(S)-3-Hydroxy-gamma-butyrolactone 7331-52-4 (3S)-Hydroxy-g-butyrolactone
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Product Name: (S)-3-Hydroxy-gamma-butyrolactone
CAS: 7331-52-4
MF: C4H6O3
MW: 102.09
EINECS: 434-990-4
Boiling point 98-100 °C0.3 mm Hg(lit.)
density 1.241 g/mL at 25 °C(lit.)
refractive index n20/D 1.464(lit.)
Fp >230 °F
storage temp. Inert atmosphere,2-8°C
Description (S)-3-Hydroxy-gamma-butyrolactone is an important intermediate in organic synthesis and an important chiral pool. It is mainly used in the synthesis of some natural products and some bioactive chiral drugs or antibiotic chiral drugs. For example, it is a key intermediate in synthesis of nerve regulator (R)-GABOB and brain metabolic accelerant S-oxiracetam (S-ORC). It can be deoxidized to (S)-(+)-3-Hydroxytetrahydrofuran which is an important intermediate of anti-AIDS drugs. It is also used in the synthesis of S(-)-3-hydroxy-4-bromobutyric acid which is a potential stabilizer.
Chemical Properties Colorless to light yellow liquid.
Uses (S)-3-Hydroxy-γ-butyrolactone can be used as an anticancer drug resistance inhibitor.
Precautions For best results, Store in cool, dry place in tightly closed containers, under inert gas and protected from moisture as this substance is moisture sensitive. (S)-3-Hydroxy-gamma-butyrolactone is incompatible with oxidizing agents. This chemical causes skin irritation and serious eye irritation.
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