Details:

Our advantage:

1. High quality with competitive price:

1) Standard:BP/USP/EP/Enterprise standard

2) All Purity≥99%

3) We are manufacturer and can provide high quality products with factory price.

 2, Fast and safe delivery

1) Parcel can be sent out in 24 hours after payment.Tracking number available

2) Secure and discreet shipment.Various transportation methods for your choice.

3) Customs pass rate ≥99%

4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe,

and we have stock in there for transferring.

Molar Mass	463.36854
Water Solubility	Soluble in water.
Solubility	Soluble in water, insoluble in organic solvents such as ethanol, acetic acid and acetone.
Appearance	White or yellowish acne powder
Color	White to Off-white
Storage Condition	Store at RT.
Sensitive	Sensitive to light
MDL	MFCD00146419
Physical and Chemical Properties	White or yellowish amorphous powder. Easily soluble in water, insoluble in organic solvents. It is hygroscopic, odorless and tasteless.
Use	For the treatment of coronary atherosclerosis, high cholesterol, high cholesterol, angina, myocardial ischemia, myocardial infarction

Product Packaging：

1) 1kg/bag (1kg net weight, 1.1kg gross weight, packed in an aluminum foil bag)

2) 25kg/drum (25kg net weight, 28kg gross weight; Packed in a cardboard-drum with two plastic-bags inside; Drum Size: 510mm high, 360mm diameter)

 Storage：

Stored in a cool and dry well-closed container. Keep away from moisture and strong light/heat.

Delivery：

Usually within3-5 working days after full payment.

transport：

EMS,DHL, TNT, UPS ,FEDEX, BY AIR, BY SEA

DHL Express, FedEx and EMS for quantity less than 50KG, usually called as DDU service; 

Sea shipping for quantity over 500KG; And air shipping is available for 50KG above;

For high value products, please select air shipping and DHL express for safe;

Our Service:
1. Fast Delivery: We can delivery within 24 hours upon receipt of your payment.
2. Quality can be promised. Hot sell to Worldwide.
3. Payment Terms: T/T,, t/t
4. Free Sample available at any time.
5. Tracking your order at any time. Inform your order's further new situation at any time.
6. Package: Professional packing with professional materials.

Introduction	chondroitin sulfate (CS) is an acidic mucopolysaccharide extracted and purified from animal cartilage tissue. Chondroitin sulfate A,C,D,E,H and K and other different structures, nature of chondroitin sulfate exists in animal cartilage, throat bone, nasal bone (pigs contain 41%), cattle, horses in the diaphragm and trachea (including 36% a 39%), other such as leg bones, ligaments, skin, cornea and other tissues also contain. The content of fish cartilage is very rich, such as shark bone containing 50% ~ 60%, the content of connective tissue is very small.
Clinical application	1. Chondroitin sulfate as a health food or health care drugs used in the prevention and treatment of coronary heart disease, angina pectoris, myocardial infarction, coronary atherosclerosis, myocardial ischemia and other diseases, no significant side effects, can significantly reduce the Incidence Rate and Mortality Rate of patients with coronary heart disease. Long-term clinical application has found that lipids such as fat deposited on the walls of arteries and veins can be effectively removed or reduced, and plasma cholesterol can be significantly reduced, thereby preventing the formation of atherosclerosis. Chondroitin sulfate for the treatment of neuropathic pain, migraine, Arthralgia, arthritis and scapular Arthralgia, abdominal pain after surgery. Prevention and Treatment of streptomycin-induced hearing disorders and a variety of noise-induced hearing difficulties, tinnitus, etc., the effect is significant. 4. For chronic nephritis, chronic hepatitis, keratitis and corneal ulcer and other adjuvant therapy. In recent years, it has been reported that chondroitin in shark cartilage has anti-tumor effect. In addition, chondroitin sulfate is also applied to cosmetics and wound healing agents. 6. Chondroitin sulfate is also used in eye drops.
pharmacological action	chondroitin sulfate exists widely in human and animal cartilage tissue. The pharmaceutical preparation mainly contains two isomers of chondroitin sulfate A and chondroitin sulfate C, and the content of chondroitin sulfate in cartilage of different species, ages and other animals is different. Its pharmacological effects are as follows: 1. Chondroitin sulfate can remove lipids and lipoproteins in the blood, remove cholesterol from blood vessels around the heart, prevent and treat atherosclerosis, and increase the conversion rate of lipids and fatty acids in cells. 2, chondroitin sulfate can effectively prevent coronary heart disease. Experimental atherosclerosis model with anti-atherosclerosis and anti-atherogenic plaque formation; Increased coronary artery atherosclerosis or collateral circulation, it can accelerate the healing, regeneration and repair of myocardial necrosis or degeneration caused by experimental coronary arteriosclerosis or embolism. 3, can increase the cell's messenger ribonucleic acid (mRNA) and deoxyribonucleic acid (DNA) biosynthesis and promote cell metabolism. 4, low anticoagulant activity. Chondroitin sulfate has a moderate anticoagulant effect, and the anticoagulant activity per 1 mg of chondroitin sulfate A is comparable to 0.45U of heparin. This anticoagulant activity does not depend on antithrombin III and exerts its anticoagulant activity through the fibrinogen system. 5, chondroitin sulfate also has anti-inflammatory, accelerate wound healing and anti-tumor and other aspects of the role. (1) chondroitin sulfate for the treatment of coronary heart disease has the effect of clarifying lipid. Health food and medicine developed with chondroitin sulfate as raw material have been used for a long time to prevent coronary heart disease, angina pectoris, myocardial infarction, coronary atherosclerosis, myocardial ischemia and other diseases, clinical application found no obvious side effects, can significantly reduce the Incidence Rate and Mortality Rate of patients with coronary heart disease. (2) improving joint problems chondroitin sulfate used in combination with glucosamine can promote cartilage regeneration and soften bones, and is clinically used as a commonly used drug for treating joint diseases, which can effectively improve joint problems. (3) Protect bone chondroitin sulfate can prevent bone calcification, prevent bone hardening and brittle, promote the stiffness of bone flexibility; In addition, chondroitin sulfate can also within a certain range to reduce the hardening and brittleness of the expanded state of bone contour, effectively improve bone hyperplasia. (4) to promote the healing of corneal wound and improve the symptoms of ocular dryness chondroitin sulfate can improve corneal blood circulation, accelerate metabolism, enhance permeability, promote the absorption of corneal stroma in The exudate and fiber growth, elimination of inflammation, has a protective effect on corneal collagen fibers; Secondly, chondroitin sulfate can improve the water metabolism of corneal tissue, promote the formation of a layer of breathable water-retaining membrane on the surface of the cornea, promote corneal wound healing and improve ocular dryness symptoms.
preparation	dilute alkali-enzymatic extraction method: firstly, boil the cartilage at 80 ℃ for 4~6 h, then NaOH is added according to the ratio of raw material (dry weight) and 2%NaOH, which is l:6.25, extracted at room temperature for 1.5 h, then adjusted to pH 6~6.5 with HC1, and filtered with double-layer gauze; the filtrate was left, and the filter residue was added with 2%NaOH at a ratio of 1:0.12, extracted at 40 ° C. For 1 h, and then filtered with a double layer filter cloth; The filter residue was discarded, and the filtrate was taken. Two filtrates were combined and the volume was measured until use. Adjust the pH of the filtrate to 8.0~9.0, add Pancreatin according to the ratio of filtrate and Pancreatin 1 000:0, 5, and hydrolyze l at 40~50 ℃ for 1 h, then press 1 000:0.5 of the proportion of the addition of pepsin, 40~50 oC hydrolysis 1.5 h. After filtration, kaolin and activated carbon were added for adsorption. The filtrate was extracted by a chloroform back-extraction method, and the aqueous layer was retained. The pH of the water layer was adjusted to 6.8-7.2, and then 2.5 times the volume of 95% 1-2 ethanol was added to precipitate, to obtain the chondroitin sulfate.
Overview	white powder at room temperature, odorless, tasteless, strong water absorption, soluble in water and a solution of high viscosity, it is unstable at higher temperatures or acids, mainly deacetylation or degradation into monosaccharides or polysaccharides of lower molecular weight. Do not dissolve in ethanol, acetone and ether and other organic solvents, the salts of heat more stable, heated 80 ° C also does not destroy. chondroitin sulfate is A mixed acid mucopolysaccharide extracted from cartilage of pig, cow, chicken and shark. According to the difference of chemical composition and structure, it is divided into A, B, C, D, E, F, H and other. It mainly contains chondroitin sulfate A and chondroitin sulfate C and other mucopolysaccharide components. Chondroitin sulfate A and C both contain D-glucuronic acid and 2-hydro-deoxy-d-galactose, and containing equal amounts of acetyl and sulfuric acid residues, the difference between the two structures is only in the amino hexose residue on the different position of the sulfate ester. Chondroitin sulfate A can enhance the activity of lipase, the decomposition of triglycerides in chylomicrons, chylomicrons in blood to reduce and clarify. It has anticoagulant and antithrombotic effects, clinical for the treatment of coronary atherosclerosis, blood lipids and cholesterol, angina, neuralgia, myocardial ischemia and myocardial infarction. Can also be used for the prevention and treatment of streptomycin caused by hearing disorders and migraine, nerve pain, elderly shoulder pain, back pain, arthritis and hepatitis and skin cosmetics. According to reports, chondroitin sulfate can also effectively improve the repair of articular cartilage, synovial, maintain lubrication between articular cartilage, make it elastic, improve joint pain, inflammation and other symptoms. At the same time, it also has special effects on tendon, ligament, diaphragm cardiovascular and other diseases. chondroitin sulfate is also one of the important components in the eye tissue, with the function of promoting corneal water metabolism, improving microcirculation, protecting cornea and promoting corneal tissue damage repair, at the same time, it can also form a protective film on the surface of the cornea to prevent water distribution and effectively relieve the symptoms of asthenopia and dry eye; Aminoethanesulfonic acid can not only be antibacterial and anti-inflammatory, but also participate in a variety of physiological activities in eye tissues, promote metabolism and improve asthenopia.
Role	1, chondroitin sulfate is extracted from animal cartilage mucopolysaccharides, in cardiovascular disease, it plays an important role in the prevention and treatment of joint disease, and is a more important biochemical product in the current market. 2, as a health food or health care drugs, chondroitin sulfate has long been used in the prevention and treatment of coronary heart disease, angina pectoris, myocardial infarction, coronary atherosclerosis, myocardial ischemia and other diseases, without obvious toxic and side effects, can significantly reduce the Incidence Rate and Mortality Rate of patients with coronary heart disease. Long-term clinical application has found that lipids such as fat deposited on the walls of arteries and veins can be effectively removed or reduced, and plasma cholesterol can be significantly reduced, thereby preventing the formation of atherosclerosis. 3, chondroitin sulfate for the treatment of neuropathic pain, migraine, Arthralgia, arthritis and scapular Arthralgia, abdominal pain after surgery. 4, prevention and treatment of streptomycin-induced hearing disorders and a variety of noise-induced hearing difficulties, tinnitus, etc., the effect is significant. 5. It has adjuvant therapeutic effect on chronic nephritis, chronic hepatitis, keratitis and corneal ulcer. 6. In recent years, it has been reported that chondroitin in shark cartilage has anti-tumor effect. In addition, chondroitin sulfate is also applied to cosmetics and wound healing agents. Chondroitin sulfate is an acidic mucopolysaccharide, is one of the important components in the eye tissue, with the promotion of corneal water metabolism and improvement, suitable for asthenopia, dry eye. Figure 1 is a physical picture of chondroitin sulfate products provided by Sigma, USA.
pharmacology and toxicology	chondroitin sulfate widely exists in human and animal cartilage tissue. The pharmaceutical preparation mainly contains two isomers of chondroitin sulfate A and chondroitin sulfate C, and the content of chondroitin sulfate in cartilage of different species, ages and other animals is different. Its pharmacological effects are as follows: chondroitin sulfate can remove lipids and lipoproteins in the blood, remove cholesterol from blood vessels around the heart, prevent and treat atherosclerosis, and increase the conversion rate of lipids and fatty acids in cells. Chondroitin sulfate can effectively prevent and treat coronary heart disease. Experimental atherosclerosis model with anti-atherosclerosis and anti-atherogenic plaque formation; Increased coronary artery branch or collateral circulation, it can accelerate the healing, regeneration and repair of myocardial necrosis or degeneration caused by experimental coronary arteriosclerosis or embolism. It can increase the biosynthesis of messenger ribonucleic acid (mRNA) and deoxyribonucleic acid (DNA) of cells and promote the metabolism of cells. Low anticoagulant activity. Chondroitin sulfate has a moderate anticoagulant effect, and the anticoagulant activity per 1 mg of chondroitin sulfate A is comparable to 0.45U of heparin. This anticoagulant activity does not depend on antithrombin III to play a role, it can play an anticoagulant activity through the fibrinogen system. Chondroitin sulfate also has anti-inflammatory, accelerated wound healing and anti-tumor effects.
Chondroitin Sulfate Injection instructions	Common name: Chondroitin Sulfate Injection English name: clondroitin Sulfate Injection: injection [ingredients] chondroitin sulfate sodium salt. [Properties] This product is colorless or yellowish clear liquid. [Pharmacology and Toxicology] chondroitin sulfate widely exists in human and animal cartilage tissue. Its pharmacological preparations mainly contain two isomers of chondroitin sulfate A and chondroitin sulfate C. Experimental animal atherosclerosis model shows: the goods have anti-atherosclerosis and anti-atherosclerotic plaque formation. Increase coronary artery branch or collateral circulation, and can accelerate the healing, regeneration and repair of myocardial infarction or degeneration caused by experimental coronary arteriosclerosis or embolism. This product has a relaxation and anticoagulant effect, each 1mg chondroitin sulfate a phase when 0.45U anticoagulant activity of heparin. This anticoagulant wash does not depend on antithrombin III to play a role, it can play an anticoagulant activity through the fiber protein system. [Pharmacokinetics] after 4 hours of administration, the blood concentration of the peak, the half-life of about 7 hours, about 50% from the urine excretion. In vivo distribution of such as bone tissue, blood vessel wall, brain, connective tissue. [Indications] apply to nerve headache, neuralgia, Arthralgia, arteriosclerosis and other diseases. Dosage: intramuscular injection. 1-2 times a day, 2ml (one at a time). [Adverse reactions] Individual chest tightness, Nausea, a small amount of bleeding gums. [Contraindications] The goods have a history of allergy with caution. [Note] there is a tendency to bleeding with caution, when the drug properties change is prohibited. [Pregnant and lactating women] is not clear.
uses	for patients with coronary heart disease coronary atherosclerotic disease, elevated blood lipids and cholesterol, atherosclerosis, angina, myocardial ischemia, myocardial infarction and other symptoms. for the treatment of coronary atherosclerosis, hyperlipidemia, high cholesterol, angina, myocardial ischemia, myocardial infarction and other diseases
production method	the pig throat and nasal cartilage were extracted with 2% sodium hydroxide, the extract was hydrolyzed with crude trypsin at 50 °c to remove impurities such as proteins. After filtration, the pH of the enzymatic hydrolysate was adjusted to 6, and ethanol was added to a concentration of 75%. Centrifugation gave the precipitate, the crude chondroitin sulfate product. The finished product was obtained by multi-step refining. The total yield of the pig throat and nasal cartilage was 5%.

Packing:  
  1. Inner double plastic bags----25kg/Fiber drum (35*35*45cm, GW: 28kg, NW: 25kg); 

  2. Inner double plastic bags----5kg/Aluminum foil bag (GW: 6.5kg, NW: 5kg). 

  3. Inner double plastic bags----1kg/Aluminum foil bag (GW: 1.5kg, NW: 1kg). 

P.S.: we accept packaging customization. 

  
Delivery:   

  1. Stock products are normally shipping within 3 working days.  

  2. For rush delivery, please contact our sales team for particular arrangement. 

Shipping Details: 
  1. We ship goods via DHL, Fedex, UPS, TNT, China post, NL Post and other couriers, weight from 10g to 1000kg or even bulker. 

  2. Shipping details & shipping documents will be provided and sent by email. 

  3. We keep tracking the shippment until clients well received. 

  4. After years export shipping experience, with professional and experienced cooperated forwarders, we ensure that goods can be delivered in multiple ways safetly and efficiently. 

About us

Our company specializes in processing and selling chemical raw materials, chemical products, pharmaceutical intermediates, veterinary medicine intermediates, dye intermediates, pigments, cosmetics raw materials and chemical reagents,  

We have compalete sales and service team , information feedback vertical integration of a sound marketing network, products are sold throughout the country and exported to South Asia, Europe, America, Africa and other more than 20 countries and regions.  

Companies adhering to the "pursuit of quality, innovation and development" business philosophy, to serve as a foundation, for the survival by the quality, seek development by science and technology, adhere to quilty comes first,fair price,good sense of customer service and responsibility. in the future hebei Nengqian import and export trade Co.,Ltd will always hold "integrity, innovation" business philosophy, to achieve honesty management, on the way of specialization, internationalization,  Keep moving!  

 

FAQ: 
1. Are you a trade company or factory   
We are a  factory with our own trading company.  

2.How do you control the quality   
Our factory is equipped with professional technicians to control quality, out inspectors take sample for testing every 2 hours to ensure the quality of our production. We also accept BV, SGS or any other Third-party inspection.   

3. How long is lead time   
We deliver goods within 3 days for small order, 7-10 days for bulk order.   

4. Where is your factory located  How can I visit the factory   
 Our factory located in HEBEI, China.

5. Can i get some samples  
  Yes, we can supply free sample, but the shipping cost be paid by our customers. 

6. How to start orders or make payments  
  Proforma invoice will be sent first after confirmation of order, enclosed our bank information.Payment by T/T,  

7. How to confirm the Product Quality before placing orders  
  You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. 
  You can send us your product specifications and requests,we will manufacture the products according to your requests. 

8. How long is lead time

We deliver goods within 3 days for small order, 7-10 days for bulk order.

 

9. How do you treat quality complaint

  First of all, our quality control will reduce the quality problem to near zero. If there is a realquality problem caused by us, we will send you free goods for replacement or refund your loss.