Bleomycin sulfate [Bleomycins] Bleomycine [INN-French] Bleomycin, sulfate
According to the UN GHS revision 10
Version: 1.0
Creation Date: July 15, 2019
Revision Date: July 15, 2019
Product name |
Bleomycin, sulfate (salt) |
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Product number |
- |
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Other names |
Blenmycins;Blocamicina;BLEO |
Identified uses |
Industrial and scientific research use. |
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Uses advised against |
no data available |
Germ cell mutagenicity, Category 1B
Carcinogenicity, Category 2
Reproductive toxicity, Category 2
Pictogram(s) | |
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Signal word |
Danger |
Hazard statement(s) |
H340 May cause genetic defects H351 Suspected of causing cancer H361 Suspected of damaging fertility or the unborn child |
Precautionary statement(s) | |
Prevention |
P203 Obtain, read and follow all safety instructions before use. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... |
Response |
P318 IF exposed or concerned, get medical advice. |
Storage |
P405 Store locked up. |
Disposal |
P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal. |
no data available
Chemical name | Common names and synonyms | CAS number | EC number | Concentration |
---|---|---|---|---|
Bleomycin, sulfate (salt) | Bleomycin, sulfate (salt) | 9041-93-4 | 232-925-2 | 100% |
If inhaled
Move the victim into fresh air. If breathing is difficult, give oxygen. If not breathing, give artificial respiration and consult a doctor immediately. Do not use mouth to mouth resuscitation if the victim ingested or inhaled the chemical.
Following skin contact
Take off contaminated clothing immediately. Wash off with soap and plenty of water. Consult a doctor.
Following eye contact
Rinse with pure water for at least 15 minutes. Consult a doctor.
Following ingestion
Rinse mouth with water. Do not induce vomiting. Never give anything by mouth to an unconscious person. Call a doctor or Poison Control Center immediately.
SYMPTOMS: Symptoms of exposure to this compound may include mucocutaneous reactions such as mouth ulcerations; skin redness, ulceration and blistering; headache, mental confusion, fever, chills, cough, wheezing, pneumonitis, nausea, vomiting, abdominal pain, hypotension, cardiorespiratory collapse, hair loss, and pulmonary fibrosis. ACUTE/CHRONIC HAZARDS: Toxic: primarily in the skin and lungs. (NTP, 1992)
Maintain an open airway and assist ventilation if necessary. Treat coma, seizures, hypotension, and arrhythmias if they occur. Treat nausea and vomiting with metoclopramide and fluid loss caused by gastroenteritis with intravenous crystalloid fluids. Bone marrow depression should be treated with the assistance of an experienced hematologist or oncologist. Extravasation; immediately stop the infusion and withdraw as much fluid as possible by negative pressure on the syringe. ... Very few specific treatments or antidotes are available. Administer activated charcoal orally if conditions are appropriate. Gastric lavage is not necessary after small to moderate ingestions if activated charcoal can be given promptly. Because of the rapid intracellular incorporation of most of these agents, dialysis and other extracorporeal removal procedures are generally not effective. Antineoplastic agents
Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)
Flash point data for this compound are not available. It is probably nonflammable. (NTP, 1992)
Wear self-contained breathing apparatus for firefighting if necessary.
Avoid dust formation. Avoid breathing mist, gas or vapours.Avoid contacting with skin and eye. Use personal protective equipment.Wear chemical impermeable gloves. Ensure adequate ventilation.Remove all sources of ignition. Evacuate personnel to safe areas.Keep people away from and upwind of spill/leak.
Prevent further spillage or leakage if it is safe to do so. Do not let the chemical enter drains. Discharge into the environment must be avoided.
PRECAUTIONS FOR ANTINEOPLASTIC AGENTS:/ Spill kits containing all materials needed to clean up spills of hazardous drugs should be assembled or purchased. These kits should be readily available in all areas where hazardous drugs are routinely handled. If hazardous drugs are being prepared or administered in a nonroutine area (home setting or unusual patient-care area), a spill kit should be obtained by the drug handler. The kit should include two pairs of disposable gloves (one outer pair of utility gloves and one inner latex pair); low-permeability, disposable protective garments (coveralls or gown and shoe covers); safety glasses or splash goggles; respirator; absorbent, plastic-backed sheets or spill pads; disposable toweling; at least 2 sealable thick plastic hazardous waste disposal bags (prelabeled with an appropriate warning label); a disposable scoop for collecting glass fragments; and a puncture-resistant container for glass fragments. All individuals who routinely handle hazardous drugs must be trained in proper spill management and cleanup procedures. Spills and breakages must be cleaned up immediately according to the following procedures. If the spill is not located in a confined space, the spill area should be identified and other people should be prevented from approaching and spreading the contamination. Wearing protective apparel from the spill kit, workers should remove any broken glass fragments and place them in the puncture-resistant container. Liquids should be absorbed with a spill pad; powder should be removed with damp disposable gauze pads or soft toweling. The hazardous material should be completely removed and the area rinsed with water and then cleaned with detergent. The spill cleanup should proceed progressively from areas of lesser to greater contamination. The detergent should be thoroughly rinsed and removed. All contaminated materials should be placed in the disposal bags provided and sealed and transported to a designated containment receptacle. Spills occurring in the biohazard cabinet should be cleaned up immediately; a spill kit should be used if the volume exceeds 150 ml or the contents of one drug vial or ampule. If there is broken glass, utility gloves should be worn to remove it and place it in the puncture-resistant container located in the biohazard cabinet. The biological safety cabinet, including the drain spillage trough, should be thoroughly cleaned. If the spill is not easily and thoroughly contained, the biological safety cabinet should be decontaminated after cleanup. If the spill contaminates the high efficiency particulate air filter, use of the biological safety cabinet should be suspended until the cabinet has been decontaminated and the high efficiency particulate air filter replaced. Antineoplastic agents
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
Occupational Exposure limit values
no data available
Biological limit values
no data available
Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.
Eye/face protection
Wear tightly fitting safety goggles with side-shields conforming to EN 166(EU) or NIOSH (US).
Skin protection
Wear fire/flame resistant and impervious clothing. Handle with gloves. Gloves must be inspected prior to use. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.
Respiratory protection
If the exposure limits are exceeded, irritation or other symptoms are experienced, use a full-face respirator.
Thermal hazards
no data available
Physical state |
PHYSICAL DESCRIPTION: Colorless or yellowish powder. Possible bluish color depending on copper content. (NTP, 1992) |
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Colour |
Colorless to yellow powder |
Odour |
no data available |
Melting point/freezing point |
-1°C(lit.) |
Boiling point or initial boiling point and boiling range |
156°C |
Flammability |
no data available |
Lower and upper explosion limit/flammability limit |
no data available |
Flash point |
51°C(lit.) |
Auto-ignition temperature |
no data available |
Decomposition temperature |
no data available |
pH |
no data available |
Kinematic viscosity |
no data available |
Solubility |
Soluble (NTP, 1992) |
Partition coefficient n-octanol/water |
no data available |
Vapour pressure |
no data available |
Density and/or relative density |
no data available |
Relative vapour density |
no data available |
Particle characteristics |
no data available |
no data available
In vitro, bleomycin is inactivated by agents containing sulfhydryl groups, hydrogen peroxide, and ascorbic acid. Bleomycin sulfate sterile powder is stable under refrigeration at 2-8 deg C and should not be used after the expiration date is reached.
no data available
no data available
no data available
no data available
Acute toxicity
Skin corrosion/irritation
no data available
Serious eye damage/irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
Evaluation: There is limited evidence in humans for the carcinogenicity of etoposide. There is sufficient evidence in humans for the carcinogenicity of etoposide given in combination with cisplatin and bleomycin. There is inadequate evidence in experimental animals for the carcinogenicity of etoposide. Overall evaluation: Etoposide is probably carcinogenic to humans (Group 2A). In reaching this evaluation, the Working Group noted that etoposide causes distinctive cytogenetic lesions in leukemic cells that can be readily distinguished from those induced by alkylating agents. The short latency of these leukemias contrasts with that of leukemia induced by alkylating agents. Potent protein masked DNA breakage and clastogenic effects occur in human cells in vitro and animal cells in vivo. Etoposide in combination with cisplatin or bleomycin is carcinogenic to humans. Etoposide in combination with cisplatin or bleomycin
Reproductive toxicity
no data available
STOT-single exposure
no data available
STOT-repeated exposure
no data available
Aspiration hazard
no data available
no data available
no data available
no data available
no data available
Product
The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Contaminated packaging
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
ADR/RID: UN2514 (For reference only, please check.) | IMDG: UN2514 (For reference only, please check.) | IATA: UN2514 (For reference only, please check.) |
ADR/RID: BROMOBENZENE (For reference only, please check.) | IMDG: BROMOBENZENE (For reference only, please check.) | IATA: BROMOBENZENE (For reference only, please check.) |
ADR/RID: 3 (For reference only, please check.) | IMDG: 3 (For reference only, please check.) | IATA: 3 (For reference only, please check.) |
ADR/RID: III (For reference only, please check.) | IMDG: III (For reference only, please check.) | IATA: III (For reference only, please check.) |
ADR/RID: No | IMDG: No | IATA: No |
no data available
no data available
Chemical name | Common names and synonyms | CAS number | EC number |
---|---|---|---|
Bleomycin, sulfate (salt) | Bleomycin, sulfate (salt) | 9041-93-4 | 232-925-2 |
European Inventory of Existing Commercial Chemical Substances (EINECS) | Listed. | ||
EC Inventory | Listed. | ||
United States Toxic Substances Control Act (TSCA) Inventory | Not Listed. | ||
China Catalog of Hazardous chemicals 2015 | Not Listed. | ||
New Zealand Inventory of Chemicals (NZIoC) | Not Listed. | ||
Philippines Inventory of Chemicals and Chemical Substances (PICCS) | Not Listed. | ||
Vietnam National Chemical Inventory | Not Listed. | ||
Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) | Not Listed. | ||
Korea Existing Chemicals List (KECL) | Not Listed. |
Information on revision
Creation Date | July 15, 2019 |
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Revision Date | July 15, 2019 |
Package&Shipping
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