β-Nicotinamide Mononucleotide NMN

Details:

Beta-Nicotinamide Mononucleotide（NMN）cas 1094-61-7

Product Name: β-Nicotinamide Mononucleotide

CAS: 1094-61-7

MF: C11H15N2O8P

MW: 334.22

EINECS: 214-136-5

β-Nicotinamide Mononucleotide Chemical Properties

Melting point 166 °C(dec.)

storage temp. -20°C

solubility DMSO (Slightly, Heated), Methanol (Slightly), Water (Slightly)

form Solid

color White to Yellow

Merck 13,6697

BRN 3570187

Stability: Very Hygroscopic

β-Nicotinamide mononucleotide (NMN) is used to study binding motifs within RNA aptamers and ribozyme activation processes involving β-nicotinamide mononucleotide (β-NMN)-activated RNA fragments. NMN is a nucleotide derived from ribose and nicotinamide. Niacinamide (nicotinamide,) is a derivative of vitamin B3, also known as niacin.) As a biochemical precursor of NAD+, it may be useful in the prevention of pellagra.

β-Nicotinamide mononucleotide is an intermediate in the biosynthesis of nicotinamide adenine dinucleotide (NAD+). Nicotinamide phosphoribosyltransferase (Nampt) catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to generate β-NMN, which is subsequently converted to NAD+ by β-NMN adenyltransferase.At 50-100 μM, β-NMN has been used to enhance NAD biosynthesis and glucose-stimulated insulin secretion in a Nampt+/- mouse model of metabolic disease, demonstrating a role for Nampt in β cell function.Furthermore, at 500 mg/kg/day, it has been shown to ameliorate glucose intolerance in high-fat diet-induced type 2 diabetes mice by restoring NAD+ levels.