beta-Diphosphopyridine nucleotide 53-84-9

Details:

Product introduction:

Chemical & Physical Properties

Density	1.2±0.1 g/cm3
Boiling Point	758.6±60.0 °C at 760 mmHg
Melting Point	-83ºC
Molecular Formula	C40H62O19
Molecular Weight	846.909
Flash Point	296.6±32.9 °C
Exact Mass	846.388550
PSA	238.09000
LogP	8.46
Vapour Pressure	0.0±2.6 mmHg at 25°C
Index of Refraction	1.500

Physical and Chemical Properties

Chemical properties white powder, easy to absorb moisture, the aqueous solution is acidic. The solid is stable under dry conditions. The neutral or weakly acidic aqueous solution of this product can be stored for 7 days at room temperature, and it will accelerate deterioration and decomposition in case of alkali and heat. The specific rotation [α]23D-34.8 °(1%, water); its aqueous solution has the maximum absorption at 260nm and 340nm wavelengths. Easily soluble in water, insoluble in organic solvents such as acetone.

Use

Purpose 1. It is an essential coenzyme in vivo for biochemical research, clinical diagnosis, clinical drug and drug research. 2. Coenzyme drugs. Clinically, it is mainly used for adjuvant treatment of coronary heart disease, which can improve chest tightness, angina pectoris and other symptoms. Adverse reactions occasionally include dry mouth, dizziness, nausea, etc.

Uses and synthesis methods

Introduction

Nicotinamide adenine dinucleotide (abbreviated as NAD), also known as pyridine diphosphate nucleotide (abbreviated as DPN), or co-dehydrogenase I or coenzyme I. There are two states of oxidized (NAD) and reduced (NADH) in mammals. The oxidized (NAD) has the maximum ultraviolet absorption spectrum at 260nm. Through various deaminases, it accepts a hydrogen atom and an electron from the substrate., Becomes a reduced type (NADH), has the maximum absorption at 340nm.

β-nicotinamide adenine dinucleotide is used as a coenzyme in redox reactions, as a donor of ADP ribose moiety in ADP ribosylation reactions, and also as a second messenger molecule ring ADP ribose Precursor. β-nicotinamide adenine dinucleotide also acts as a substrate for bacterial DNA ligases and a group of enzymes called sirtuins that use NAD to remove acetyl groups from proteins.

Physiological functions and effects

Nicotinamide adenine dinucleotide participates in various physiological activities such as cell substance metabolism, energy synthesis, cell DNA repair, and plays an important role in the body's immune ability. In a healthy state, the concentration of nicotinamide adenine dinucleotide in the human body is stable, maintaining the normal function of various cells. The concentration of nicotinamide adenine dinucleotide in the body determines the process and degree of cell senescence, and the decrease of concentration will accelerate the process of cell senescence. Studies have shown that NAD has a protective effect on renal infarction caused by ischemic surgery, and can significantly reduce the levels of urea nitrogen and creatinine in serum. NAD has a protective effect on renal tubular injury caused by ischemic surgery. NAD (nicotinamide adenine dinucleotide, Nicotinamideadeninedinucleotide, referred to as NAD) can effectively protect kidney injury caused by renal ischemia. NAD has important application value in the preparation of drugs for the prevention and treatment of renal ischemic injury. In addition, nicotinamide adenine dinucleotide has certain applications in the preparation of drugs for the treatment of inflammatory pain. NAD participates in the regulation of formalin and complete Freund's adjuvant (CFA) through NAD-dependent deacetylase SIRT1 and SIRT2 participate in the inhibition of inflammatory pain by NAD through different mechanisms, thus achieving an analgesic effect on inflammatory pain.

Preparation

The preparation method of nicotinamide adenine dinucleotide proposed by CN201511022464.3 includes the following steps:

S1, broken cells: yeast cells are added into hydrochloric acid aqueous solution and soaked for 0.5-2.5h. after temperature difference wall breaking treatment, ceramic membrane is used for filtration, and the filtrate is taken to obtain clear liquid a;

S2, concentration: ultrafiltration of clear liquid a obtained from S1, nanofiltration of ultrafiltration to obtain concentrated liquid B, and adjusting the pH = 2-2.5 of concentrated liquid B with hydrochloric acid aqueous solution to obtain concentrated liquid c;

S3, elution: the concentrated solution c obtained in S2 is passed through D152 resin column, eluted with ammonia water, eluent d is collected, pH = 7-8 of eluent d is adjusted with hydrochloric acid aqueous solution, then the concentrated solution c is passed through 717 resin column, eluted with potassium chloride aqueous solution, and comprehensive solution e is collected;

S4, separation: nanofiltration of composite liquid e obtained in S3 to obtain concentrated solution f; Adjust the pH = 1-3 of concentrated solution f with nitric acid aqueous solution, add acetone to precipitate, and centrifuge to obtain solid g;

S5, purification: the solid G obtained in S4 is dissolved in water, subjected to preparative chromatography, desalination, separation, collection of separation liquid, concentration, freeze-drying to obtain nicotinamide adenine dinucleotide.

Production method

yeast is extracted in boiling water, lead acetate is acidified and precipitated to obtain crude product, which is treated with formic acid cation exchange resin column and refined.

 

Our company specializes in processing and selling chemical raw materials, chemical products, pharmaceutical intermediates, veterinary medicine intermediates, dye intermediates, pigments, cosmetics raw materials and chemical reagents,  

Our company has a number of sales team, service and information feedback vertical integration of a sound marketing network, products are sold throughout the country and exported to South Asia, Europe, America, Africa and other more than 20 countries and regions.  

Companies adhering to the "pursuit of quality, innovation and development" business philosophy, to serve as a foundation, for the survival by the quality, seek development by science and technology, adhere to quilty comes first,fair price,good sense of customer service and responsibility. in the future hebei Nengqian import and export trade Co.,Ltd will always hold "integrity, innovation" business philosophy, to achieve honesty management, on the way of specialization, internationalization,  Keep moving!  

 

 

 

 

 

Our advantages: 

1, High quality with competitive price:

1) Standard:BP/USP/EP/Enterprise standard

2) All Purity≥99%

3) We are manufacturer and can provide high quality products with factory price.

 2, Fast and safe delivery

1) Parcel can be sent out in 24 hours after payment.Tracking number available

2) Secure and discreet shipment.Various transportation methods for your choice.

3) Customs pass rate ≥99%

4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe,

and we have stock in there for transferring.

Product Packaging：

1) 1kg/bag (1kg net weight, 1.1kg gross weight, packed in an aluminum foil bag)

2) 25kg/drum (25kg net weight, 28kg gross weight; Packed in a cardboard-drum with two plastic-bags inside; Drum Size: 510mm high, 360mm diameter)

 Storage：

Stored in a cool and dry well-closed container. Keep away from moisture and strong light/heat.

Delivery：

Usually within3-5 working days after full payment.

transport：

EMS,DHL, TNT, UPS ,FEDEX, BY AIR, BY SEA

DHL Express, FedEx and EMS for quantity less than 50KG, usually called as DDU service; 

Sea shipping for quantity over 500KG; And air shipping is available for 50KG above;

For high value products, please select air shipping and DHL express for safe;

Our Service:
1. Fast Delivery: We can delivery within 24 hours upon receipt of your payment.
2. Quality can be promised. Hot sell to Worldwide.
3. Payment Terms: T/T,, t/t
4. Free Sample available at any time.
5. Tracking your order at any time. Inform your order's further new situation at any time.
6. Package: Professional packing with professional materials.

FAQ: 
1.Are you a trade company or factory   
We are a  factory with our own trading company.  

2.How do you control the quality   
Our factory is equipped with professional technicians to control quality, out inspectors take sample for testing every 2 hours to ensure the quality of our production. We also accept BV, SGS or any other Third-party inspection.   

3.How long is lead time   
We deliver goods within 3 days for small order, 7-10 days for bulk order.   

4. Where is your factory located  How can I visit the factory   
 Our factory located in HEBEI, China.

5.Can i get some samples  
  Yes, we can supply free sample, but the shipping cost be paid by our customers. 

6.How to start orders or make payments  
  Proforma invoice will be sent first after confirmation of order, enclosed our bank information.Payment by T/T,  

7. How to confirm the Product Quality before placing orders  
  You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. 
8. How long is lead time

We deliver goods within 3 days for small order, 7-10 days for bulk order.

 

9. How do you treat quality complaint

  First of all, our quality control will reduce the quality problem to near zero. If there is a realquality problem caused by us, we will send you free goods for replacement or refund your loss.