FR-901463 6-[(1E,3E)-5-(5-{[(2Z)-4-(acetyloxy)pent-2-enoyl]amino}-3,6-dimethyltetrahydro-2H-pyran-2-yl)-3-methylpenta-1,3-dien-1-yl]-4-C-(chloromethyl)-1,3-dideoxy-alpha-D-erythro-hex-2-ulopyranose
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a potent cell cycle inhibitor. Fr901463 exhibited potent antitumor activities against tumor cell lines via binding to the spliceosome and modulating pre-mRNA splicing.
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