Details:

Our advantage:

1. High quality with competitive price:

1) Standard:BP/USP/EP/Enterprise standard

2) All Purity≥99%

3) We are manufacturer and can provide high quality products with factory price.

 2, Fast and safe delivery

1) Parcel can be sent out in 24 hours after payment.Tracking number available

2) Secure and discreet shipment.Various transportation methods for your choice.

3) Customs pass rate ≥99%

4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe,

and we have stock in there for transferring.

Density	1.527±0.06 g/cm3(Predicted)
Melting Point	164-174°C
Boling Point	793.0±60.0 °C(Predicted)
Specific Rotation(α)	D20 +11° (c = 0.25 in acetone + alcohol)
Flash Point	274.4°C
Water Solubility	54mg/L(24.99 ºC)
Solubility	Easily soluble in acetone, ethyl acetate, methanol, ethanol, slightly soluble in chloroform, almost insoluble in water.
Vapor Presure	1.63E-26mmHg at 25°C
Appearance	White-like crystalline powder
Color	Pale Yellow
Merck	13,8607
pKa	pKa 6.42±0.04 (Uncertain)
Storage Condition	-20°C
Stability	Stable. Incompatible with strong oxidizing agents, strong bases.
Refractive Index	1.684
MDL	MFCD03225424
Physical and Chemical Properties
Use	Has obvious liver protection effect, suitable for acute and chronic hepatitis, early cirrhosis, etc
In vitro study	Silibinin is A mixture of two enantiomers of silibinin A and silybinin B in approximately equimolar ratio. Both in vitro and animal studies have shown that silibinin has a hepatoprotective effect (anti-hepatotoxicity) and protects liver cells from toxic damage. In in vitro assays, Silibinin has anticancer effects on human prostate cancer cells, estrogen-dependent and non-dependent human breast cancer cells, human cervical cancer cells, human colon cancer cells, small and non-small human lung cancer cells.

 

Preparation Method

Open Data Verified Data

general silymarin seeds as raw material extraction. Take 5kg silymarin seed crushing, with petroleum ether (30~60 ℃) defatted for 24h, defatted powder volatilized to petroleum ether after 60 mesh sieve, then with acetone reflux extraction for 32H, concentrate the Acetone Extract to a certain volume
After upper silica gel column, with chloroform: ethanol (95:5) elution, and identified by thin layer chromatography collected components, the same spots combined, reduced pressure concentration to dry, the main spots can be obtained light yellow crystals, with a small amount of methanol wash 2 times, after drying to obtain silymarin crude crystal 22.5g, the yield is 0. 45%. The crude crystals were soaked with a small amount of acetone, stirred and allowed to stand for 2 days, and the acetone solution was filtered to obtain a white powder, which was dried. A sample of the dried white powder was taken. 200ml of distilled water was added to 5G, the pH value was adjusted to 9 to 10 with 1 mol/L NaOH solution, and the whole was dissolved by slight heating. Then, 500ml of chloroform was added, and the chloroform layer was separated by shaking. The chloroform layer solution was concentrated to dryness under reduced pressure to give a white powder. Dissolve the white powder with acetone, filter, concentrate the acetone to a certain volume, add petroleum ether (60~90 ℃) to slightly turbid, and place overnight to obtain crystallization. According to this step, the product was crystallized twice with acetone petroleum ether and dried in a vacuum drying oven to obtain pure silymarin.

Reference Information

plant source:	milk thistle
Silybum marianum extract	Silybin is a flavonoid lignan compound isolated from the seeds of the Compositae plant Purple Silybum marianum. The main active ingredients are Silybin, isosybinin, Silybum marianum and Silyphine, which can prevent damage to the liver caused by chemical toxins, food toxins and drugs, and promote the regeneration and repair of liver cells, it is called "natural hepatoprotective medicine". White crystalline powder at room temperature, odorless, slightly bitter taste, hygroscopic, soluble in acetone, ethyl acetate, methanol, ethanol, slightly soluble in chloroform, almost insoluble in water. Silibinin is also known as heparin, milk thistle, milk thistle, milk thistle total flavonoids, silimaling, yiganling, silymarin, ligalon, as early as 2000 years ago, the ancient Chinese used milk thistle to treat liver and gallbladder diseases, clinical shows that it has obvious protection and stability of liver cell membrane; it has different degrees of protective and therapeutic effects on various types of liver injury caused by liver poisons such as carbon tetrachloride, thioacetamide, muscarinic, phalloidin, and has a certain preventive effect on the increase of alanine aminotransferase caused by carbon tetrachloride. It is suitable for the treatment of chronic persistent hepatitis, chronic active hepatitis, initial cirrhosis, liver poisoning and other diseases. In addition, this product also has strong antioxidant properties, can remove free radicals in the human body, delay aging, and has been widely used in medicine, health products, food and cosmetics and other fields.
biological activity	Silibinin (Silybin, Silibinin A, Silymarin I) is the main active ingredient of Silymarin.
use	has obvious liver protection effect and is suitable for acute and chronic hepatitis, early liver cirrhosis, etc. silibinin is a mixture of two enantiomers of AB with an approximate equimolar ratio.

 

Product Packaging：

1) 1kg/bag (1kg net weight, 1.1kg gross weight, packed in an aluminum foil bag)

2) 25kg/drum (25kg net weight, 28kg gross weight; Packed in a cardboard-drum with two plastic-bags inside; Drum Size: 510mm high, 360mm diameter)

 Storage：

Stored in a cool and dry well-closed container. Keep away from moisture and strong light/heat.

Delivery：

Usually within3-5 working days after full payment.

transport：

EMS,DHL, TNT, UPS ,FEDEX, BY AIR, BY SEA

DHL Express, FedEx and EMS for quantity less than 50KG, usually called as DDU service; 

Sea shipping for quantity over 500KG; And air shipping is available for 50KG above;

For high value products, please select air shipping and DHL express for safe;

Our Service:
1. Fast Delivery: We can delivery within 24 hours upon receipt of your payment.
2. Quality can be promised. Hot sell to Worldwide.
3. Payment Terms: T/T,, t/t
4. Free Sample available at any time.
5. Tracking your order at any time. Inform your order's further new situation at any time.
6. Package: Professional packing with professional materials.

 

Packing:  
  1. Inner double plastic bags----25kg/Fiber drum (35*35*45cm, GW: 28kg, NW: 25kg); 

  2. Inner double plastic bags----5kg/Aluminum foil bag (GW: 6.5kg, NW: 5kg). 

  3. Inner double plastic bags----1kg/Aluminum foil bag (GW: 1.5kg, NW: 1kg). 

P.S.: we accept packaging customization. 

  
Delivery:   

  1. Stock products are normally shipping within 3 working days.  

  2. For rush delivery, please contact our sales team for particular arrangement. 

Shipping Details: 
  1. We ship goods via DHL, Fedex, UPS, TNT, China post, NL Post and other couriers, weight from 10g to 1000kg or even bulker. 

  2. Shipping details & shipping documents will be provided and sent by email. 

  3. We keep tracking the shippment until clients well received. 

  4. After years export shipping experience, with professional and experienced cooperated forwarders, we ensure that goods can be delivered in multiple ways safetly and efficiently. 

About us

Our company specializes in processing and selling chemical raw materials, chemical products, pharmaceutical intermediates, veterinary medicine intermediates, dye intermediates, pigments, cosmetics raw materials and chemical reagents,  

We have compalete sales and service team , information feedback vertical integration of a sound marketing network, products are sold throughout the country and exported to South Asia, Europe, America, Africa and other more than 20 countries and regions.  

Companies adhering to the "pursuit of quality, innovation and development" business philosophy, to serve as a foundation, for the survival by the quality, seek development by science and technology, adhere to quilty comes first,fair price,good sense of customer service and responsibility. in the future hebei Nengqian import and export trade Co.,Ltd will always hold "integrity, innovation" business philosophy, to achieve honesty management, on the way of specialization, internationalization,  Keep moving!  

 

FAQ: 
1. Are you a trade company or factory   
We are a  factory with our own trading company.  

2.How do you control the quality   
Our factory is equipped with professional technicians to control quality, out inspectors take sample for testing every 2 hours to ensure the quality of our production. We also accept BV, SGS or any other Third-party inspection.   

3. How long is lead time   
We deliver goods within 3 days for small order, 7-10 days for bulk order.   

4. Where is your factory located  How can I visit the factory   
 Our factory located in HEBEI, China.

5. Can i get some samples  
  Yes, we can supply free sample, but the shipping cost be paid by our customers. 

6. How to start orders or make payments  
  Proforma invoice will be sent first after confirmation of order, enclosed our bank information.Payment by T/T,  

7. How to confirm the Product Quality before placing orders  
  You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. 
  You can send us your product specifications and requests,we will manufacture the products according to your requests. 

8. How long is lead time

We deliver goods within 3 days for small order, 7-10 days for bulk order.

 

9. How do you treat quality complaint

  First of all, our quality control will reduce the quality problem to near zero. If there is a realquality problem caused by us, we will send you free goods for replacement or refund your loss.