5-(Hydroxymethyl)-2'-deoxyuridine

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Min.Order :0
Purity: ≥95%

Keywords

a-hydroxythymidine 5-Hydroxymethyl-2'-deoxyuridine

Quick Details

Appearance:White to Off-white Solid
Application:Antineoplastic Agents
PackAge:1 g
ProductionCapacity:
Storage:Store at -20°C under inert atmosphere
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5-(Hydroxymethyl)-2'-deoxyuridine is a nucleoside analog with anticancer and antiviral activities. It inhibits the replication of murine S180 lung carcinoma cells and Ehrlich ascites mammary carcinoma cells (ED50s = 8.5 and 4 μM, respectively) and multiple human leukemia cell lines (IC50s = 1.7-5.8 μM). 5-(Hydroxymethyl)-2'-deoxyuridine acts synergistically with 5-fluorouracil (5-FU) against HT-29, HCT116, PANC-1, and EKVX cancer cells with no effect on WI38 embryonic lung fibroblasts.

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