Antagonist G

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Purity: 98%

Keywords

[Arg6,D-Trp7,9,N-MePhe8]-Substance P(6-11)

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Application:For research use only.
PackAge:1 mg
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Storage:Store at -20°C
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Antagonist G is a substance P analog, which is a broad spectrum neuropeptide growth factor antagonist and antiproliferative agent. It was developed for the treatment of small cell lung cancer. It could inhibit neuropeptide-dependent and -independent proliferation of small cell lung cancer in vitro. It also inhibits growth of SCLC xenografts in mice in vivo. It blocks Swiss 3T3 cell growth induced by vasopressin, gastrin-releasing peptide and bradykinin. It activates JNK and stimulates apoptosis. It is an anticancer agent and is resistant to degradation by peptidases.

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