3-(4-Hydroxyphenyl)-5,7-dihydroxy-6-(3-methyl-2-butenyl)-4H-1-benzopyran-<br/>4-one 4',5,7-Trihydroxy-6-(3-methyl-2-butenyl)isoflavone
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Wighteone, also called Erythrinin B, is a natural flavonoid isolated from the herbs of Glycyrrhiza glabra, has a potent anti-proliferative effect on human leukemia HL-60 cancer cell lines, it can effectively inhibit the proliferation of HER2-positive cancer cell lines, which is considered to be the result of downregulating HSP90 receptor and downstream signaling. Wighteone also exhibits cytocidal activity against KB cells in vitro.
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