cADPR Adenosine 5'-(trihydrogen diphosphate), 1-b-D-ribofuranosyl-, intramol, P',5''-ester
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Cyclic ADP-ribose is a potent calcium-mobilized second messenger synthesized from NAD+ by ADP-ribosyl cyclase. It increases cytosolic calcium mainly by Ryanodine receptor-mediated release from endoplasmic reticulum and extracellular influx through the opening of TRPM2 channels.
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