Details:

Our advantage:

1. High quality with competitive price:

1) Standard:BP/USP/EP/Enterprise standard

2) All Purity≥99%

3) We are manufacturer and can provide high quality products with factory price.

 2, Fast and safe delivery

1) Parcel can be sent out in 24 hours after payment.Tracking number available

2) Secure and discreet shipment.Various transportation methods for your choice.

3) Customs pass rate ≥99%

4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe,

and we have stock in there for transferring.

Density	1.843±0.06 g/cm3(Predicted)
Melting Point	269-270°C
Boling Point	842.7±65.0 °C(Predicted)
Specific Rotation(α)	+43.3°（c=0.9，pyridine）
Flash Point	303.6°C
Solubility	Slightly soluble in methanol, ethanol, water, soluble in hot dilute methanol, hot dilute ethanol, insoluble in non-polar solvents.
Vapor Presure	3.67E-30mmHg at 25°C
Appearance	Light gray yellow needle crystal
Color	Pale Yellow
pKa	6.09±0.20(Predicted)
Storage Condition	2-8°C
Refractive Index	1.788
MDL	MFCD00075656
Physical and Chemical Properties	Fruit derived from the plant Mangifera indica L.

Reference Information

Overview	Mangiferin (mangiferin), also known as Guanzhenning or Mangoin, is a tetrahydroxypyridone carbocarbon glycoside, which belongs to diphenylpyridone Flavonoids, mainly derived from the dry rhizome of the Liliaceae perennial herb Anemarrhena, the leaves, fruits, and bark of the plants almond and mango, the roots of the five-layer dragon plant of the genus Pterodactylaceae, Hainan, etc.; it has cough, asthma and expectorant, immune, anti-inflammatory and analgesic, liver and gallbladder, anti-lipid peroxidation, anti-cancer, anti-diabetes, antibacterial, anti-virus and other pharmacological activities. At present, the main clinical applications are Mango Zhike Tablets, Mango Zhike Capsules, Mangiferin Tablets, Mangiferin Dropping Pills, and these drugs are only used for respiratory diseases. Fig. 1 is the structural formula of mangiferin
Mango	Mango, a plant of the Lacquer family, records in "Kaibao Materia Medica" that food quenches thirst, leaves are decocted in soup to cure thirst; "Compendium of Materia Medica" records that it is the best in fruit; "Compendium of Materia Medica" records the effects of mango on stomach qi and vomiting. The present study found that mangiferin in branches, leaves and bark of mango has a wide range of pharmacological effects such as anti-inflammatory, antipyretic and analgesic, antibacterial, immune regulation, hypoglycemic, antioxidant, etc.
pharmacological action	1. antioxidant effect due to the particularity of mangiferin structure, there are multiple phenolic hydroxyl groups in the molecule, and phenolic hydroxyl groups happen to be important groups for scavenging free radicals and reactive oxygen species. The mechanism of its action on free radicals can be attributed to two aspects: on the one hand, it directly acts on scavenging free radicals, and on the other hand, it acts on iron and copper ions to reduce its further reaction with free radicals. 2. The occurrence of anti-tumor leukemia is related to the disorder of cell cycle regulation, and there is a close relationship between cell cycle regulation and telomerase activity expression. Therefore, the study of abnormal regulation of telomerase and cell cycle has become a new direction to explore the occurrence and treatment of leukemia. The occurrence of leukemia is related to the disorder of cell cycle regulation, and there is a close relationship between cell cycle regulation and telomerase activity expression. Therefore, the study of abnormal regulation of telomerase and cell cycle has become a new direction to explore the occurrence and treatment of leukemia. 3. Neuroprotective effect Mangiferin with polyphenol structure can protect neurons by reducing the degree of Ca2 + influx and oxidative stress, thus reducing the cell death caused by glutamate in neurons. 4. Antiviral effect has anti-herpes simplex virus type I (HSV-I) effect in vitro, with a plaque reduction rate of 56.8%. Its antiviral effect is attributed to its ability to inhibit intracellular virus replication. 5. The antipyretic effect has a good antipyretic effect on the experimental animal model of fever caused by endotoxin, and is positively correlated with the dose, which has a good protective effect on heat injury. 6. Analgesic effect has significant analgesic effect on pain induced by acetic acid and hot plate test. Compared with naloxone hydrochloride, it is found that mangiferin-induced pain loss is not dependent on opioid receptors, its analgesic effect is significant, and its effect on peripheral nerves is slight. 7. Anti-parasitic effect Mangiferin has obvious inhibitory effect on Cryptosporidium parvum in young rats. Effect of mangiferin on mice infected with nematodes, Trichinella spiralis. 8. Anti-diabetic Effect After oral administration of mangiferin and glucoside, the blood sugar level of normal mice has no change, but it can reduce the blood sugar concentration of mice KK-Ay spontaneous diabetes animal model, and the insulin level in serum also has a decreasing trend. Fruit glycosides and their glucosides may show antidiabetic activity through insulin sensitization. 9. The protective effect of protecting liver and choleretic effect on liver. Mangiferin has the effect of stabilizing lysosomal membrane and directly inhibiting the activity of lysosomal acid phosphatase. Mangiferin also has obvious choleretic effect. 10. Effect on Central Nervous System Mangiferin has obvious excitatory effect on Central Nervous System. Mangiferin has the effect of removing lipid peroxides in brain tissue, reducing the damage of lipid peroxides to neurons, thereby protecting the normal function of neurons. 11. It has adrenal glucocorticoid-like anti-inflammatory effect on the respiratory system, can reduce capillary permeability, and its anti-inflammatory response rate reaches 38%. Due to the anti-inflammatory effect of mangiferin, it has a certain effect on bronchial asthma, which is manifested as ①It can make the asthma induction time significantly longer than that of the asthma group; ②It reduces the degree of asthma and the incidence of convulsions is significantly lower than that of the asthma group; ③The emphysema is significantly reduced, the inflammatory cell infiltration in the lung is significantly less than that of the asthma group, and the lung/body weight ratio is significantly lower than that of the asthma group, which is close to the dexamethasone group. At the same time, mangiferin can reduce the levels of serum NO and endothelin-1 (ET-1) in alveolar lavage fluid, and play a certain preventive role in asthma attack. The combination of mangiferin and dexamethasone can improve the curative effect.
extraction method	1. organic solvent extraction process uses more than 90% ethanol as extraction solvent, and high purity mangiferin can be extracted from mango leaves. 2. Water-based solvent extraction process uses weak alkaline water as the extraction solvent to extract mangiferin from mango leaves, and the extract is successively eluted by D101 column macroporous resin and D301 column impurity removal and decolorization. This high-purity mangiferin extraction process is suitable for industrial production. 3. Enzymatic extraction process uses cellulase to extract mangiferin from mango leaves. The experimental conditions are as follows: enzymolysis PH is 5.0, temperature is 55 ℃, time is 2h. 4. Ultrasonic-assisted extraction process Ultrasonic-assisted extraction process has the advantages of simplicity, short time consumption, energy saving, etc., and has good development and application prospects. (2016-02-01)
clinical application	1. for the treatment of upper respiratory tract infection.
use	used for content determination/identification/pharmacological experiments, etc. Pharmacological effects: This product has inhibitory effects on the central nervous system, anti-inflammatory, antibacterial, anti-herpes simplex virus, choleretic and immune effects, and has a protective effect on simulated high altitude acute hypoxia liver injury. Pharmacological experiments have shown that this product has a good effect in the treatment of chronic bronchitis. It is the main active ingredient in the treatment of hepatitis with Tibetan Artemisia artemisiae and the antiviral active ingredient in the rhizome of Anemarrhena. a natural phenolic flavonoids, can be used as anti-microbial or anti-diabetic drugs for research, with anti-inflammatory and antioxidant activities. Mangiferin can be used to help identify and characterize type II 5-α-reductase. MGF can be used as a reference substance for the analysis of flavonoids. MGF may act as a promoter of gastrointestinal transport (GIT).

Product Packaging：

1) 1kg/bag (1kg net weight, 1.1kg gross weight, packed in an aluminum foil bag)

2) 25kg/drum (25kg net weight, 28kg gross weight; Packed in a cardboard-drum with two plastic-bags inside; Drum Size: 510mm high, 360mm diameter)

 Storage：

Stored in a cool and dry well-closed container. Keep away from moisture and strong light/heat.

Delivery：

Usually within3-5 working days after full payment.

transport：

EMS,DHL, TNT, UPS ,FEDEX, BY AIR, BY SEA

DHL Express, FedEx and EMS for quantity less than 50KG, usually called as DDU service; 

Sea shipping for quantity over 500KG; And air shipping is available for 50KG above;

For high value products, please select air shipping and DHL express for safe;

Our Service:
1. Fast Delivery: We can delivery within 24 hours upon receipt of your payment.
2. Quality can be promised. Hot sell to Worldwide.
3. Payment Terms: T/T,, t/t
4. Free Sample available at any time.
5. Tracking your order at any time. Inform your order's further new situation at any time.
6. Package: Professional packing with professional materials.

 

Packing:  
  1. Inner double plastic bags----25kg/Fiber drum (35*35*45cm, GW: 28kg, NW: 25kg); 

  2. Inner double plastic bags----5kg/Aluminum foil bag (GW: 6.5kg, NW: 5kg). 

  3. Inner double plastic bags----1kg/Aluminum foil bag (GW: 1.5kg, NW: 1kg). 

P.S.: we accept packaging customization. 

  
Delivery:   

  1. Stock products are normally shipping within 3 working days.  

  2. For rush delivery, please contact our sales team for particular arrangement. 

Shipping Details: 
  1. We ship goods via DHL, Fedex, UPS, TNT, China post, NL Post and other couriers, weight from 10g to 1000kg or even bulker. 

  2. Shipping details & shipping documents will be provided and sent by email. 

  3. We keep tracking the shippment until clients well received. 

  4. After years export shipping experience, with professional and experienced cooperated forwarders, we ensure that goods can be delivered in multiple ways safetly and efficiently. 

About us

Our company specializes in processing and selling chemical raw materials, chemical products, pharmaceutical intermediates, veterinary medicine intermediates, dye intermediates, pigments, cosmetics raw materials and chemical reagents,  

We have compalete sales and service team , information feedback vertical integration of a sound marketing network, products are sold throughout the country and exported to South Asia, Europe, America, Africa and other more than 20 countries and regions.  

Companies adhering to the "pursuit of quality, innovation and development" business philosophy, to serve as a foundation, for the survival by the quality, seek development by science and technology, adhere to quilty comes first,fair price,good sense of customer service and responsibility. in the future hebei Nengqian import and export trade Co.,Ltd will always hold "integrity, innovation" business philosophy, to achieve honesty management, on the way of specialization, internationalization,  Keep moving!  

 

FAQ: 
1. Are you a trade company or factory   
We are a  factory with our own trading company.  

2.How do you control the quality   
Our factory is equipped with professional technicians to control quality, out inspectors take sample for testing every 2 hours to ensure the quality of our production. We also accept BV, SGS or any other Third-party inspection.   

3. How long is lead time   
We deliver goods within 3 days for small order, 7-10 days for bulk order.   

4. Where is your factory located  How can I visit the factory   
 Our factory located in HEBEI, China.

5. Can i get some samples  
  Yes, we can supply free sample, but the shipping cost be paid by our customers. 

6. How to start orders or make payments  
  Proforma invoice will be sent first after confirmation of order, enclosed our bank information.Payment by T/T,  

7. How to confirm the Product Quality before placing orders  
  You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. 
  You can send us your product specifications and requests,we will manufacture the products according to your requests. 

8. How long is lead time

We deliver goods within 3 days for small order, 7-10 days for bulk order.

 

9. How do you treat quality complaint

  First of all, our quality control will reduce the quality problem to near zero. If there is a realquality problem caused by us, we will send you free goods for replacement or refund your loss.