5'-Phosphoribosylglycinamide N1-(5-Phospho-D-ribosyl)glycinamide
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Glycineamide ribonucleotide (or GAR) is an intermediate in de novo purine biosynthesis. It is formed from phosphoribosylamine by the enzyme phosphoribosylamine-glycine ligase. In the next step of purine biosynthesis the enzyme phosphoribosylglycinamide formyltransferase acts on GAR to form FGAR. GAR formation is stimulated by Luteinizing hormone (LH) and Chorionic gonadotropin (HCG) via activation of Glc-6-P-dehydrogenase.
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