Agomelatine-[d4]

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N-[2-(7-Methoxy-1-naphthalenyl)ethyl-d4]acetamide N-[2-(7-Methoxy-1-naphthyl)-ethyl]acetamide-d4

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Agomelatine-[d4] is a labelled Agomelatine. Agomelatine is a melatoninergic agonist and selective antagonist of 5-HT2C receptors, and has been shown to be active in several animal models of depression. Agomelatine displayed pKi values of 6.4 and 6.2 at native (porcine) and cloned, human (h)5-hydroxytryptamine (5-HT)2C receptors, respectively.

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Agomelatine-[d4]

Agomelatine-[d4]

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H-TYR-LYS-OH

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Agomelatine-[d4]

Agomelatine-[d4]

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H-Tyr-Leu-Ala-Asp-Gly-Asp-Leu-His-Ser-Asp-Gly-Pro-Gly-Arg-OH

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