Semaxinib

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Purity: 98%

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SU5416 SU-5416

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Appearance:Yellow to Orange Solid Powder
Application:Angiogenesis Inhibitors
PackAge:100 mg
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Semaxinib is a quinolone derivative with potential antineoplastic activity. Semaxinib reversibly inhibits ATP binding to the tyrosine kinase domain of vascular endothelial growth factor receptor 2 (VEGFR2), which may inhibit VEGF-stimulated endothelial cell migration and proliferation and reduce the tumor microvasculature. This agent also inhibits the phosphorylation of the stem cell factor receptor tyrosine kinase c-kit, often expressed in acute myelogenous leukemia cells.

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