D-Mannitol 69-65-8

Details:

Product introduction:

Melting Point	167°C
Boling Point	494.9°C
Specific Rotation(α)	141 o (C= USP-DIRECTIVES)
Flash Point	292.6°C
Water Solubility	177.3g/L(25 ºC)
Solubility	Soluble in water, slightly soluble in ethanol
Vapor Presure	7.22E-12mmHg at 25°C
Appearance	White needle crystal
pKa	pKa 13.50(H2O,t =18)(Approximate)
Storage Condition	Inert atmosphere,Room Temperature
Sensitive	Easily absorbing moisture
Refractive Index	1.5970 (estimate)
MDL	MFCD00064287
Physical and Chemical Properties	Density 1.52 melting point 167-170°C boiling point 295°C specific optical rotation 141 ° (c = USP-directives) water-soluble soluble properties mannitol is a six-membered alcohol, white needle-like crystal, taste like glucose soluble in water and hot methanol, ethanol, insoluble in ether
Use	Used as analytical reagents, but also for the synthesis of resins and drugs

• This product is polyol sugar, 07% aqueous solution and serum osmotic pressure is equal. Its hypertonic solution has a dehydrating and diuretic effect. It is rarely absorbed in the intestine after oral administration. Intravenous injection is mainly distributed in the extracellular fluid. In the body only a small part of the liver into glycogen, most unchanged and excreted from the urine. Intravenous injection or intravenous drip 10 minutes began to have diuretic effect, 2~3 hours to reach the peak, maintain 6~8 hours. Dehydration reduced intracranial pressure within 15 minutes, lasting 3 to 8 hours, reducing intraocular pressure 30 to 60 minutes, lasting 4 to 6 hours. In nature, mannitol widely exists in all kinds of plants. The content of mannitol is as high as 30% ~ so% in the sap of Fraxinus luteinidae, and it is also contained in edible fungi, lichens, carrots and so on. The content of mannitol in seaweed and kelp was higher, and the content of mannitol in the washing liquid washed by seaweed was up to 2%, and the washing liquid of kelp was about 1.5%.

acidity

Take 5.0g of this product, add 50ml of water to dissolve, add 3 drops of phenolphthalein indicator solution and 0.02 ml of sodium hydroxide titration solution (0.30 mol/L), which should be pink.

clarity and color of solution

take 1.5g of this product, Add 10ml of water to dissolve, the solution should be clear and colorless; If it is turbid, it should not be more concentrated compared with No. 1 turbidity standard solution (General rule 0902 first method).

Related substances

take this product, add water to dissolve and dilute to make a solution containing 50mg per lml as a test solution; Take lml for precision measurement, put it in a 100ml measuring flask, dilute it with water to the scale, as a control solution; Another mannitol and sorbitol each 0.5G, put in a 100ml measuring flask, add water to dissolve and dilute to the scale, as a system applicable solution. According to the high performance liquid chromatography (General 0512) test, a strong cation calcium type exchange column (or a column with equivalent separation efficiency) with sulfonated crosslinked styrene divinylbenzene copolymer as the filler, and water as the mobile phase, the flow rate was 0.5ml per minute, the column temperature was 80°C, the refractive index detector, and the detection temperature was 55°C. The system applicable solution 20u1 was injected into the liquid chromatograph, and the chromatogram was recorded. The resolution between the mannitol peak and the sorbitol peak should be greater than 2.0. 20ul of the test solution and the control solution were respectively injected into the human liquid chromatograph, and the chromatogram was recorded to 2 times of the retention time of the main component peak. If there are impurity peaks in the chromatogram of the test solution, the sum of each impurity peak area shall not be more than 2 times (2.0%) of the main peak area of the control solution. The chromatogram of the test solution is 0.05 times smaller than the main peak area of the control solution.

reducing sugar

Take 5.0g of this product, put it in an Erlenmeyer flask, add 25ml of water to dissolve, add copper citrate solution (take 25g of copper sulfate, 50g of citric acid and 114g of anhydrous sodium carbonate, add 1000ml of water to dissolve, 20ml, heated to boiling, keep boiling for 3 minutes, quickly cool, add 2.4%(V/V) glacial acetic acid solution 0.025 ml and 20.0 mol/L Iodine titration solution ml, shake well, add 6%(V/V) hydrochloric acid solution 25ml (precipitate should be completely dissolved. If there is any precipitate, continue to add the hydrochloric acid solution until the precipitate is completely dissolved), titrate with sodium thiosulfate titration solution (0.05mol/L), and add 1 ml of starch indicator solution near the end point, titration was continued until the blue color disappeared. The volume of sodium thiosulfate titrant (0.05mol/L) consumed shall not be less than 12.8.

chloride

take 2.0g of this product and check it according to law (General rule 0801). Compared with the control solution made of 6.0ml of standard gasification sodium solution, it should not be more concentrated (0.003%).

sulfate

take 2.0g of this product and check it according to law (General rule 0802). Compared with the control solution made of 0.01% of standard potassium sulfate solution, it should not be more concentrated ().

oxalate

take this product l. Add 3 drops of ammonia test solution and 1 ml of gasified calcium test solution, shake well, heat in water bath for 15 minutes, then take out and cool; if turbidity occurs, and sodium oxalate solution [take sodium oxalate 0.1523g, put in 1000ml measuring flask, add water to dissolve and dilute to the scale, shake, each lml is equivalent to 0.1 mg of oxalate (C204)] 0.02% ml of control solution prepared by the same method should not be more concentrated ().

loss on drying

take this product, dry to constant weight at 105°C, weight loss shall not exceed 0.5% (General rule 0831).

ignition residue

not more than 0.1% (General rule 0841).

Heavy metals

take 2.0g of this product, add 23ml of water to dissolve, add 2ml of acetate buffer (pH 3.5), and check according to law (General rule 0821 first law), containing heavy metals shall not exceed 10 parts per million.

arsenic salt

take this product l. Add 10ml of water to dissolve, add 5ml of dilute sulfuric acid and 0.5ml of potassium bromide bromide solution, and heat on a water bath for 20 minutes, keep a slight excess of bromine (if necessary, add potassium bromide bromide solution Dropwise), and add the water of evaporation at any time, cool, add hydrochloric acid 5ml and water to make 28ml, inspection according to law (General Principles 0822 first law), shall comply with the provisions (0.0002%).

 

Our company specializes in processing and selling chemical raw materials, chemical products, pharmaceutical intermediates, veterinary medicine intermediates, dye intermediates, pigments, cosmetics raw materials and chemical reagents,  

Our company has a number of sales team, service and information feedback vertical integration of a sound marketing network, products are sold throughout the country and exported to South Asia, Europe, America, Africa and other more than 20 countries and regions.  

Companies adhering to the "pursuit of quality, innovation and development" business philosophy, to serve as a foundation, for the survival by the quality, seek development by science and technology, adhere to quilty comes first,fair price,good sense of customer service and responsibility. in the future hebei Nengqian import and export trade Co.,Ltd will always hold "integrity, innovation" business philosophy, to achieve honesty management, on the way of specialization, internationalization,  Keep moving!  

 

 

 

 

 

Our advantages: 

1, High quality with competitive price:

1) Standard:BP/USP/EP/Enterprise standard

2) All Purity≥99%

3) We are manufacturer and can provide high quality products with factory price.

 2, Fast and safe delivery

1) Parcel can be sent out in 24 hours after payment.Tracking number available

2) Secure and discreet shipment.Various transportation methods for your choice.

3) Customs pass rate ≥99%

4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe,

and we have stock in there for transferring.

Product Packaging：

1) 1kg/bag (1kg net weight, 1.1kg gross weight, packed in an aluminum foil bag)

2) 25kg/drum (25kg net weight, 28kg gross weight; Packed in a cardboard-drum with two plastic-bags inside; Drum Size: 510mm high, 360mm diameter)

 Storage：

Stored in a cool and dry well-closed container. Keep away from moisture and strong light/heat.

Delivery：

Usually within3-5 working days after full payment.

transport：

EMS,DHL, TNT, UPS ,FEDEX, BY AIR, BY SEA

DHL Express, FedEx and EMS for quantity less than 50KG, usually called as DDU service; 

Sea shipping for quantity over 500KG; And air shipping is available for 50KG above;

For high value products, please select air shipping and DHL express for safe;

Our Service:
1. Fast Delivery: We can delivery within 24 hours upon receipt of your payment.
2. Quality can be promised. Hot sell to Worldwide.
3. Payment Terms: T/T,, t/t
4. Free Sample available at any time.
5. Tracking your order at any time. Inform your order's further new situation at any time.
6. Package: Professional packing with professional materials.

FAQ: 
1.Are you a trade company or factory   
We are a  factory with our own trading company.  

2.How do you control the quality   
Our factory is equipped with professional technicians to control quality, out inspectors take sample for testing every 2 hours to ensure the quality of our production. We also accept BV, SGS or any other Third-party inspection.   

3.How long is lead time   
We deliver goods within 3 days for small order, 7-10 days for bulk order.   

4. Where is your factory located  How can I visit the factory   
 Our factory located in HEBEI, China.

5.Can i get some samples  
  Yes, we can supply free sample, but the shipping cost be paid by our customers. 

6.How to start orders or make payments  
  Proforma invoice will be sent first after confirmation of order, enclosed our bank information.Payment by T/T,  

7. How to confirm the Product Quality before placing orders  
  You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. 
8. How long is lead time

We deliver goods within 3 days for small order, 7-10 days for bulk order.

 

9. How do you treat quality complaint

  First of all, our quality control will reduce the quality problem to near zero. If there is a realquality problem caused by us, we will send you free goods for replacement or refund your loss.