TPX-0005 TPX 0005
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TPX-0005 is an orally available and potent ATP-competitive inhibitor of ALK/ROS1/TRK (IC50= 5.3 nM for SRC, IC50= 1.01 nM, 1.26 nM and 1.08 nM for mutant ALKs including WT ALK, ALK G1202R and ALK L1196M, respectively).
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