Betulinic acid 472-15-1

Details:

Product introduction:

Melting Point	295-298 °C (dec.) (lit.)
Boling Point	550.0±33.0 °C(Predicted)
Specific Rotation(α)	D25 +7.5° (c = 0.37 in pyridine)
Flash Point	299.4°C
Solubility	Insoluble in water, slightly soluble in methanol, ethanol, acetone, easily soluble in tetrahydrofuran, pyridine.
Vapor Presure	2.67E-14mmHg at 25°C
Appearance	White crystal
Color	White or off-white
Merck	14,1190
pKa	4.61±0.70(Predicted)
Storage Condition	2-8°C
Stability	Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
Refractive Index	7.8 ° (C=0.9, Pyridi
MDL	MFCD00009619
Physical and Chemical Properties	Melting point 295-298°C (dec.).

Reference Information

Introduction	Betulinic acid is a pentacyclic triterpenoid compound, which is widely present in the natural world. It was first isolated from the bark of Rhamnaceae evergreen plants growing in eastern Africa, but the main source is extracted and purified from birch bark. In recent years, scientific research has found that BA is a very valuable natural product. BA and its derivatives have shown great potential in anti-cancer and HIV treatment as biological agents. They play an important role in the body's antioxidant damage and immune regulation process. They are a class of potential drug lead compounds and have important value for the research and development of new drugs. NCI of the American Cancer Institute has included them in the Rapid Research and Development Program (RAID).
properties	light yellow to white crystalline powder; The air is slight and the taste is bitter.
use	has anti-tumor, lowering blood pressure, anti-peptic ulcer and gastrointestinal dysfunction, and treats liver diseases. 1. Anti-inflammatory effect Most pentacyclic triterpenoids have anti-inflammatory activity. The anti-inflammatory effect of betulinic acid has been verified in the model system in vivo and in vitro. It can inhibit PGE2 production and reduce inflammatory response. 2. The antibacterial effect has a certain antibacterial effect, which can inhibit a variety of bacteria including Escherichia coli, Bacillus subtilis, Staphylococcus aureus and Staphylococcus epidermidis. 3. Antiviral effect has more prominent antiviral activity, especially anti-HIV activity, and has an effective effect on anti-hepatitis C virus, anti-spore rash virus, anti-Eco virus, anti-influenza virus, etc. 4. Anti-hyperlipidemia effects Studies have found that betulinic acid and its derivatives can play an anti-hyperlipidemia effect by regulating adipokines, reducing lipid production, and reducing triacylglycerol and total cholesterol levels. 5. Anti-diabetic effect has shown good efficacy in the treatment of diabetes, which is mainly treated by inhibiting α-amylase and α-glucosidase to reduce the hydrolysis of polysaccharides and promote glycogen synthesis. 6. Antioxidant stress activity BA has protective effect on normal cells and body, which is related to antioxidant stress. For example, betulinic acid has a protective effect on ischemia-reperfusion injury in the brain, kidney and heart. BA has protective effects on ischemia-reperfusion brain injury in mice by anti-oxidative stress, anti-nitriding stress and increasing blood flow. Other diseases have now been found to improve Alzheimer's disease. Its protective effect is mainly through weakening neurobehavioral and cognitive dysfunction, reducing pro-inflammatory cytokines in the hippocampus, and reducing oxidation and nitrosation. At the same time, there are also reports that betulinic acid has a certain anti-anxiety effect, and some anti-anxiety drugs have been used in its components. Betulinic acid has a strong inhibitory effect on human melanoma, human colon cancer, and completely inhibits the growth of athymic mice with human melanoma. A pentacyclic triterpenoid compound that selectively induces tumor cell apoptosis through the mitochondrial pathway that directly activates apoptosis through p53 and CD95 independent mechanisms.
production method	first, extracted and separated from natural plants. This method consumes a large amount of solvent, the yield is low, and the impurities are not easy to separate, so it is rarely used; second, betulinic acid is obtained by organic synthesis with betulin as the precursor. This method has been applied to industrial production, and industrial-scale betulinic acid can be obtained, which is the main source of betulinic acid on the market; third, betulinic acid is generated by microbial transformation with betulinic alcohol as a precursor. This method represents the new direction of the future plant extraction industry, but there are still many technical problems that cannot be solved.
Preparation	Microbial transformation method uses enzymes produced in the metabolic process to catalyze the substrate to obtain the target product. Compared with chemical synthesis methods, microbial transformation has high stereoselectivity, mild reaction conditions, low pollution and low cost. This method has the potential for industrialization. Feng et al. catalyzed betulin direct microbial transformation to produce BA by culturing Armillaria luteovirens ZJUQH100-6 and Cunninghamella blakesleeana cells. In addition, some studies have used the biotechnology of inducing BA production from callus of Ocimi species for the first time to improve the yield of BA. This study provides a new method for the preparation of BA and other anticancer triterpenes. Recently, it has been reported that the whole metabolic pathway of BA in plants was substituted into yeast cells, and BA was successfully synthesized by microorganisms. Studies have found that the metabolic flow balance of fatty acid and terpenoid precursor synthesis pathways has a significant effect on BA synthesis, and the production of BA is significantly increased by co-expression of key regulatory genes (HFA1, HMG1 and ERG9) in these two metabolic pathways. The engineering bacteria can synthesize mg-level BA per liter of culture medium, thus, the preparation and synthesis of BA has risen to a new level.

 

Our company specializes in processing and selling chemical raw materials, chemical products, pharmaceutical intermediates, veterinary medicine intermediates, dye intermediates, pigments, cosmetics raw materials and chemical reagents,  

Our company has a number of sales team, service and information feedback vertical integration of a sound marketing network, products are sold throughout the country and exported to South Asia, Europe, America, Africa and other more than 20 countries and regions.  

Companies adhering to the "pursuit of quality, innovation and development" business philosophy, to serve as a foundation, for the survival by the quality, seek development by science and technology, adhere to quilty comes first,fair price,good sense of customer service and responsibility. in the future hebei Nengqian import and export trade Co.,Ltd will always hold "integrity, innovation" business philosophy, to achieve honesty management, on the way of specialization, internationalization,  Keep moving!  

 

 

 

 

 

Our advantages: 

1, High quality with competitive price:

1) Standard:BP/USP/EP/Enterprise standard

2) All Purity≥99%

3) We are manufacturer and can provide high quality products with factory price.

 2, Fast and safe delivery

1) Parcel can be sent out in 24 hours after payment.Tracking number available

2) Secure and discreet shipment.Various transportation methods for your choice.

3) Customs pass rate ≥99%

4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe,

and we have stock in there for transferring.

Product Packaging：

1) 1kg/bag (1kg net weight, 1.1kg gross weight, packed in an aluminum foil bag)

2) 25kg/drum (25kg net weight, 28kg gross weight; Packed in a cardboard-drum with two plastic-bags inside; Drum Size: 510mm high, 360mm diameter)

 Storage：

Stored in a cool and dry well-closed container. Keep away from moisture and strong light/heat.

Delivery：

Usually within3-5 working days after full payment.

transport：

EMS,DHL, TNT, UPS ,FEDEX, BY AIR, BY SEA

DHL Express, FedEx and EMS for quantity less than 50KG, usually called as DDU service; 

Sea shipping for quantity over 500KG; And air shipping is available for 50KG above;

For high value products, please select air shipping and DHL express for safe;

Our Service:
1. Fast Delivery: We can delivery within 24 hours upon receipt of your payment.
2. Quality can be promised. Hot sell to Worldwide.
3. Payment Terms: T/T,, t/t
4. Free Sample available at any time.
5. Tracking your order at any time. Inform your order's further new situation at any time.
6. Package: Professional packing with professional materials.

FAQ: 
1.Are you a trade company or factory   
We are a  factory with our own trading company.  

2.How do you control the quality   
Our factory is equipped with professional technicians to control quality, out inspectors take sample for testing every 2 hours to ensure the quality of our production. We also accept BV, SGS or any other Third-party inspection.   

3.How long is lead time   
We deliver goods within 3 days for small order, 7-10 days for bulk order.   

4. Where is your factory located  How can I visit the factory   
 Our factory located in HEBEI, China.

5.Can i get some samples  
  Yes, we can supply free sample, but the shipping cost be paid by our customers. 

6.How to start orders or make payments  
  Proforma invoice will be sent first after confirmation of order, enclosed our bank information.Payment by T/T,  

7. How to confirm the Product Quality before placing orders  
  You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. 
8. How long is lead time

We deliver goods within 3 days for small order, 7-10 days for bulk order.

 

9. How do you treat quality complaint

  First of all, our quality control will reduce the quality problem to near zero. If there is a realquality problem caused by us, we will send you free goods for replacement or refund your loss.