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1. High quality with competitive price:

1) Standard:BP/USP/EP/Enterprise standard

2) All Purity≥99%

3) We are manufacturer and can provide high quality products with factory price.

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1) Parcel can be sent out in 24 hours after payment.Tracking number available

2) Secure and discreet shipment.Various transportation methods for your choice.

3) Customs pass rate ≥99%

4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe,

and we have stock in there for transferring.

Specific Rotation(α)	26.5 º (c=5, in water)
Flash Point	145 °C
Water Solubility	Soluble in water.
Solubility	Soluble in water, glycerol and alkali solution, slightly soluble in ethanol and acetone, insoluble in benzene
Appearance	White lens powder
Color	White or almost white
Merck	14,7015
BRN	3769272
PH	6.8-7.2 (25℃, 50mg/mL in H2O)
Storage Condition	2-8°C
Stability	Stable, but may be moisture or air sensitive. Incompatible with strong acids, strong bases.
Sensitive	Hygroscopic
Refractive Index	27 ° (C=5, H2O)
MDL	MFCD00002766
Physical and Chemical Properties	Melting point 190°C specific rotation 26.5 ° (c = 5, in water)
Use	Feed additives, food additives, in accordance with the Pharmacopoeia USP28/BP2003

Introduction

This product is a precursor of coenzyme A synthesis and is used to prepare tissue culture medium. Biochemical research. Nutrients. Calcium D-Panthotenate, also known as vitamin B5 Calcium, is a water-soluble vitamin and an essential nutrient for many animals. Since the free acid is unstable and hygroscopic, it takes the form of calcium salt. Can reduce patulin in apple juice. & & Biological activity: & & In vitro study: In human lymphocytes (Jurkat cells), Pantothenic acid increases free glutathione and has little effect on protein-bound glutathione. Pantothenic acid also increases cell respiration, with pyruvate as an exogenous substrate. Pantothenic acid belongs to the vitamin B family and is a component of coenzyme A. Pantothenic acid participates in various cellular damages of reactive oxygen species by increasing the amount of coenzyme A. Pantothenic acid increased the content of glutathione by more than 50% and increased the GSH / GSSG ratio by 50%. Pantothenic acid and N-acetylcysteine attenuated UV-induced reductions in glutathione content, reduced lipid peroxidation, and partially protected cells from apoptosis caused by UV irradiation. & & In vivo study: In the adrenal cells of control rats, pantothenic acid-treated rats showed relatively high basal levels of corticosterone and progesterone. Pantothenic acid supplementation stimulates the ability of male rats to secrete corticosterone and progesterone in adrenal cells. Pantothenic acid supplementation induces adrenalhyperresponsiveness to ACTH stimulation and PRL to further stimulate adrenal sensitivity ACTH. In CD-1 mice, valproic acid (VPA) before pantothenic acid significantly prevents VPA-induced neural tube defects (NTDs). Pantothenic acid prevents valproic acid-induced changes in NF-κB,PIM-1 and c-Myb.

identification

1. take an appropriate amount of fine powder of this product (about 50mg equivalent to calcium pantothenate), add 5ml of sodium hydroxide solution, shake, filter, add 1 drop of copper sulfate solution to the filtrate, which shows dark blue.
2. take an appropriate amount of fine powder of this product (about 50mg of calcium pantothenate), add 5ml of sodium hydroxide solution, boil for 1 minute, let it cool, add 5ml of lmol/L hydrochloric acid solution, and add 2 drops of ferric chloride solution, that is yellow.
3. take an appropriate amount of fine powder of this product, add water to shake, filter, and the filtrate shows the identification reaction of calcium salt (General rule 0301).

examination

• Content uniformity take 1 tablet of this product, put it in a 10ml(5mg specification) or 20ml(10mg specification) measuring flask, add an appropriate amount of mobile phase, ultrasonic to dissolve calcium pantothenate, and let it cool, dilute to scale with mobile phase, shake well, centrifuge, take the supernatant and determine the content according to the method under the content determination item, which should comply with the regulations (General rule 0941).
• the dissolution of this product, according to the dissolution and release determination method (General rule 0931 second method), water 900ml as the dissolution medium, the speed of 50 rpm, according to the law, after 45 minutes, the solution was filtered, and the continued filtrate was taken as the test solution; Another calcium pantothenate reference substance was taken, and the precise weighing was performed, water was added to dissolve and quantitatively diluted to prepare a solution containing about 5.6ug(5mg specification) or 11 lug (10 mg specification) per 1 ml as a control solution. According to the method under the content determination item, the dissolution amount of each tablet was calculated by the peak area according to the external standard method. The limit is 75% of the labeled amount and shall be in accordance with the provisions.
• others shall be in accordance with the relevant provisions under the item of tablets (General rule 0101).

Content determination

• measured by high performance liquid chromatography (General 0512).
• chromatographic conditions and system suitability test using eighteen alkyl silane bonded silica gel as filler; Acetonitrile-water-phosphoric acid (50:950:1) as mobile phase; The detection wavelength was 210nm. The degree of separation between the calcium pantothenate peak and the adjacent impurity peak shall meet the requirements.
• determination Method: Take 20 tablets of this product, accurately weigh, grind, accurately weigh an appropriate amount (about 25mg equivalent to calcium pantothenate), put it in a 50ml measuring flask, add an appropriate amount of mobile phase, and ultrasonic to dissolve calcium pantothenate, cool, dilute to the scale with mobile phase, shake well, centrifuge, and accurately take 10ul of the liquid to be injected into the human liquid chromatograph, record the chromatogram; Take another calcium pantothenate reference substance, and accurately weigh it, the mobile phase was added to dissolve and quantitatively dilute to make a solution containing 0.5mg per 1 ml, which was determined by the same method. According to the external standard method to calculate the peak area, that is.

introduction	calcium pantothenate is a kind of B vitamins and one of the essential nutrients for normal growth of organisms. Calcium pantothenate exists in three forms due to its chiral carbon atom: D L-body (mixed spin), D-body (right-handed body) and L-body (left-handed body). Only D-calcium pantothenate has biological activity. Its appearance is white or yellowish needle-like crystal or powder, its melting point is 195~196 ℃ (decomposition), and it is soluble in water, methanol, glycerin, slightly soluble in ethanol and acetone, it is hygroscopic and slightly sweet, but turns slightly bitter. As far as chemical stability is concerned, it is the most stable in aqueous solution with pH value between 5 and 7, which is more stable in air and sunlight, but less stable in acid and alkali.
deficiency	lack of calcium pantothenate in human body has the following symptoms:(1) growth arrest, weight loss and sudden death. (2) Skin and hair disorders. (3) Nervous system disorders. (4) digestive organ disorders, liver dysfunction. (5) Affect antibody formation. (6) Parabenal disorders. Each person needs about 5mg per day (calcium pantothenate juice).
pharmacological action	pantothenic acid is the precursor of coenzyme a and is a substance necessary for various metabolic links (including carbohydrates, proteins and lipids). it can participate in the synthesis of steroids, porphyrins, acetylcholine and other substances, and can maintain normal epithelial function.
application	D-calcium pantothenate can be used as a nutritional supplement. Except for special nutritious foods, the usage must be less than 1% (calculated as calcium) (Japanese standard). When milk powder is fortified, it is 10mg/100g. Add 0.02% to shochu and whisky to enhance flavor. 0.02% added to honey can prevent winter crystallization. It can buffer the bitter taste of caffeine and saccharin.
preparation method	D-calcium pantothenate can be formed by aldol condensation of isobutyraldehyde and formaldehyde in the presence of potassium carbonate, then cyanidation and lactone into dl-pantoacolactone, and then reaction with calcium aminopropionate.
precautions	precautions for the use of D-calcium pantothenate: 1) pantothenic acid requirement increases when suffering from malabsorption syndrome caused by tropical stomatitis diarrhea, celiac disease or localized enteritis. 2) Patients with hemophilia should be cautious when taking medicine, because pantothenic acid can prolong the bleeding time.
store	storage of D-calcium pantothenate: store in a cool and dry place.
toxicity	LD50>10 g/kg (rat, oral). GRAS(FDA,§ 182.5212,§ 184.1212,2000).
use limit	GMP is limited (FDA 184.1212,2000). General food 1% (in terms of calcium, except for special nutrients; Japan, 1993).
use	biochemical research; Nutritional components of tissue culture medium. It is clinically used to treat vitamin B deficiency, peripheral neuritis and intestinal colic after surgery. As a food fortifier. Can be used for infant food, the usage amount is 15~28mg/kg; In the drink liquid is 2~4mg/kg. This product is a vitamin drug and is a component of coenzyme A. In the mixed calcium pantothenate, only the right-handed body has vitamin activity and participates in the metabolism of protein, fat and sugar in the body. It is used for vitamin B deficiency and peripheral neuritis, as well as intestinal colic after surgery. Combined with vitamin C can treat disseminated lupus erythematosus. The lack of calcium pantothenate in the human body has the following symptoms:(1) growth stops, weight loss, and sudden death. (2) Skin and hair disorders. (3) Nervous system disorders. (4) digestive organ disorders, liver dysfunction. (5) Affect antibody formation. (6) Parabenal disorders. The human body needs about 5mg of calcium pantothenate (based on pantothenic acid) every day. Calcium pantothenate is used as a nutritional supplement for food processing. Except for special nutritious foods, the usage must be less than 1% (calculated as calcium) (Japan). When milk powder is fortified, it is 10mg/100g. Add 0.02% to shochu and whisky to enhance flavor. 0.02% added to honey can prevent winter crystallization. It can buffer the bitter taste of caffeine and saccharin. Feed additives, food additives, in accordance with Pharmacopoeia USP28/BP2003 Nutritional supplements. It can enhance the flavor of shochu whisky and prevent honey from crystallization in winter. the premise of biosynthesis of coenzyme a, due to the easy deliquescence of pantothenic acid and other unstable characteristics, calcium salt is used as a substitute.
production method	is obtained from isobutyraldehyde by formaldehyde hydroxymethylation, addition, hydrolysis, acidification, internal esterification, acylation and addition. put formaldehyde and anhydrous potassium carbonate into the reaction pot, add isobutyraldehyde dropwise at 14~20 ℃, keep warm and stir for 3 hours after adding; Then let stand for 0.5h at 14~18 ℃ to obtain the upper oil 2,2-dimethyl -3-hydroxypropanal. Dissolve 2, 2-dimethyl-3-hydroxypropanal in 4 times of water, dissolve sodium cyanide in 6 times of water, dissolve calcium chloride in 2 times of water, and add the above solution to the reaction pot in turn; Add 50% sulfuric acid solution under stirring, react at 60~65 ℃ for 6h, and then raise the temperature to 80~85 ℃ for 3h; Concentrate under reduced pressure until thick, add 95% ethanol to precipitate and filter inorganic salts. After the filtrate is distilled under reduced pressure to recover ethanol, the fraction at 130~145 ℃(1.33~2.39kPa), namely γ-butyrolactone, is collected. Add β-aminopropionic acid, 5/6 methanol and lime to the reactor in turn, raise the temperature to 40 ℃, and stir for reaction for 2h; After the reaction liquid is standing, the supernatant liquid is pressed and filtered, and the solid residue in the pot is washed with 1/6 methanol and then pressed and filtered. The filtrate is placed in another reaction pot, γ-butyrolactone is added, stirred and dissolved, and reacted at room temperature for 40h to generate calcium pantothenate. Add water, stir, cool to O ~-5 ℃, add seed crystal, stir and crystallize for 24 hours, and filter to obtain racemic calcium pantothenate. Put 2/3 amounts of racemic calcium pantothenate and levopantothenate into the reaction pot, add methanol and water to heat to 40 ℃, stir and dissolve, and filter while hot, cool the filtrate to 15 ℃, add a small amount of levothenate calcium seed, and cultivate the crystal for 2 hours; when the specific rotation reaches 6 ° ~ 8 °, separate and crystallize, and wash with a small amount of methanol to obtain levopantothenate calcium (still used for resolution); the remaining 1/3 of the racemic calcium pantothenate was stirred and dissolved in the filtrate at 35~40 ℃, filtered and cooled to 15 ℃, a small amount of calcium pantothenate crystal was added, and the crystal was cultivated for 2 hours. When the specific rotation is -0.6 ~-0.8. Crystallization is separated, washed with a small amount of methanol and dried in vacuum to obtain calcium dextran. Calcium β-aminopropionate and α-hydroxy β,β-dimethyl-γ-butyl propyl ester are prepared by heating condensation. using isobutyraldehyde and the like as raw materials, obtained by hydroxymethylation, addition, hydrolysis, acidification, internal esterification and acylation, formaldehyde and anhydrous potassium carbonate are put into a reaction pot, isobutyraldehyde is added dropwise at 14-20 ℃, heated and stirred for 3 hours after adding, and then let stand for 0.5h at 14-18 ℃ to obtain the upper oil 2,2-dimethyl -3-hydroxypropanal. Dissolve 2, 2-dimethyl-3-hydroxypropanal in 4 times of water, dissolve sodium cyanide in 6 times of water, dissolve calcium clovarite in 2 times of water, and add the above solution to the reaction pot in turn, Add 50% sulfuric acid solution under stirring, react at 60-65 ℃ for 6h, then raise the temperature to 80-85 ℃ for 3h, and concentrate under reduced pressure until thick, 95% ethanol was added to precipitate and filter the inorganic salt. After the filtrate was distilled under reduced pressure to recover ethanol, the 130-145 ℃(1.33-2.39Kpa) fraction, namely γ-butyrolactone, was collected. β-aminopropionic acid, 5/6 methanol and lime were sequentially added to the reactor, the temperature was raised to 40 ℃, and the reaction was stirred for 2 hours. After the reaction liquid is left standing, the supernatant liquid is pressed and filtered. The solid residue in the pot is washed with 1/6 methanol and then filtered by pressure. The filtrate is placed in another reaction pot, added with γ-butyrolactone, stirred and dissolved, and placed at room temperature for 40h to react to produce calcium pantothenate. Add water, stir, cool to -5-0 ℃, add seed crystal, stir and crystallize for 24 hours, and filter to obtain racemic calcium pantothenate. Put 2/3 amount of racemic calcium pantothenate and levopantothenate into the reaction pot, add methanol and water, heat to 40 ℃, stir and dissolve, filter while hot, cool the filtrate to 15 ℃, add a small amount of levothenate calcium seed, and cultivate the crystal for 2 hours. When the specific rotation reaches 6 ° -8 °, the crystallization is separated and washed with a small amount of methanol to obtain calcium levopantothenate (still used for resolution). The remaining 1/3 of the racemic calcium pantothenate was stirred and dissolved in the filtrate at 35-40 ℃, filtered and cooled to 15 ℃, a small amount of calcium pantothenate seed was added, and the crystal was cultivated for 2 hours. Crystallization is separated when the specific rotation is -0.8 ° -0.6 °, washed with a small amount of methanol, and dried in vacuum to obtain calcium dexpantothenate.
category	toxic substances
toxicity classification	low toxicity
acute toxicity	oral-rat LD50: 10000 mg/kg; Oral-mouse LD50: 10000 mg/kg
flammability hazard characteristics	thermal decomposition discharges toxic nitrogen oxide smoke
storage and transportation characteristics	warehouse low temperature ventilation and drying
fire extinguishing agent	water, carbon dioxide, dry powder, foam

Product Packaging：

1) 1kg/bag (1kg net weight, 1.1kg gross weight, packed in an aluminum foil bag)

2) 25kg/drum (25kg net weight, 28kg gross weight; Packed in a cardboard-drum with two plastic-bags inside; Drum Size: 510mm high, 360mm diameter)

 Storage：

Stored in a cool and dry well-closed container. Keep away from moisture and strong light/heat.

Delivery：

Usually within3-5 working days after full payment.

transport：

EMS,DHL, TNT, UPS ,FEDEX, BY AIR, BY SEA

DHL Express, FedEx and EMS for quantity less than 50KG, usually called as DDU service; 

Sea shipping for quantity over 500KG; And air shipping is available for 50KG above;

For high value products, please select air shipping and DHL express for safe;

Our Service:
1. Fast Delivery: We can delivery within 24 hours upon receipt of your payment.
2. Quality can be promised. Hot sell to Worldwide.
3. Payment Terms: T/T,, t/t
4. Free Sample available at any time.
5. Tracking your order at any time. Inform your order's further new situation at any time.
6. Package: Professional packing with professional materials.

 

Packing:  
  1. Inner double plastic bags----25kg/Fiber drum (35*35*45cm, GW: 28kg, NW: 25kg); 

  2. Inner double plastic bags----5kg/Aluminum foil bag (GW: 6.5kg, NW: 5kg). 

  3. Inner double plastic bags----1kg/Aluminum foil bag (GW: 1.5kg, NW: 1kg). 

P.S.: we accept packaging customization. 

  
Delivery:   

  1. Stock products are normally shipping within 3 working days.  

  2. For rush delivery, please contact our sales team for particular arrangement. 

Shipping Details: 
  1. We ship goods via DHL, Fedex, UPS, TNT, China post, NL Post and other couriers, weight from 10g to 1000kg or even bulker. 

  2. Shipping details & shipping documents will be provided and sent by email. 

  3. We keep tracking the shippment until clients well received. 

  4. After years export shipping experience, with professional and experienced cooperated forwarders, we ensure that goods can be delivered in multiple ways safetly and efficiently. 

About us

Our company specializes in processing and selling chemical raw materials, chemical products, pharmaceutical intermediates, veterinary medicine intermediates, dye intermediates, pigments, cosmetics raw materials and chemical reagents,  

We have compalete sales and service team , information feedback vertical integration of a sound marketing network, products are sold throughout the country and exported to South Asia, Europe, America, Africa and other more than 20 countries and regions.  

Companies adhering to the "pursuit of quality, innovation and development" business philosophy, to serve as a foundation, for the survival by the quality, seek development by science and technology, adhere to quilty comes first,fair price,good sense of customer service and responsibility. in the future hebei Nengqian import and export trade Co.,Ltd will always hold "integrity, innovation" business philosophy, to achieve honesty management, on the way of specialization, internationalization,  Keep moving!  

 

FAQ: 
1. Are you a trade company or factory   
We are a  factory with our own trading company.  

2.How do you control the quality   
Our factory is equipped with professional technicians to control quality, out inspectors take sample for testing every 2 hours to ensure the quality of our production. We also accept BV, SGS or any other Third-party inspection.   

3. How long is lead time   
We deliver goods within 3 days for small order, 7-10 days for bulk order.   

4. Where is your factory located  How can I visit the factory   
 Our factory located in HEBEI, China.

5. Can i get some samples  
  Yes, we can supply free sample, but the shipping cost be paid by our customers. 

6. How to start orders or make payments  
  Proforma invoice will be sent first after confirmation of order, enclosed our bank information.Payment by T/T,  

7. How to confirm the Product Quality before placing orders  
  You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. 
  You can send us your product specifications and requests,we will manufacture the products according to your requests. 

8. How long is lead time

We deliver goods within 3 days for small order, 7-10 days for bulk order.

 

9. How do you treat quality complaint

  First of all, our quality control will reduce the quality problem to near zero. If there is a realquality problem caused by us, we will send you free goods for replacement or refund your loss.