Details:

Our advantage:

1. High quality with competitive price:

1) Standard:BP/USP/EP/Enterprise standard

2) All Purity≥99%

3) We are manufacturer and can provide high quality products with factory price.

 2, Fast and safe delivery

1) Parcel can be sent out in 24 hours after payment.Tracking number available

2) Secure and discreet shipment.Various transportation methods for your choice.

3) Customs pass rate ≥99%

4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe,

and we have stock in there for transferring.

Melting Point	300 °C
Boling Point	273-281 °C
Specific Rotation(α)	D26 +8.5° (c = 0.8)
Water Solubility	>=1 g/100 mL at 24 ºC
Solubility	Soluble in water, insoluble in petroleum ether.
Appearance	White crystal
Color	white to off-white
BRN	3924631
Storage Condition	Sealed in dry,Store in freezer, under -20°C
Stability	Stable for 2 years from date of purchase as supplied. Solutions in distilled water may be stored at -20° for up to 3 months.
MDL	MFCD00084729
Physical and Chemical Properties	Melting point 273-281°C water-soluble> = 1g/100 mL at 24°C

Introduction	Vincristine (Vincristine), trade name "Viscine", "Ankeping" (Oncovin), also known as vincristine, Neovinblastine, medically referred to as VCR, is an alkaloid extracted from periwinkle, a plant of the genus Oleaceae. It is a mitotic inhibitor that is widely used in chemotherapy to treat a variety of cancers, including acute lymphoblastic leukemia, acute myeloid leukemia, Hodgkin's lymphoma, neuroblastoma, and small cell lung cancer. Vincristine sulfate is its sulfate form.
pharmacological action	vincristine sulfate (vincristinesulfate,VCR) is a cell cycle specific anti-tumor drug of periwinkle alkaloids of Apocynaceae. The anti-tumor target is microtubules, which mainly inhibit the polymerization of tubulin and affect the formation of spindle microtubules, so that mitosis stops in the metaphase.
clinical application	like other periwinkle alkaloids, VCR has a good therapeutic effect on many malignant tumors of lymphoid tissues, including invasive non-Hodgkin lymphoma and acute lymphoblastic leukemia. It is mainly used in the treatment of acute leukemia, malignant lymphoma, neuroblastoma, chronic lymphocytic leukemia and other diseases.
prepare	2g of vinblastine sulfate dissolved in 240ml of tetrahydrofuran, add 7.5ml of glacial acetic acid, under its protection, cool down to -65 ℃ with dry ice, under stirring, add the prepared sodium dicadmium solution (3g of sodium dicadmium dissolved in 15ml of water, then add 2ml of concentrated sulfuric acid, stir and dissolve), the reaction temperature is maintained below -50°C during the dropping process. After dropping, stir and react at -65 ℃ for 3 hours. pour the reaction solution into a mixed solution of 35ml of concentrated ammonia water and 200ml of water, extract with 600ml of dichloromethane, dry with anhydrous magnesium sulfate, and concentrate under reduced pressure to obtain 2.06g of crude vincristine, and the purity is 83% detected by HPLC. the obtained crude vincristine is dissolved in 20ml of isopropanol, stirred, 16ml of 1% isopropanol sulfate solution is added dropwise to filter out the solid when the PH is adjusted to be ≤ 4, and is dried in vacuum to obtain 1.82g of crude vincristine sulfate. the purity is 92% detected by HPLC. dissolve 1.8g of crude vincristine sulfate in 36ml of absolute ethanol, cool to -10 ℃, stir slowly, precipitate solid, filter, wash with absolute ethanol, and dry in vacuum to obtain 1.63g of vincristine sulfate with 81.5% yield and 98.6% purity detected by HPLC.
use	sulfate of a natural alkaloid, isolated from plant vincristine, has anti-mitotic and anti-tumor activities. Vincristine irreversibly binds to microtubules and spindle proteins in the S phase of the cell cycle, interfering with the formation of mitotic spindles, thereby inhibiting tumor cells in the metaphase. The microtubules are depolymerized and may interfere with the metabolism of amino acids, cyclic adenosine monophosphate and glutathione. Natural plant anti-tumor drugs are used to treat acute leukemia and malignant lymphoma, small cell lung cancer and breast cancer. It is widely used in cancer research, multi-drug inhibition and monoamine oxidase (monoamine oxidase) inhibitor.

Product Packaging：

1) 1kg/bag (1kg net weight, 1.1kg gross weight, packed in an aluminum foil bag)

2) 25kg/drum (25kg net weight, 28kg gross weight; Packed in a cardboard-drum with two plastic-bags inside; Drum Size: 510mm high, 360mm diameter)

 Storage：

Stored in a cool and dry well-closed container. Keep away from moisture and strong light/heat.

Delivery：

Usually within3-5 working days after full payment.

transport：

EMS,DHL, TNT, UPS ,FEDEX, BY AIR, BY SEA

DHL Express, FedEx and EMS for quantity less than 50KG, usually called as DDU service; 

Sea shipping for quantity over 500KG; And air shipping is available for 50KG above;

For high value products, please select air shipping and DHL express for safe;

Our Service:
1. Fast Delivery: We can delivery within 24 hours upon receipt of your payment.
2. Quality can be promised. Hot sell to Worldwide.
3. Payment Terms: T/T,, t/t
4. Free Sample available at any time.
5. Tracking your order at any time. Inform your order's further new situation at any time.
6. Package: Professional packing with professional materials.

 

Packing:  
  1. Inner double plastic bags----25kg/Fiber drum (35*35*45cm, GW: 28kg, NW: 25kg); 

  2. Inner double plastic bags----5kg/Aluminum foil bag (GW: 6.5kg, NW: 5kg). 

  3. Inner double plastic bags----1kg/Aluminum foil bag (GW: 1.5kg, NW: 1kg). 

P.S.: we accept packaging customization. 

  
Delivery:   

  1. Stock products are normally shipping within 3 working days.  

  2. For rush delivery, please contact our sales team for particular arrangement. 

Shipping Details: 
  1. We ship goods via DHL, Fedex, UPS, TNT, China post, NL Post and other couriers, weight from 10g to 1000kg or even bulker. 

  2. Shipping details & shipping documents will be provided and sent by email. 

  3. We keep tracking the shippment until clients well received. 

  4. After years export shipping experience, with professional and experienced cooperated forwarders, we ensure that goods can be delivered in multiple ways safetly and efficiently. 

About us

Our company specializes in processing and selling chemical raw materials, chemical products, pharmaceutical intermediates, veterinary medicine intermediates, dye intermediates, pigments, cosmetics raw materials and chemical reagents,  

We have compalete sales and service team , information feedback vertical integration of a sound marketing network, products are sold throughout the country and exported to South Asia, Europe, America, Africa and other more than 20 countries and regions.  

Companies adhering to the "pursuit of quality, innovation and development" business philosophy, to serve as a foundation, for the survival by the quality, seek development by science and technology, adhere to quilty comes first,fair price,good sense of customer service and responsibility. in the future hebei Nengqian import and export trade Co.,Ltd will always hold "integrity, innovation" business philosophy, to achieve honesty management, on the way of specialization, internationalization,  Keep moving!  

 

FAQ: 
1. Are you a trade company or factory   
We are a  factory with our own trading company.  

2.How do you control the quality   
Our factory is equipped with professional technicians to control quality, out inspectors take sample for testing every 2 hours to ensure the quality of our production. We also accept BV, SGS or any other Third-party inspection.   

3. How long is lead time   
We deliver goods within 3 days for small order, 7-10 days for bulk order.   

4. Where is your factory located  How can I visit the factory   
 Our factory located in HEBEI, China.

5. Can i get some samples  
  Yes, we can supply free sample, but the shipping cost be paid by our customers. 

6. How to start orders or make payments  
  Proforma invoice will be sent first after confirmation of order, enclosed our bank information.Payment by T/T,  

7. How to confirm the Product Quality before placing orders  
  You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. 
  You can send us your product specifications and requests,we will manufacture the products according to your requests. 

8. How long is lead time

We deliver goods within 3 days for small order, 7-10 days for bulk order.

 

9. How do you treat quality complaint

  First of all, our quality control will reduce the quality problem to near zero. If there is a realquality problem caused by us, we will send you free goods for replacement or refund your loss.