Details:

Our advantage:

1. High quality with competitive price:

1) Standard:BP/USP/EP/Enterprise standard

2) All Purity≥99%

3) We are manufacturer and can provide high quality products with factory price.

 2, Fast and safe delivery

1) Parcel can be sent out in 24 hours after payment.Tracking number available

2) Secure and discreet shipment.Various transportation methods for your choice.

3) Customs pass rate ≥99%

4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe,

and we have stock in there for transferring.

Molecular Formula	C23H32O3
Molar Mass	356.51
Density	1.1024 (rough estimate)
Melting Point	144°C
Boling Point	438.83°C (rough estimate)
Flash Point	191.1°C
Solubility	Soluble in ethanol, chloroform, methanol, water (3.6 mg/L at 27 °C), and DMSO (71 mg/m
Vapor Presure	4.47E-10mmHg at 25°C
Appearance	neat
Merck	13,3738
BRN	2480357
pKa	10.25±0.60(Predicted)
Storage Condition	Sealed in dry,Room Temperature
Refractive Index	1.4700 (estimate)
MDL	MFCD00056541
Physical and Chemical Properties	Melting Point: 144°C
Use	For the treatment of amenorrhea, menopausal syndrome, reduce milk secretion, prostate cancer, etc
In vitro study	Enhanced phosphorylation on Ser225 in MCF-7 cells suggests that Estradiol (10 nM) rapidly activates the sphingosine kinase isoenzyme sphk1. Estradiol (20 nM) stimulates the rapid release of Sphingosine-1-phosphate (S1P) and dihydro-S1p from MCF-7 cells. SphK1 and estrogen receptors are the main causes of S1P and dihydro-s1p formation. Down-regulation of ABCC1 or ABCG2 with siRNAs or pharmacological inhibitors reduced Estradiol (10 nM)-mediated S1P and dihydro-s1p release from MCF-7 cells. Estradiol (10 nM) inhibits estrogen receptor α-mediated miR-21 expression in MCF-7 human breast cancer cells. Estradiol(10 nM) activates receptor activity of several miR-21 target genes in MCF-7 cells by inhibiting miR-21 expression. Estradiol (10 nM) increased the expression of endogenous miR-21 target genes in MCF-7 cells at the protein level, but did not affect the expression of RNA levels.
In vivo study	In ovariectomized C57BL/6J mice, Estradiol (80 μg/kg/day, S. C.) significantly reduced the absolute number of total peritoneal cells and macrophages, it is characterized by double F4/80-and CD11b-positive staining. In ovariectomized C57BL/6J mice, Estradiol (80 μg/kg/day, S. C.) inhibits PI3K activity, enhancement of LPS-induced TGC-primed pro-inflammatory cytokine expression in macrophages. The proinflammatory effect of Estradiol was abrogated by down-regulation of thioglycolate-induced estrogen receptor alpha activity in macrophages.

 

Product Packaging：

1) 1kg/bag (1kg net weight, 1.1kg gross weight, packed in an aluminum foil bag)

2) 25kg/drum (25kg net weight, 28kg gross weight; Packed in a cardboard-drum with two plastic-bags inside; Drum Size: 510mm high, 360mm diameter)

 Storage：

Stored in a cool and dry well-closed container. Keep away from moisture and strong light/heat.

Delivery：

Usually within3-5 working days after full payment.

transport：

EMS,DHL, TNT, UPS ,FEDEX, BY AIR, BY SEA

DHL Express, FedEx and EMS for quantity less than 50KG, usually called as DDU service; 

Sea shipping for quantity over 500KG; And air shipping is available for 50KG above;

For high value products, please select air shipping and DHL express for safe;

Our Service:
1. Fast Delivery: We can delivery within 24 hours upon receipt of your payment.
2. Quality can be promised. Hot sell to Worldwide.
3. Payment Terms: T/T,, t/t
4. Free Sample available at any time.
5. Tracking your order at any time. Inform your order's further new situation at any time.
6. Package: Professional packing with professional materials.

 

Packing:  
  1. Inner double plastic bags----25kg/Fiber drum (35*35*45cm, GW: 28kg, NW: 25kg); 

  2. Inner double plastic bags----5kg/Aluminum foil bag (GW: 6.5kg, NW: 5kg). 

  3. Inner double plastic bags----1kg/Aluminum foil bag (GW: 1.5kg, NW: 1kg). 

P.S.: we accept packaging customization. 

  
Delivery:   

  1. Stock products are normally shipping within 3 working days.  

  2. For rush delivery, please contact our sales team for particular arrangement. 

Shipping Details: 
  1. We ship goods via DHL, Fedex, UPS, TNT, China post, NL Post and other couriers, weight from 10g to 1000kg or even bulker. 

  2. Shipping details & shipping documents will be provided and sent by email. 

  3. We keep tracking the shippment until clients well received. 

  4. After years export shipping experience, with professional and experienced cooperated forwarders, we ensure that goods can be delivered in multiple ways safetly and efficiently. 

About us

Our company specializes in processing and selling chemical raw materials, chemical products, pharmaceutical intermediates, veterinary medicine intermediates, dye intermediates, pigments, cosmetics raw materials and chemical reagents,  

We have compalete sales and service team , information feedback vertical integration of a sound marketing network, products are sold throughout the country and exported to South Asia, Europe, America, Africa and other more than 20 countries and regions.  

Companies adhering to the "pursuit of quality, innovation and development" business philosophy, to serve as a foundation, for the survival by the quality, seek development by science and technology, adhere to quilty comes first,fair price,good sense of customer service and responsibility. in the future hebei Nengqian import and export trade Co.,Ltd will always hold "integrity, innovation" business philosophy, to achieve honesty management, on the way of specialization, internationalization,  Keep moving!  

 

FAQ: 
1. Are you a trade company or factory   
We are a  factory with our own trading company.  

2.How do you control the quality   
Our factory is equipped with professional technicians to control quality, out inspectors take sample for testing every 2 hours to ensure the quality of our production. We also accept BV, SGS or any other Third-party inspection.   

3. How long is lead time   
We deliver goods within 3 days for small order, 7-10 days for bulk order.   

4. Where is your factory located  How can I visit the factory   
 Our factory located in HEBEI, China.

5. Can i get some samples  
  Yes, we can supply free sample, but the shipping cost be paid by our customers. 

6. How to start orders or make payments  
  Proforma invoice will be sent first after confirmation of order, enclosed our bank information.Payment by T/T,  

7. How to confirm the Product Quality before placing orders  
  You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. 
  You can send us your product specifications and requests,we will manufacture the products according to your requests. 

8. How long is lead time

We deliver goods within 3 days for small order, 7-10 days for bulk order.

 

9. How do you treat quality complaint

  First of all, our quality control will reduce the quality problem to near zero. If there is a realquality problem caused by us, we will send you free goods for replacement or refund your loss.