Ponatinib-[d8]

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Purity: 95% by HPLC; 95% atom D

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Ponatinib D8 3-(2-imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methyl-1-piperazinyl-2,2,3,3,5,5,6,6-d8)methyl]-3-(trifluoromethyl)phenyl]-benzamide

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Ponatinib-[d8] is the labelled analogue of Ponatinib, which is a novel, potent multi-target inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src with IC50 of 0. 37 nM, 1. 1 nM, 1. 5 nM, 2. 2 nM and 5. 4 nM, respectively.

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