JK-184

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Purity: 98%

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JK184 JK 184

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Appearance:Light pink color
Application:Differentiation
PackAge:100 mg
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JK-184 is a potent downstream hedgehog (Hh) signaling antagonist that functions by alcohol dehydrogenase 7 (Adh7) inhibition, preventing Gli-dependent transcriptional activity (IC50 = 30 nM). Hedgehog signaling plays a key role in a wide variety of developmental processes as well as cancer progression. JK-184 exhibits antiproliferative activity.

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