transport in bulk according to IMO instruments

no data available

SECTION 15: Regulatory information

15.1Safety, health and environmental regulations specific for the product in question

Chemical name Common names and synonyms CAS number EC number
Paracetamol Paracetamol 103-90-2 203-157-5
European Inventory of Existing Commercial Chemical Substances (EINECS) Listed.
EC Inventory Listed.
United States Toxic Substances Control Act (TSCA) Inventory Listed.
China Catalog of Hazardous chemicals 2015 Not Listed.
New Zealand Inventory of Chemicals (NZIoC) Listed.
Philippines Inventory of Chemicals and Chemical Substances (PICCS) Listed.
Vietnam National Chemical Inventory Listed.
Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) Listed.
Korea Existing Chemicals List (KECL) Listed.

SECTION 16: Other information

Information on revision

Creation Date July 15, 2019
Revision Date July 15, 2019

Abbreviations and acronyms

  • CAS: Chemical Abstracts Service
  • ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
  • RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
  • IMDG: International Maritime Dangerous Goods
  • IATA: International Air Transportation Association
  • TWA: Time Weighted Average
  • STEL: Short term exposure limit
  • LC50: Lethal Concentration 50%
  • LD50: Lethal Dose 50%
  • EC50: Effective Concentration 50%

 

Package&Shipping

Details:

Qingdao Bravery International Trading Co., LTD. is located in the beautiful tourist city of Qingdao, is a comprehensive chemical enterprise which doing import and export business. Product range including, API, pharmacy intermediates,food additive,Surfactant ,fungicides and other general chemicals. etc.

With the developing world market, we adhere to the principle of "quality, service, integrity and development" ,Forge ahead,and constantly in pursuit of higher level of product quality and service.

We warmly welcome customers home and abroad to build mutual trust, mutual benefit and stable cooperation relation.

 

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All we want is win-win business. Send your inquiries, you will get it!

 

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