Superiority:

Chemical Safety Data Sheet MSDS / SDS

L-Histidine hydrochloride monohydrate

Revision Date:2024-10-12Revision Number:1

SECTION 1: Identification of the substance/mixture and of the company/undertaking

Product identifier

• Product name: L-Histidine hydrochloride monohydrate
• CBnumber: CB1369616
• CAS: 5934-29-2
• EINECS Number: 611-821-4
• Synonyms: L-Histidine monohydrochloride monohydrate,L-Histidine hydrochloride monohydrate

Relevant identified uses of the substance or mixture and uses advised against

• Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
• Uses advised against: none

 

SECTION 2: Hazards identification

GHS Label elements, including precautionary statements

Pictogram(s)

• Signal wordWarning

Hazard statement(s)

H319 Causes serious eye irritation

Prevention

P264 Wash ... thoroughly after handling.

P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...

Response

P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Storage

none

Disposal

none

SECTION 3: Composition/information on ingredients

Substance

• Product name: L-Histidine hydrochloride monohydrate
• Synonyms: L-Histidine monohydrochloride monohydrate,L-Histidine hydrochloride monohydrate
• CAS: 5934-29-2
• EC number: 611-821-4
• MF: C6H12ClN3O3
• MW: 209.63

SECTION 4: First aid measures

Description of first aid measures

General advice

Show this material safety data sheet to the doctor in attendance.

If inhaled

After inhalation: fresh air.

In case of skin contact

In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/ shower.

In case of eye contact

After eye contact: rinse out with plenty of water. Call in ophthalmologist. Remove contact lenses.

If swallowed

After swallowing: immediately make victim drink water (two glasses at most). Consult a physician.

Most important symptoms and effects, both acute and delayed

The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11

Indication of any immediate medical attention and special treatment needed

No data available

SECTION 5: Firefighting measures

Extinguishing media

Suitable extinguishing media

Water Foam Carbon dioxide (CO2) Dry powder

Unsuitable extinguishing media

For this substance/mixture no limitations of extinguishing agents are given.

Special hazards arising from the substance or mixture

Carbon oxides Nitrogen oxides (NOx) Hydrogen chloride gas Combustible.

Risk of dust explosion.

Development of hazardous combustion gases or vapours possible in the event of fire.

Advice for firefighters

In the event of fire, wear self-contained breathing apparatus.

Further information

Suppress (knock down) gases/vapors/mists with a water spray jet. Prevent fire extinguishing water from contaminating surface water or the ground water system.

NFPA 704

1

0

0

	HEALTH	1	Exposure would cause irritation with only minor residual injury (e.g. acetone, sodium bromate, potassium chloride)
	FIRE	0	Materials that will not burn under typical fire conditions, including intrinsically noncombustible materials such as concrete, stone, and sand. Materials that will not burn in air when exposed to a temperature of 820 °C (1,500 °F) for a period of 5 minutes.(e.g. Carbon tetrachloride)
	REACT	0	Normally stable, even under fire exposure conditions, and is not reactive with water (e.g. helium,N2)
	SPEC. HAZ.

SECTION 6: Accidental release measures

Personal precautions, protective equipment and emergency procedures

Advice for non-emergency personnel: Avoid inhalation of dusts. Avoid substance contact. Ensure adequate ventilation. Evacuate the danger area, observe emergency procedures, consult an expert.

For personal protection see section 8.

Environmental precautions

Do not let product enter drains.

Methods and materials for containment and cleaning up

Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see sections 7 and 10). Take up dry. Dispose of properly. Clean up affected area. Avoid generation of dusts.

Reference to other sections

For disposal see section 13.

SECTION 7: Handling and storage

Precautions for safe handling

For precautions see section 2.2.

Conditions for safe storage, including any incompatibilities

Storage conditions

Tightly closed. Dry.

Specific end use(s)

Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

SECTION 8: Exposure controls/personal protection

control parameter

Hazard composition and occupational exposure limits

Does not contain substances with occupational exposure limits.

Exposure controls

Personal protective equipment

Eye/face protection

Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Safety glasses

Skin protection

This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN374 please contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell, Internet: www.kcl.de).

Full contact

Material: Nitrile rubber

Minimum layer thickness: 0,11 mm Break through time: 480 min

Material tested:KCL 741 Dermatril? L

This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN374 please contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell, Internet: www.kcl.de).

Splash contact Material: Nitrile rubber

Minimum layer thickness: 0,11 mm Break through time: 480 min

Material tested:KCL 741 Dermatril? L

Body Protection

protective clothing

Respiratory protection

required when dusts are generated.

Our recommendations on filtering respiratory protection are based on the following standards: DIN EN 143, DIN 14387 and other accompanying standards relating to the used respiratory protection system.

Recommended Filter type: Filter type P2

The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory protective devices are carried out according to the instructions of the producer.

These measures have to be properly documented.

Control of environmental exposure

Do not let product enter drains.

SECTION 9: Physical and chemical properties

Information on basic physicochemical properties

• Appearancewhite crystalline
• Odourweak characteristic odour
• Odour ThresholdNo data available d) pH 4,38 - 4,48 at 149,55 g/l at 20 °C Melting point/freezing point Initial boiling point and boiling range Melting point/range: 254 °C - dec. Decomposes below the boiling point. Flash point Not applicable Evaporation rate No data available Flammability (solid, gas) Upper/lower flammability or explosive limits No data available No data available Vapour pressure< 0,1 hPa at 20 °C - OECD Test Guideline 104 Vapour density No data available Density 1,4723 g/cm3 at 20 °C - OECD Test Guideline 109 Relative density No data available Water solubility 149,55 g/l at 20 °C - OECD Test Guideline 105 Partition coefficient: n-octanol/water Autoignition temperature Decomposition temperature No data available >268 °C at 1.013 hPa - Relative self-ignition temperature for solidsdoes not ignite >268 °C - Viscosity Viscosity, kinematic: No data available Viscosity, dynamic: No data available Explosive properties No data available Oxidizing properties No data available
• Melting point/freezing pointMelting point/range: 254 °C - dec.
• Initial boiling point and boiling rangeDecomposes below the boiling point.
• Flash pointNot applicable
• Evaporation rateNo data available
• Flammability (solid, gas)No data available
• Upper/lower flammability or explosive limitsNo data available
• Vapour pressure< 0,1 hPa at 20 °C - OECD Test Guideline 104
• Vapour density<1 hPa (20 °C)
• Relative density1,4723 g/cm3 at 20 °C - OECD Test Guideline 109 No data available
• Water solubility149,55 g/l at 20 °C - OECD Test Guideline 105
• Partition coefficient: n-octanol/waterH₂O: 100 mg/mL
• Autoignition temperature>268 °C at 1.013 hPa - Relative self-ignition temperature for solidsdoes not ignite
• Decomposition temperature>268 °C -
• ViscosityViscosity, kinematic: No data available Viscosity, dynamic: No data available
• Explosive propertiesNo data available
• Oxidizing propertiesNo data available

Other safety information

No data available

SECTION 10: Stability and reactivity

Reactivity

The following applies in general to flammable organic substances and mixtures: in correspondingly fine distribution, when whirled up a dust explosion potential may generally be assumed.

Chemical stability

The product is chemically stable under standard ambient conditions (room temperature) .

Possibility of hazardous reactions

Violent reactions possible with: Strong oxidizing agents

 

Conditions to avoid

no information available

Incompatible materials

No data available

Hazardous decomposition products

In the event of fire: see section 5

SECTION 11: Toxicological information

Information on toxicological effects

Acute toxicity

LD50 Oral - Rat - female - > 2.000 mg/kg
(OECD Test Guideline 423) Inhalation

Skin corrosion/irritation

No data available

Serious eye damage/eye irritation

Eyes - Human Result: Eye irritation
(OECD Test Guideline 492) Remarks: (ECHA)

Respiratory or skin sensitization

No data available

Germ cell mutagenicity

No data available

Carcinogenicity

No data available

Reproductive toxicity

No data available

Specific target organ toxicity - single exposure

No data available

Specific target organ toxicity - repeated exposure

No data available

Aspiration hazard

No data available

SECTION 12: Ecological information

Toxicity

No data available

Persistence and degradability

No data available

Bioaccumulative potential

No data available

Mobility in soil

No data available

Results of PBT and vPvB assessment

This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

Other adverse effects

No data available

SECTION 13: Disposal considerations

Waste treatment methods

Product

See www.retrologistik.com for processes regarding the return of chemicals and containers, or contact us there if you have further questions.

SECTION 14: Transport information

UN number

ADR/RID: - IMDG: - IATA: -

UN proper shipping name

ADR/RID: Not dangerous goods IMDG: Not dangerous goods IATA: Not dangerous goods

Transport hazard class(es)

ADR/RID: - IMDG: - IATA: -

Packaging group

ADR/RID: - IMDG: - IATA: -

Environmental hazards

ADR/RID: no IMDG Marine pollutant: no IATA: no

Special precautions for user

Further information

Not classified as dangerous in the meaning of transport regulations.

SECTION 15: Regulatory information

Safety, health and environmental regulations/legislation specific for the substance or mixture

Regulations on the Safety Management of Hazardous Chemicals

China Catalog of Hazardous chemicals 2015:Not Listed. website: #

Measures for Environmental Management of New Chemical Substances

Chinese Chemical Inventory of Existing Chemical Substances (China IECSC):Listed. website: #

New Zealand Inventory of Chemicals (NZIoC):Listed. website: #

Philippines Inventory of Chemicals and Chemical Substances (PICCS):Listed. website: #

Vietnam National Chemical Inventory:Listed. website: #

EC Inventory:Not Listed.

European Inventory of Existing Commercial Chemical Substances (EINECS):Not Listed. website: #

Korea Existing Chemicals List (KECL):Not Listed. website: //ncis.nier.go.kr

United States Toxic Substances Control Act (TSCA) Inventory:Not Listed. website: #

SECTION 16: Other information

Abbreviations and acronyms

• ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
• CAS: Chemical Abstracts Service
• EC50: Effective Concentration 50%
• IATA: International Air Transportation Association
• IMDG: International Maritime Dangerous Goods
• LC50: Lethal Concentration 50%
• LD50: Lethal Dose 50%
• RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
• STEL: Short term exposure limit
• TWA: Time Weighted Average

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