Raw Material 2-Chloro-1,3,2-dioxaphospholane-2-oxide

Details:

Product Name: 2-Chloro-1,3,2-dioxaphospholane-2-oxide

CAS: 6609-64-9

MF: C2H4ClO3P

MW: 142.48

EINECS: 229-560-6

 

2-Chloro-1,3,2-dioxaphospholane-2-oxide Chemical Properties

Melting point 12-14 °C

Boiling point 89-91 °C0.8 mm Hg(lit.)

density 1.55 g/mL at 25 °C(lit.)

vapor pressure 1.06hPa at 25℃

refractive index n20/D 1.45(lit.)

Fp >230 °F

storage temp. -20°C

solubility Chloroform (Soluble), Ethyl Acetate (Slightly)

form Solid or Film

color White to off-white

Water Solubility Miscible with water and chloroform.

Sensitive Moisture Sensitive

BRN 606582

Stability: Extremely moisture sensitive

InChIKey SBMUNILHNJLMBF-UHFFFAOYSA-N

LogP -0.485 at 25℃ and pH7

 

Chemical Properties clear colourless liquid

Uses 2-Chloro-1,3,2-dioxaphospholane-2-oxide is used in the synthesis of α-naphthylphosphorylcholine as a method to detect phospholipase C activity.

Uses Ethylene chlorophosphate is used in the syntheses of 2-methacryloyoxyethylphophocholine, phosphatidylcholines, 2',3'-O-16-hentriacontanyliden-adenosine-5'-phosphocholine and hexadecylphosphocholine. It is also involved the synthesis of alpha-naphthylphosphorylcholine, which is used to detect phospholipase C activity. It is an important reactant for the synthesis of a zwitterionic silane, UV-polymerizable lipids utilizing Chabrier reaction and block copolymers of poly(aliphatic ester) clickable polyphosphoester.

Uses 2-Chloro-1,3,2-dioxaphospholane 2-oxide may be used in the synthesis of:

2-methacryloyloxyethylphosphorylcholine

miltefosine (hexadecylphosphocholine, MT) analogs

phosphoric acid 2-trimethylamino-ethyl ester undec-10-enyl ester

uridine nucleolipid, (2′,3′-O-16-hentriacontanyliden-uridine-5′-phosphocholine, PUPC)

adenosine nucleoamphiphile, (2′,3′-O-16-hentriacontanyliden-adenosine-5′-phosphocholine, PAPC)

structurally related phospholipids which are either conformationally restricted or flexible

phosphatidylcholines