Phytolaccasaponin E Phytolaccoside E
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Esculentoside A, that is found in the roots of Phytolacca acinosa Roxb, suppressed inflammatory responses in LPS-induced ALI through inhibition of the nuclear factor kappa B and mitogen activated protein kinase signaling pathways. Esculentoside A may be a promising potential preventive agent for ALI treatment. Esculentoside A treatment attenuated CCl4 and GalN/LPS-induced acute liver injury in mice and its protective effects might be involved in inhibiting inflammatory response and oxidative stress. Esculentoside A may also be useful for the treatment of autoimmune disease through modulation on T cell-mediated adaptive immunity.
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