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Product Description:

Introduction	High-purity arachidonic acid is the synthesis of prostaglandin (prostaglandins), thromboxane (thromboxanes) and leukotriene (leukotrienes) The direct precursor of carbon derivatives, these biologically active substances play a very important role in the human cardiovascular system and immune system.
Unsaturated fatty acid	Arachidonic acid, referred to as ARA. It is an omega-6 polyunsaturated fatty acid that is commonly found in our foods, such as beef, chicken, eggs, or fish. Generally speaking, we can consume 100-200 mg of arachidonic acid per day. Arachidonic acid is one of the most active omega-6 fatty acids. It plays an important role in the development of the nervous system, the maintenance of immunity, the development of memory/learning ability, the maintenance of bone mineral density, the health of pancreatic islets, and the health of the heart and blood system. Arachidonic acid is common in land animal fats such as pig fat and tallow, but the content is not high, generally less than 1%; it is rare in vegetable oils, only found in moss and fern seed oil There are trace amounts; it mainly exists in marine fish oil. Studies have found that the content of arachidonic acid in adrenal phospholipid fatty acids in land animals (pigs, cattle) is as high as more than 15%. Industry mainly uses microbial fermentation to produce AA, which is an important precursor for human body to synthesize prostaglandins.
traits	white to light yellow powder.
efficacy and action	1. regulation of cardiac excitability latest research reports that arachidonic acid and its metabolites such as LTC4 can activate the toxicosine-like K channel coupled to the heart and G protein in a receptor-independent manner, and regulate cardiac excitability under physiological and pathological conditions. 2. involved in neuroendocrine arachidonic acid can stimulate the secretion of anterior pituitary, placenta and mast cells, and participate in regulating the secretion of various hormones and neuropeptides in various neuroendocrine tissues, such as oxytocin, vasopressin, insulin and glucagon. 3. promoting cell division arachidonic acid and its metabolites can promote cell division, and its metabolites have this effect in smooth muscle cells, fibroblasts and lymphocytes. 4. inhibition of platelet aggregation arachidonic acid and its metabolites can cause vasodilation. Vascular endothelial cells are closely related to arachidonic acid enzyme, which can release vasodilator, relax vascular smooth muscle and relax blood vessels under certain stimulation. due to the above physiological functions, arachidonic acid is widely used in cosmetics, medicine, food and other fields.
use	nutritional additives. Valium, anti-peptic ulcer and gastrointestinal dysfunction, acts on the uterus. Arachidonic acid is an important substance in the development of human brain and optic nerve, and plays an important role in improving intelligence and enhancing visual acuity. Arachidonic acid has a series of physiological activities such as esterifying cholesterol, increasing vascular elasticity, reducing blood viscosity, and regulating blood cell function. Arachidonic acid has important effects on the prevention of cardiovascular diseases, diabetes and tumors. Raw materials for the synthesis of prostaglandins. Regulates the permeability of human cell membranes. It is very important for the brain and nerve development of infants and young children, and the development of the optic nervous system. It also plays an important role in the treatment of coronary heart disease, diabetes and the prevention of cerebrovascular diseases. Nutritional fortifier.
consumption	≤ 600 mg/day (calculated as pure arachidonic acid)
approval date	2010-03-09
Announcement No.	No. 3 of 2010
announcement title	announcement on approving 7 items such as DHA algae oil and cottonseed oligosaccharides as new resource foods and other relevant regulations
Character	Colorless to light yellow oily liquid
arachidonic acid content	≥38g/100g
Trans fatty acid	≤1%
usage limit	FAO/WHO: infant 60rag/(kg body weight d). GB 2760 2002: infant formula 1.6~2.6 g/kg. Infant formula milk powder 0.09% ~ 0.15% [percentage of fatty acids; refers to arachidonic acid single cell oil (ARASCO)].
production method	mycelium obtained by fermentation and culture of Mortierella alpina, about 3% of dry bacteria are obtained after filtration and squeezing, and about 20% of oil containing AA and unsaturated fatty acids such as α-linolenic acid and γ-linolenic acid are obtained after supercritical extraction with CO2. method preparation of oil ether solution by 1. bromination debromination method 40kg of minced pig adrenal gland was weighed, equal volume of 95% ethanol and 2.5kg of potassium hydroxide was added, pH10 was adjusted, stirred evenly, heated and refluxed with nitrogen until saponification was complete, and saponified solution was obtained. Cool the saponified liquid to 50 ℃, add equal volume of hydrochloric acid, adjust pH3, delaminate, extract the emulsified layer with ether, combine the ether extract and oil layer, concentrate to half, place in -20 ℃ cold storage overnight, filter at 0 ℃, wash the filter residue with ether, combine the filtrate, concentrate to half, and then place in -20 ℃ cold storage overnight. Such repeated treatment results in oil ether solution. Preparation of debromination solution of porcine adrenal gland [ethanol] →[KOH, pH10] saponification solution [HCl, pH3]→ [ether] oil ether solution: add bromine ether solution (prepared below 0 ℃, V bromine: V ether = 1:2) into oil ether solution, stir vigorously while adding, until bromination is complete, orange precipitate is precipitated, and the bromine ether solution is dumped, the precipitate is washed with ether until the washing liquid is colorless, the precipitate is white, and it is dried to obtain bromide. Grinding bromide finely, adding 100g of bromide to 100g of zinc powder, 750-1000ml of methanol and 2-4ml of hydrochloric acid, refluxing with nitrogen in a 75-80 ℃ water bath for 8h, filtering, washing the filter residue with appropriate amount of methanol, combining filtrate and washing solution to obtain debromination solution. Preparation of oil ether solution [bromine, diethyl ether] →[<0 ℃] bromide [zinc, methanol] →[8h] debromination solution methyl arachidonic acid; concentrate the debromination solution to 1/3 volume, add 3 times the amount of water, add 4mol/L hydrochloric acid to adjust pH3, add diethyl ether for extraction for 3-4 times, combine diethyl ether extract, add anhydrous sodium sulfate, add nitrogen filling and concentrate to remove diethyl ether to obtain crude oil. Add 2-3 times methanol (containing saturated hydrogen chloride) and return to water bath at 70-80 ℃ for 6 hours. Add 2mol/L sodium hydroxide to adjust the pH5-6, filter, wash the precipitation with ether, combine the filtrate, concentrate to remove the organic solvent, obtain the methyl ester liquid, and then carry out high vacuum distillation, take the 190-200 ℃ fraction to obtain the arachidonic acid methyl ester. Debromination solution [diethyl ether] →[Na2SO4,pH3] refined oil [methanol] →[70-80 ℃, 6h] methyl ester solution [190-200 ℃,0.3kPa]→ preparation of arachidonic acid methyl ester arachidonic acid finished product take arachidonic acid methyl ester, add 10 times the amount of 1mol/L KOH methanol solution, add nitrogen and reflux at 40-80 ℃ for 0.5h, concentrate to remove part of methanol, add 3 times the amount of water, add 4mol/L hydrochloric acid to adjust pH 3. Add ether for extraction, add water to the ether layer to wash until pH5-6, add anhydrous sodium sulfate, add nitrogen and concentrate under reduced pressure to remove ether to obtain arachidonic acid finished product. Arachidonic acid methyl ester [ether] →[KOH, 40-80 ℃, 0.5h] arachidonic acid finished product method preparation of mixed fatty acid ether solution 2. urea inclusion method pig adrenal gland homogenate is taken, 95% ethanol (3 times, 2 times) is added to extract twice, filtered to obtain filtrate, concentrate to remove ethanol, add ether for extraction, concentrate to remove ether, and obtain lipids. Add 1.5 times ethanol to dissolve, add 500g/L potassium hydroxide to adjust pH10 or more, and refluxed with nitrogen to obtain mixed fatty acid potassium salt. Add acid to adjust pH3, add ether to extract, get mixed fatty acid ether solution. Preparation of pig adrenal homogenate [ethanol, ether] →[KOH, HCl, pH10, pH3] mixed fatty acid ether solution mixed unsaturated fatty acid The mixed fatty acid ether solution is concentrated to remove the ether, and 10 times the amount of acetone is added to dissolve it. Freeze and crystallize at -5 ℃, -25 ℃, -45 ℃, -72 ℃, 2h each time, filter, and concentrate the filtrate to remove acetone to obtain mixed unsaturated fatty acid. Mixed fatty acid ether solution [acetone, 2h]→[-5 ℃, -25 ℃, -45 ℃, -72 ℃] Preparation of mixed unsaturated fatty acid arachidonic acid finished product Dissolve the mixed unsaturated fatty acid with appropriate amount of methanol, add urea and methanol, after the urea is dissolved, freeze and crystallize at -3 ℃, -20 ℃, -75 ℃, filter, add anhydrous sodium sulfate to dry, steam to remove methanol to obtain arachidonic acid. Mixed unsaturated fatty acids [urea, methanol, anhydrous sodium sulfate] →[-3 ℃, -20 ℃, -75 ℃] arachidonic acid finished product method 3. preparation of linoleic acid using oleic acid as raw material using oleic acid as raw material, after desaturation, linoleic acid is prepared. Oleic acid [desaturation] → Preparation of linoleic acid Linoleic acid produces α-linolenic acid under the action of ω-3 dehydrogenase; γ-linolenic acid is produced under the action of ω-6 dehydrogenase. Preparation of arachidonic acid α-linolenic acid is grown by C2 chain to obtain eicosatrienoic acid. Eicosatrienoic acid is desaturated to produce arachidonic acid. α-linolenic acid [C2 chain growth] → eicosatrienoic acid [desaturation] → arachidonic acid method 4. microbial fermentation method The Ion Beam Bioengineering Center of the Institute of Plasma Physics, Chinese Academy of Sciences uses my country's first ion beam mutagenesis technology to inject and improve AA starting bacteria NT, and successfully screened a high-yield bacteria bead. Shinmen, etc. used the beads of Mortierella alpine and Mortierella to ferment AA, and screened the high-yield strains of AA.
category	toxic substances
toxicity classification	highly toxic
acute toxicity	intravenous-rat LDL0: 100 mg/kg; Intravenous-mouse LD50: 33 mg/kg
flammability hazard characteristics	combustible; combustion produces stimulating smoke
storage and transportation characteristics	warehouse ventilation and low temperature drying; separate from food raw materials
fire extinguishing agent	dry powder, foam, sand, carbon dioxide, mist water

 

Our advantage:

1. High quality with competitive price:

1) Standard:BP/USP/EP/Enterprise standard

2) All Purity≥99%

3) We are manufacturer and can provide high quality products with factory price.

 2, Fast and safe delivery

1) Parcel can be sent out in 24 hours after payment.Tracking number available

2) Secure and discreet shipment.Various transportation methods for your choice.

3) Customs pass rate ≥99%

4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe,

and we have stock in there for transferring.

Product Packaging：

1) 1kg/bag (1kg net weight, 1.1kg gross weight, packed in an aluminum foil bag)

2) 25kg/drum (25kg net weight, 28kg gross weight; Packed in a cardboard-drum with two plastic-bags inside; Drum Size: 510mm high, 360mm diameter)

 Storage：

Stored in a cool and dry well-closed container. Keep away from moisture and strong light/heat.

Delivery：

Usually within3-5 working days after full payment.

transport：

EMS,DHL, TNT, UPS ,FEDEX, BY AIR, BY SEA

DHL Express, FedEx and EMS for quantity less than 50KG, usually called as DDU service; 

Sea shipping for quantity over 500KG; And air shipping is available for 50KG above;

For high value products, please select air shipping and DHL express for safe;

Our Service:
1. Fast Delivery: We can delivery within 24 hours upon receipt of your payment.
2. Quality can be promised. Hot sell to Worldwide.
3. Payment Terms: T/T,, t/t
4. Free Sample available at any time.
5. Tracking your order at any time. Inform your order's further new situation at any time.
6. Package: Professional packing with professional materials.

 

Packing:  
  1. Inner double plastic bags----25kg/Fiber drum (35*35*45cm, GW: 28kg, NW: 25kg); 

  2. Inner double plastic bags----5kg/Aluminum foil bag (GW: 6.5kg, NW: 5kg). 

  3. Inner double plastic bags----1kg/Aluminum foil bag (GW: 1.5kg, NW: 1kg). 

P.S.: we accept packaging customization. 

  
Delivery:   

  1. Stock products are normally shipping within 3 working days.  

  2. For rush delivery, please contact our sales team for particular arrangement. 

Shipping Details: 
  1. We ship goods via DHL, Fedex, UPS, TNT, China post, NL Post and other couriers, weight from 10g to 1000kg or even bulker. 

  2. Shipping details & shipping documents will be provided and sent by email. 

  3. We keep tracking the shippment until clients well received. 

  4. After years export shipping experience, with professional and experienced cooperated forwarders, we ensure that goods can be delivered in multiple ways safetly and efficiently. 

About us

Our company specializes in processing and selling chemical raw materials, chemical products, pharmaceutical intermediates, veterinary medicine intermediates, dye intermediates, pigments, cosmetics raw materials and chemical reagents,  

We have compalete sales and service team , information feedback vertical integration of a sound marketing network, products are sold throughout the country and exported to South Asia, Europe, America, Africa and other more than 20 countries and regions.  

Companies adhering to the "pursuit of quality, innovation and development" business philosophy, to serve as a foundation, for the survival by the quality, seek development by science and technology, adhere to quilty comes first,fair price,good sense of customer service and responsibility. in the future hebei Nengqian import and export trade Co.,Ltd will always hold "integrity, innovation" business philosophy, to achieve honesty management, on the way of specialization, internationalization,  Keep moving!  

 

FAQ: 
1. Are you a trade company or factory   
We are a  factory with our own trading company.  

2.How do you control the quality   
Our factory is equipped with professional technicians to control quality, out inspectors take sample for testing every 2 hours to ensure the quality of our production. We also accept BV, SGS or any other Third-party inspection.   

3. How long is lead time   
We deliver goods within 3 days for small order, 7-10 days for bulk order.   

4. Where is your factory located  How can I visit the factory   
 Our factory located in HEBEI, China.

5. Can i get some samples  
  Yes, we can supply free sample, but the shipping cost be paid by our customers. 

6. How to start orders or make payments  
  Proforma invoice will be sent first after confirmation of order, enclosed our bank information.Payment by T/T,  

7. How to confirm the Product Quality before placing orders  
  You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. 
  You can send us your product specifications and requests,we will manufacture the products according to your requests. 

8. How long is lead time

We deliver goods within 3 days for small order, 7-10 days for bulk order.

 

9. How do you treat quality complaint

  First of all, our quality control will reduce the quality problem to near zero. If there is a realquality problem caused by us, we will send you free goods for replacement or refund your loss.