Superiority:

Chemical Safety Data Sheet MSDS / SDS

L-Histidine

Revision Date:2024-08-24Revision Number:1

SECTION 1: Identification of the substance/mixture and of the company/undertaking

Product identifier

• Product name: L-Histidine
• CBnumber: CB6705020
• CAS: 71-00-1
• EINECS Number: 200-745-3
• Synonyms: L-HISTIDINE,Histidine

Relevant identified uses of the substance or mixture and uses advised against

• Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
• Uses advised against: none

SECTION 2: Hazards identification

GHS Label elements, including precautionary statements

• Signal wordNo signal word

Hazard statement(s)

none

Prevention

none

Response

none

Storage

none

Disposal

none

SECTION 3: Composition/information on ingredients

Substance

• Product name: L-Histidine
• Synonyms: L-HISTIDINE,Histidine
• CAS: 71-00-1
• EC number: 200-745-3
• MF: C6H9N3O2
• MW: 155.15

SECTION 4: First aid measures

Description of first aid measures

If inhaled

After inhalation: fresh air.

In case of skin contact

In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/ shower.

In case of eye contact

After eye contact: rinse out with plenty of water. Remove contact lenses.

If swallowed

After swallowing: make victim drink water (two glasses at most). Consult doctor if feeling unwell.

Most important symptoms and effects, both acute and delayed

The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11

Indication of any immediate medical attention and special treatment needed

No data available

SECTION 5: Firefighting measures

Extinguishing media

Suitable extinguishing media

Water Foam Carbon dioxide (CO2) Dry powder

Unsuitable extinguishing media

For this substance/mixture no limitations of extinguishing agents are given.

Special hazards arising from the substance or mixture

Carbon oxides, Nitrogen oxides (NOx) Combustible.

Development of hazardous combustion gases or vapours possible in the event of fire.

Advice for firefighters

In the event of fire, wear self-contained breathing apparatus.

Further information

Suppress (knock down) gases/vapors/mists with a water spray jet. Prevent fire extinguishing water from contaminating surface water or the ground water system.

NFPA 704

1

0

0

	HEALTH	1	Exposure would cause irritation with only minor residual injury (e.g. acetone, sodium bromate, potassium chloride)
	FIRE	0	Materials that will not burn under typical fire conditions, including intrinsically noncombustible materials such as concrete, stone, and sand. Materials that will not burn in air when exposed to a temperature of 820 °C (1,500 °F) for a period of 5 minutes.(e.g. Carbon tetrachloride)
	REACT	0	Normally stable, even under fire exposure conditions, and is not reactive with water (e.g. helium,N2)
	SPEC. HAZ.

SECTION 6: Accidental release measures

Personal precautions, protective equipment and emergency procedures

Advice for non-emergency personnel: Avoid inhalation of dusts. Evacuate the danger area, observe emergency procedures, consult an expert.

For personal protection see section 8.

Environmental precautions

Do not let product enter drains.

Methods and materials for containment and cleaning up

Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see sections 7 and 10). Take up dry. Dispose of properly. Clean up affected area. Avoid generation of dusts.

Reference to other sections

For disposal see section 13.

SECTION 7: Handling and storage

Precautions for safe handling

For precautions see section 2.2.

Conditions for safe storage, including any incompatibilities

Tightly closed. Dry.

Specific end use(s)

Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

SECTION 8: Exposure controls/personal protection

control parameter

Hazard composition and occupational exposure limits

Does not contain substances with occupational exposure limits.

Exposure controls

Appropriate engineering controls

Change contaminated clothing. Wash hands after working with substance.

Personal protective equipment

Eye/face protection

Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Safety glasses

Skin protection

Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.

The selected protective gloves have to satisfy the specifications of Regulation (EU) 2016/425 and the standard EN 374 derived from it.

Full contact

Material: Nitrile rubber

Minimum layer thickness: 0,11 mm Break through time: 480 min

Material tested:Dermatril? (KCL 740 / Aldrich Z677272, Size M)

Splash contact Material: Nitrile rubber

Minimum layer thickness: 0,11 mm Break through time: 480 min

Material tested:Dermatril? (KCL 740 / Aldrich Z677272, Size M)

data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, e-mail sales@kcl.de, test method: EN374

If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the EC approved gloves. This recommendation is advisory only and must be evaluated by an industrial hygienist and safety officer familiar with the specific situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario.

 

Respiratory protection

required when dusts are generated.

Our recommendations on filtering respiratory protection are based on the following standards: DIN EN 143, DIN 14387 and other accompanying standards relating to the used respiratory protection system.

 

Control of environmental exposure

Do not let product enter drains.

SECTION 9: Physical and chemical properties

Information on basic physicochemical properties

• Appearancewhite solid
• Odourweak
• Odour ThresholdNo data available
• pHca.7,7 at 10 g/l at 20 °C
• Melting point/freezing pointMelting point/range: 282 °C
• Initial boiling point and boiling range278.95°C (rough estimate)
• Flash pointNo data available
• Evaporation rateNo data available
• Flammability (solid, gas)No data available
• Upper/lower flammability or explosive limitsNo data available
• Vapour pressureNo data available
• Vapour densityNo data available
• Relative densityNo data available
• Water solubility38,2 g/l at 20 °C
• Partition coefficient: n-octanol/waterlog Pow: -3,32 - Bioaccumulation is not expected., (Lit.)
• Autoignition temperatureNo data available
• Decomposition temperature287 °C -
• ViscosityNo data available
• Explosive propertiesNo data available
• Oxidizing propertiesNo data available
• λmaxλ: 260 nm Amax: 0.05
  λ: 280 nm Amax: 0.05

Other safety information

No data available

SECTION 10: Stability and reactivity

Reactivity

The following applies in general to flammable organic substances and mixtures: in correspondingly fine distribution, when whirled up a dust explosion potential may generally be assumed.

Chemical stability

The product is chemically stable under standard ambient conditions (room temperature) .

Possibility of hazardous reactions

No data available

Conditions to avoid

no information available

Incompatible materials

No data available

Hazardous decomposition products

Hazardous decomposition products formed under fire conditions. - Carbon oxides, Nitrogen oxides (NOx)

Other decomposition products - No data available In the event of fire: see section 5

SECTION 11: Toxicological information

Information on toxicological effects

Acute toxicity

LD50 Oral - Rat - male and female - > 5.110 mg/kg (OECD Test Guideline 423)

Skin corrosion/irritationSerious eye damage/eye irritation

Eyes - In vitro study Result: No eye irritation (OECD Test Guideline 437)

Respiratory or skin sensitization

No data available

Germ cell mutagenicity

No data available

Carcinogenicity

IARC: No ingredient of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.

Reproductive toxicity

No data available

Specific target organ toxicity - single exposure

No data available

Specific target organ toxicity - repeated exposure

No data available

Aspiration hazard

No data available

Additional Information

RTECS: MS3070000
To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.

Toxicity

LD50 orally in Rabbit: > 5110 mg/kg

SECTION 12: Ecological information

Toxicity

 

Toxicity to daphnia and other aquatic invertebrates

 

static test EC50 - Daphnia magna (Water flea) - > 100 mg/l - 48 h (OECD Test Guideline 202)

 

Toxicity to algae

static test EC10 - Desmodesmus subspicatus (green algae) - 58 mg/l

 

- 72 h

(OECD Test Guideline 201)

static test NOEC - Desmodesmus subspicatus (green algae) - 10 mg/l

- 72 h

(OECD Test Guideline 201)

static test ErC50 - Desmodesmus subspicatus (green algae) - > 100 mg/l - 72 h

(OECD Test Guideline 201)

Persistence and degradability

Bioaccumulative potential

Mobility in soil

Results of PBT and vPvB assessment

This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

Other adverse effects

Discharge into the environment must be avoided.

SECTION 13: Disposal considerations

Waste treatment methods

Product

See www.retrologistik.com for processes regarding the return of chemicals and containers, or contact us there if you have further questions.

SECTION 14: Transport information

UN number

ADR/RID: - IMDG: - IATA: -

UN proper shipping name

ADR/RID: Not dangerous goods IMDG: Not dangerous goods IATA: Not dangerous goods

Transport hazard class(es)

ADR/RID: - IMDG: - IATA: -

Packaging group

ADR/RID: - IMDG: - IATA: -

Environmental hazards

ADR/RID: no IMDG Marine pollutant: no IATA: no

Special precautions for user

Further information

Not classified as dangerous in the meaning of transport regulations.

SECTION 15: Regulatory information

Safety, health and environmental regulations/legislation specific for the substance or mixture

Regulations on the Safety Management of Hazardous Chemicals

China Catalog of Hazardous chemicals 2015:Not Listed. website: #

Measures for Environmental Management of New Chemical Substances

Chinese Chemical Inventory of Existing Chemical Substances (China IECSC):Listed. website: #

EC Inventory:Listed.

European Inventory of Existing Commercial Chemical Substances (EINECS):Listed. website: #

Korea Existing Chemicals List (KECL):Listed. website: //ncis.nier.go.kr

New Zealand Inventory of Chemicals (NZIoC):Listed. website: #

Philippines Inventory of Chemicals and Chemical Substances (PICCS):Listed. website: #

United States Toxic Substances Control Act (TSCA) Inventory:Listed. website: #

Vietnam National Chemical Inventory:Listed. website: #

SECTION 16: Other information

Abbreviations and acronyms

• ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
• CAS: Chemical Abstracts Service
• EC50: Effective Concentration 50%
• IATA: International Air Transportation Association
• IMDG: International Maritime Dangerous Goods
• LC50: Lethal Concentration 50%
• LD50: Lethal Dose 50%
• RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
• STEL: Short term exposure limit
• TWA: Time Weighted Average

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