CasNo.11011-38-4,Pimecrolimus intermediate,(11011-38-4) Suppliers

1 Kilogram	Negotiable

Min.Order :1 Kilogram
Purity: 99.9% by HPLC
Payment Terms : L/C,T/T,Other

Keywords

(3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-8-Ethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-1 Ascomycin 11011-38-4

Quick Details

Appearance:White crystallization
Application:Butyldimethylsilyloxyethylcarboxyet
PackAge:25kg/drum
ProductionCapacity:10|Metric Ton|Day
Storage:
Transportation:AIR SEA TRAIN

Superiority:

Ascomycin Basic information

Product Name:	Ascomycin
Synonyms:	ASCOMYCIN, STREPTOMYCES HYGROSCOPICUS;ASCOMYCIN, STREPTOMYCES HYGROSCOPICUS VAR ASCOMYCETICUS;FR-900520;FK-520;IMMUNOMYCIN;AAG;ASCOMYCIN (IMMUNOMYCIN, FR-900520) \ INH IBITS CALCINEURIN (PP2B);(3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-8-Ethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone
CAS:	11011-38-4
MF:	C43H69NO12
MW:	792.01
EINECS:	658-052-0
Product Categories:	API;Immunosuppressant
Mol File:	11011-38-4.mol

Ascomycin Chemical Properties

Melting point	158 - 161°C
storage temp.	-20°C
solubility	Soluble in DMSO (up to 50 mg/ml), or in Ethanol (up to 50 mg/ml with warming).
form	White crystalline solid
color	White
Stability:	Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.

Details:

Ascomycin Usage And Synthesis

Description	Ascomycin (11011-38-4) is an analog of FK-506 (Cat.# 10-1103). Potent immunosuppressant1. Binds to FKBP122 and inhibits calcineurin and NFAT. Ascomycin displays anti-inflammatory effects in skin diseases3. Cell permeable and active in vivo.
Uses	A potent immunosuppressive agent and could be used as a potential therapeutic agent for autoimmune diseases.
General Description	An ethyl analog of FK506 with similar immunosuppressant properties. Acts by binding to immunophilins. Inhibits the synthesis of Th-1 and Th-2 type cytokines in target cells.
Biochem/physiol Actions	Product does not compete with ATP.
Enzyme inhibitor	This antifungal antibiotic (FW = 792.02 g/mol; CAS 104987-12-4; Solubility: 50 mM in DMSO), also known as FK520, isolated from Streptomyces hygroscopicus, is also a powerful immunosuppressant. Note that ascomycin is a structural analogue of tacrolimus (or FK506) and, as such, operates by a similar mechanism of action (See Tacrolimus). Ascomycin inhibits allogenic T-lymphocyte proliferation and calcineurin phosphatase activity.