1-Propanone,1-(4-hydroxyphenyl)-3-(2,4,6-triMethoxyphenyl)
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Loureirin B, isolated from the herbs of Dracaena cochinchinensis, is a channel blocker of Kv1.3 by interacting with amino acid residues in its selective filter region. Direct inhibition of Kv1.3 in T cells by SD and Loureirin B might be the cellular and molecular basis of SD-mediated immunosuppression. Loureirin B could evoke the elevation of [Ca(2+)](i) in a dose-dependent manner. Loureirin B is also the effective component in dragon's blood modulating sodium currents in trigeminal ganglion neurons.
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