Rp-8-pCPT-cGMPS

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Purity: ≥ 99% by HPLC

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8- (4- Chlorophenylthio)guanosine- 3', 5'- cyclic monophosphorothioate, Rp- isomer, sodium salt

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Rp-8-pCPT-cGMPS is a selective inhibitor of protein kinase G I a, I ? and especially of type II, which stimulates retinal cGMP channels and discriminates between kinase and channel effects. It effects against mammalian cyclic nucleotide-dependent phosphodiesterases. Compared to Rp-cGMPS or Rp-8-Br-cGMPS, it exhibits more lipophilic and membrane-permeant properties.

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