Ac-Nle-Pro-Nle-Asp-...

Ac-Nle-Pro-Nle-Asp-AMC

Ac-Nle-Pro-Nle-Asp-AMC

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  • Min.Order :0
  • Purity: ≥98%

Keywords

Ac-Nle-Pro-Nle-Asp-7-amido-4-Methylcoumarin Ac-nLPnLD-AMC

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  • Appearance:White Lyophilized Powder
  • Application:For research use only.
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  • Storage:Store at -20°C
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Details:

Ac-Nle-Pro-Nle-Asp-AMC is a substrate for proteasomes. It can be cleaved by the caspase-like site of proteasome, also known as postglutamyl peptide hydrolase (PGPH). AMC (7-amino-4-methylcoumarin) is released and produces the fluorescence utilized to quantify the caspase-like site activity. Ac-Nle-Pro-Nle-Asp-AMC also inhibits the chymotrypsin-like activity of the proteasome allosterically when bound to the caspase-like site.

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