CasNo.27143-07-3,Chloro[(4-methoxyphenyl)hydrazono]acetic acid ethyl ester,(27143-07-3) Suppliers

1 Kilogram	Negotiable

Min.Order :1 Kilogram
Purity: 99.9% by HPLC
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Keywords

Chloro[(4-methoxyphenyl)hydrazono]acetic acid ethyl ester Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate Apixaban intermediate

Quick Details

Appearance:White crystallization
Application:Butyldimethylsilyloxyethylcarboxyet
PackAge:25kg/drum
ProductionCapacity:10|Metric Ton|Day
Storage:
Transportation:AIR SEA TRAIN

Superiority:

Product Name:	Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate
Synonyms:	2-chloro-2-[2-(4-methoxyphenyl)hydrazinylidene];ethyl 2-chloro-2-[(4-methoxyphenyl)hydrazinylidene]acetate;Apixaban Impurity B;(Z)-Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate (Apixaban);Apixaban-2;1-(4-methoxyphenyl)-4-(2-((4-(2-oxopiperidin-1-yl)phenyl)amino)ethyl)-1H-pyrazole-3,5-dicarboxamide;Chloro[(4-methoxyphenyl)hydrazono]acetic acid ethyl ester;Ethyl chloro[(4-methoxyphenyl)hydrazono]acetate
CAS:	27143-07-3
MF:	C11H13ClN2O3
MW:	256.69
EINECS:	608-053-7
Product Categories:	27143-07-3
Mol File:	27143-07-3.mol

Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate Chemical Properties

Melting point	94℃
Boiling point	349.0±44.0 °C(Predicted)
density	1.23
storage temp.	2-8°C
solubility	Chloroform (Sparingly), Methanol (Slightly)
form	Solid
pka	11.63±0.10(Predicted)
color	Yellow to Dark Yellow

Details:

Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate Usage And Synthesis

Physical properties	Light yellow to dark yellow solid
Uses	Acetic acid, 2-chloro-2-[2-(4-methoxyphenyl)hydrazinylidene], ethyl ester is an ester derivative and can be used as an intermediate in the synthesis of apixaban.
Synthesis	Step-1:Water (600 ml) was added to p-anisidine (100 g) at room temperature and the resulting mixture was cooled to 10°C, followed by the addition of concentrated hydrochloric acid (133.5 g). The resulting mixture was cooled to —5°C to 0°C, followed by portion-wise addition of 40 % aqueous sodium nitrite solution over 45 minutes to 1 hour. The resulting mass was stirred for 1 hour 30 minutes at —5°C to0°C, followed by slow addition of 11 % sulfamic acid solution over 1 hour to 1 hour 30 minutes to produce a reaction mass (first part).Step-2:Sodium acetate (146 g) was added to water (300 ml) at room temperature and then stirred for 10 minutes to 15 minutes, followed by the addition of ethyl 2-chloroacetoacetate (160.4g) and acetone (300 ml) at room temperature to form a reaction mixture. The resulting mixture was cooled to 0°C. The resulting mixture was added to the reaction mass (first part) obtained in step-i at —5°C to 0°C and then stirred for 1 hour at the same temperature. Acetone (200 ml) was added to the resulting mass and stirred for 30 minutes at —5°C to 0°C. The resulting mass was settled for 5 hours at —5°C to 0°Cand then filtered the solid. Methanol (150 ml) was added to the resulting solid at room temperature and then stirred for 2 hours at the same temperature. Ethyl 2-chloro-2-(2-(4-methoxyphenyl) hydrazone)acetate was obtained through further purity.