Dxd-D5

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Purity: 98.63%

Keywords

N-[(10S,23S)-18-fluoro-10-hydroxy-19-methyl-5,9-dioxo-10-(1,1,2,2,2-pentadeuterioethyl)-8-oxa-4,15-diazahexacyclo[14.7.1.02,14.04,13.06,11.020,24]tetracosa-1,6(11),12,14,16,18,20(24)-heptaen-23-yl...

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Application:For research use only.
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Storage:4°C, sealed storage, away from moisture and light; in solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Dxd-D5 (Exatecan-D5 derivative for ADC) is a tritiated version of Dxd. Dxd is a potent DNA topoisomerase I inhibitor with IC50 of 0.31 μM, which can be used as a payload of an antibody drug-conjugated ADC (DS-8201a) targeting HER2.

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