Deaza-Ado (2R,3R,4S,5R)-2-(4-Amino-1H-imidazo[4,5-c]pyridin-1-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
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3-Deazaadenosine (3-DZA) is an inhibitor of SAH hydrolase (Ki = 3.9 μM). 3-Deazaadenosine is a modified form of the nucleoside adenosine, where a nitrogen atom in the purine ring is replaced with a carbon atom. This modification results in the compound lacking the ability to form hydrogen bonds with complementary nucleotides, making it useful in studying the role of hydrogen bonding in nucleic acid structure and function. 3-Deazaadenosine has been investigated for its potential therapeutic applications, such as in the treatment of viral infections and cancer. It is also used as a biochemical tool in research to study RNA interactions and enzymatic mechanisms.
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