Details:

Our advantage:

1. High quality with competitive price:

1) Standard:BP/USP/EP/Enterprise standard

2) All Purity≥99%

3) We are manufacturer and can provide high quality products with factory price.

 2, Fast and safe delivery

1) Parcel can be sent out in 24 hours after payment.Tracking number available

2) Secure and discreet shipment.Various transportation methods for your choice.

3) Customs pass rate ≥99%

4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe,

and we have stock in there for transferring.

Boling Point	502.79°C (rough estimate)
Specific Rotation(α)	D20 +83.3° (c = 0.6 in chloroform)
Flash Point	302.6°C
Solubility	Soluble in methanol, ethanol, benzene, ether, acetone and chloroform, almost insoluble in water.
Vapor Presure	1.47E-14mmHg at 25°C
Appearance	White needle crystal
Color	light yellow
Merck	14,6827
pKa	2.52(at 25℃)
Storage Condition	2-8°C
Refractive Index	1.4940 (estimate)
MDL	MFCD00064914
Physical and Chemical Properties	Melting point> 300°C
Use	Suitable for all types of hepatitis, with the promotion of liver cell regeneration, accelerate the repair of damaged liver cells, and strong heart, diuretic and anti-inflammatory effects

Preparation Method

Open Data Verified Data

• wood and wood root bark was cut into small pieces or filamentous by alcohol extraction, refluxed with 70% ml of ethanol for 3 times, about 3h each time, and the alcohol extracts were combined; Then most of the ethanol was recovered by distillation, add sulfuric acid to make the concentration of 15%, reflux for 2H, cool and filter, wash the filter cake with water for 3 times, then boil with 3% NaOH solution for 2 times, boil with water for 1 time, after each boiling filtration, can be gray-white crude sodium salt. Add about 8 times the amount of 85% ethanol, 0.5% activated carbon, reflux 40 min, filter, filtrate with HC1 to pH 3~4, overnight, filter, the filter cake was washed with distilled water to no chloride ion, and dried to obtain oleanolic acid fine product.
• after the block of wood and wood root bark was crushed by water extraction method, it was decocted with water for 3 times, about th each time, and the combined water decoction was concentrated into a dilute paste; Then concentrated sulfuric acid was added and stirred continuously, make its concentration to 20%, heat about th, cool and dilute with water, filter, filter cake after washing, with 3 %NaOH solution boiling 2 times, water boiling 1 times, after each boiling, the crude sodium salt was obtained by filtration. Add about 8 times the amount of more than 85% ethanol, 0.5% activated carbon, reflux 40 min, filter, and then adjust the filtrate to pH 3~4 with HC1, place overnight, filter, the filter cake is washed with distilled water to no chloride ion and dried to obtain this product.

 

 

use	has the effects of protecting liver and reducing enzymes, promoting liver cell regeneration, anti-inflammatory, cardiotonic, diuretic, anti-tumor, etc., and also has the effects of lowering blood sugar, lowering blood lipids, Sedative effect, is an effective ingredient in drugs such as treating liver disease and lowering blood sugar. It is clinically used to treat infectious acute icteric hepatitis. It has a significant effect of reducing glutamic pyruvic transaminase and reducing yellowing, improving the symptoms, signs and liver function of patients with viral and chronic persistent hepatitis; it can also be used for psoriasis, Rheumatoid arthritis, nephritis and edema, liver cirrhosis and ascites, acute and chronic hepatitis, stomach pain and turbidity, blood collapse, bruises, carbuncle swelling, waist and knee weakness, fetal movement and other symptoms. It is suitable for various types of hepatitis. It can promote the regeneration of liver cells, accelerate the repair of damaged liver cells, and has strong, diuretic and anti-inflammatory effects. liver disease adjuvant oleanolic acid is a natural triterpenoid compound, widely exists in food and medicinal plants. A triterpenoid compound isolated from medicinal plants. Anti-tumor and hepatoprotective agents. It was used as a reference compound in quantification by high-performance thin-layer chromatography (HPTLC) in the roots of the genus Stannia.
Ligustrum lucidum extract	Oleanolic acid is a pentacyclic triterpenoid compound isolated and extracted from the fruit of the Gentianaceae plant Swertia or Ligustrum lucidum. It exists in a variety of plants as free bodies and glycobodies. It has become a commonly used liver-protecting drug in clinical practice. It has a significant protective effect on acute and chronic liver damage in rats caused by carbon tetrachloride, it can reduce the elevated ALT and AST, reduce inflammation, necrosis and interstitial inflammation, prevent the formation of fibrosis, promote the regeneration of liver cells, and accelerate the recovery of necrotic tissue. Electron microscopy showed that the enlarged mitochondria and rough endoplasmic reticulum recovered after treatment with oleanolic acid. Its succinate can reduce the activity of cytochrome P450 enzyme in mouse liver microsomes. In addition, oleanolic acid has the effects of correcting protein metabolism disorders, reducing inflammation, strengthening the heart, diuresis, increasing white blood cells, lowering blood sugar, promoting immune function, and inhibiting the growth of S-180 tumor strains. The following figure shows the technological process of extracting oleanolic acid and ursolic acid from the dried and mature fruits of Ligustrum lucidum from the Oleaceae plant: the technological flow chart of extracting oleanolic acid from the mature fruits of Ligustrum lucidum [note 1] 95% ethanol reflux extraction 4 times, combine the extracts, and concentrate under reduced pressure. [Note 2] After dilute alcohol is dissolved, petroleum ether, ethyl acetate and n-butanol are respectively extracted. [note 3] low pressure silica gel column chromatography, petroleum ether-ethyl acetate gradient elution.
The effect of oleanolic acid	1. Oleanolic acid has anti-inflammatory, sedative, cardiotonic, diuresis, lowering blood lipids, lowering blood sugar, protecting liver and reducing enzymes, enhancing immunity and inhibiting the growth of S180 tumor strains. It is an effective ingredient in the development of drugs for the treatment of liver disease and lowering blood sugar. 2. Oleanolic acid has protective effect on chromosome damage and preventive effect on experimental atherosclerosis. It is clinically used to treat infectious acute icteric hepatitis and chronic viral hepatitis. It has obvious effects of reducing glutamic-pyruvic transaminase and reducing yellow. 3. oleanolic acid has the effect of inhibiting liver fibrosis. in rats with liver fibrosis treated with oleanolic acid, liver fibrosis has severe and significantly reduced liver fibrosis, and liver collagen content is reduced, suggesting that it has the effect of preventing and treating liver cirrhosis. 4, reduce the brain homogenate of cirrhotic rats cool acid level: because the brain homogenate cool acid level decreased significantly, can inhibit the production of pseudo neurotransmitter, so it is conducive to the prevention and treatment of hepatic encephalopathy. 5. Oleanolic acid capsules are non-prescription drugs for liver disease, which are used for the adjuvant treatment of acute and chronic hepatitis. It has a certain protective effect on liver injury, which can reduce the elevated serum alanine aminotransferase, promote the regeneration of liver cells, and accelerate the repair of necrotic tissue.
Olean fruit	Olean fruit, also known as "olive", is a very typical woody oil plant in the Mediterranean region. Belongs to Oleaceae. The ancient Greeks and Jews took the fruit of the year as a sign of peace. In western spotted teeth, Italy and Argentina, oleuncularine occupies a huge area. It is less distributed elsewhere. Olean fruit is a tree with a height of 3-7 meters. Its leaves are evergreen and drupe are as long as 1-3cm. Its mesocarp contains 25-40% olean oil, rich in vitamins and is easy to be digested by organisms. In medicine, this oil is used to prevent arteriosclerosis. At present, it mainly grows in cultivated or wild state. There are about 60 species in Olea, such as olea chrysophylla, O.europaea and oleaeuropaea var. communis. Olean fruit plant map
clinical application	oleanolic acid is an anti-hepatitis drug. clinically, it is mainly used to treat acute icteric hepatitis with remarkable curative effect and good effect on chronic hepatitis. The symptoms, signs and liver function were significantly improved. In addition, there is the role of correcting protein metabolism disorders.

 

 

Product Packaging：

1) 1kg/bag (1kg net weight, 1.1kg gross weight, packed in an aluminum foil bag)

2) 25kg/drum (25kg net weight, 28kg gross weight; Packed in a cardboard-drum with two plastic-bags inside; Drum Size: 510mm high, 360mm diameter)

 Storage：

Stored in a cool and dry well-closed container. Keep away from moisture and strong light/heat.

Delivery：

Usually within3-5 working days after full payment.

transport：

EMS,DHL, TNT, UPS ,FEDEX, BY AIR, BY SEA

DHL Express, FedEx and EMS for quantity less than 50KG, usually called as DDU service; 

Sea shipping for quantity over 500KG; And air shipping is available for 50KG above;

For high value products, please select air shipping and DHL express for safe;

Our Service:
1. Fast Delivery: We can delivery within 24 hours upon receipt of your payment.
2. Quality can be promised. Hot sell to Worldwide.
3. Payment Terms: T/T,, t/t
4. Free Sample available at any time.
5. Tracking your order at any time. Inform your order's further new situation at any time.
6. Package: Professional packing with professional materials.

 

Packing:  
  1. Inner double plastic bags----25kg/Fiber drum (35*35*45cm, GW: 28kg, NW: 25kg); 

  2. Inner double plastic bags----5kg/Aluminum foil bag (GW: 6.5kg, NW: 5kg). 

  3. Inner double plastic bags----1kg/Aluminum foil bag (GW: 1.5kg, NW: 1kg). 

P.S.: we accept packaging customization. 

  
Delivery:   

  1. Stock products are normally shipping within 3 working days.  

  2. For rush delivery, please contact our sales team for particular arrangement. 

Shipping Details: 
  1. We ship goods via DHL, Fedex, UPS, TNT, China post, NL Post and other couriers, weight from 10g to 1000kg or even bulker. 

  2. Shipping details & shipping documents will be provided and sent by email. 

  3. We keep tracking the shippment until clients well received. 

  4. After years export shipping experience, with professional and experienced cooperated forwarders, we ensure that goods can be delivered in multiple ways safetly and efficiently. 

About us

Our company specializes in processing and selling chemical raw materials, chemical products, pharmaceutical intermediates, veterinary medicine intermediates, dye intermediates, pigments, cosmetics raw materials and chemical reagents,  

We have compalete sales and service team , information feedback vertical integration of a sound marketing network, products are sold throughout the country and exported to South Asia, Europe, America, Africa and other more than 20 countries and regions.  

Companies adhering to the "pursuit of quality, innovation and development" business philosophy, to serve as a foundation, for the survival by the quality, seek development by science and technology, adhere to quilty comes first,fair price,good sense of customer service and responsibility. in the future hebei Nengqian import and export trade Co.,Ltd will always hold "integrity, innovation" business philosophy, to achieve honesty management, on the way of specialization, internationalization,  Keep moving!  

 

FAQ: 
1. Are you a trade company or factory   
We are a  factory with our own trading company.  

2.How do you control the quality   
Our factory is equipped with professional technicians to control quality, out inspectors take sample for testing every 2 hours to ensure the quality of our production. We also accept BV, SGS or any other Third-party inspection.   

3. How long is lead time   
We deliver goods within 3 days for small order, 7-10 days for bulk order.   

4. Where is your factory located  How can I visit the factory   
 Our factory located in HEBEI, China.

5. Can i get some samples  
  Yes, we can supply free sample, but the shipping cost be paid by our customers. 

6. How to start orders or make payments  
  Proforma invoice will be sent first after confirmation of order, enclosed our bank information.Payment by T/T,  

7. How to confirm the Product Quality before placing orders  
  You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. 
  You can send us your product specifications and requests,we will manufacture the products according to your requests. 

8. How long is lead time

We deliver goods within 3 days for small order, 7-10 days for bulk order.

 

9. How do you treat quality complaint

  First of all, our quality control will reduce the quality problem to near zero. If there is a realquality problem caused by us, we will send you free goods for replacement or refund your loss.