IDRA-21 22503-72-6 Pharmaceutical raw material
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IDRA-21 CAS 22503-72-6
name:IDRA 21
CAS :22503-72-6
Molecular formula:C8H9ClN2O2S
molecular weight:232.69
EINECS:1592732-453-0
Melting point 209°C(Solv:aceticacid(64-19-7))
The boiling point 405.1±55.0°C(Predicted)
The density 1.394±0.06g/cm3(Predicted)
Storage conditions KChemicalbookeepindarkplace,Inertatmosphere,Roomtemperature
solubility DMSO(Slightly),Methanol(Slightly,Sonicated)
A crystalline solid
IDRA 21 Chemical Properties
Melting point 209 °C(Solv: acetic acid (64-19-7))
Boiling point 405.1±55.0 °C(Predicted)
density 1.394±0.06 g/cm3(Predicted)
storage temp. Keep in dark place,Inert atmosphere,Room temperature
solubility DMSO (Slightly), Methanol (Slightly, Sonicated)
form Solid
pka 9.78±0.40(Predicted)
color Off-White to Pale Yellow
InChIKey VZRNTCHTJRLTMU-UHFFFAOYSA-N
Uses IDRA-21 inhibits AMPA receptor desensitization and enhances cognition by a related mechanism. IDRA-21 is more able to cross the blood-brain barrier than Cyclothiazide (C988960).
Uses IDRA-21 is a benzothiadiazine derivative and a positive allosteric modulator of glutamate AMPA receptors (1,2,3,4). It is able to increase excitatory synaptic strength by inhibiting AMPA receptor desensitization. IDRA 21 may exhibit therapeutic effects to ameliorate memory deficits in patients with cognitive impairments such as Alzheimer''s disease.
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