Dipyrone 68-89-3

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Product introduction:

Metamizole sodium Usage And Synthesis

	Dipyrone is a water soluble pyrazolone derivative available in oral, rectal and injectable forms. It has analgesic, antipyretic, antispasmodic, and anti-inflammatory properties. Dipyrone is used most commonly to treat severe pain, particularly, for pain associated with smooth muscle spasm or colic affecting the gastrointestinal, biliary or urinary tracts. It is useful for fever that is refractory to other treatment. Because of the risk of serious adverse effects, such as agranulocytosis, its use is justified only in serious situations where no alternative is available or suitable.
	Alias: dipyrone, NOVALGIN; Noramidopyrine, Metamizole sodium,metamizole Property: This product is white or yellow-white crystal or crystalline powder, odorless, slightly bitter taste, soluble in water. Action: Dipyrone is the derivative of aminopyrine, its has a significant effect of antipyretic analgesia. The antipyretic effect of it is three times as aminopyrine, the analgesic effect is similar to that of aminopyrine. Process vivo: Easily absorbed orally, mainly metabolized by the liver and excreted of renal Indications: It is mainly used for cooling, acute arthritis, headache, rheumatic neuralgia, toothache and muscle pain etc. Dosage Oral or intranasal administration. For oral, the adult should take 0.5g of the medicine and three times a day, the amount of the child is 8-10mg/ kg, the number of the times is according to the necessary. For intranasal, the child under 5 years old can take 1-2drops for each nostril, can take the medicine another time if necessary,for the patient above 5 years old increase the dosage appropriately. Note 1, The dosage should be controled strictly to prevent collapse. 2, The intramuscular injection can cause atrophy and erosion to the local muscle, it is abandoned now. 3, The patient who has a allergy to the praziquantel can not use the dipyrone 4, It not suitable for a long-term application, Please pay attention to the granulocytes. Specification Tablets:each table is weight for 0.25g or 0.5g; Injection: each ingection has the specification of 0.25g/1ml or 0.5g/2ml; Drops: solution with the concentration of 10%~20%
	1, The side effects contain the allergies, exhaustion, leukopenia, thrombocytopenia even the severe aplastic anemia. 2, Some people may also suffering the nephrotoxicity and gastrointestinal bleeding after they take the dipyrone.The most serious side effect is lethal agranulocytosis.
	It has the effect of detoxification, analgesic and anti-rheumatic etc and mainly used for cooling, but also can be applied to cure the acute arthritis, rheumatic pain, muscle pain and headache etc.
	Category Toxic Chemicals Acute toxicity For oral – the lethal dose for rat LD50: 3000 mg/kg; For oral – the lethal dose for mouse LD50: 2891 mg/kg Toxicity grading Moderately toxic Flammability hazard characteristic It is combustible and can produce the toxic fumes contained nitrogen oxides, sulfur oxides and sodium oxide during the combustion Storage Characteristic The storeroom should be airy, low-temperature and dried. Extinguishing agent Dry powder, foam, sand, carbon dioxide, water mist
	[1] Micha Levy, Ester Zylber-Katz and Bernd Rosenkranz, Clinical Pharmacokinetics of Dipyrone and its Metabolites, Clinical Pharmacokinetics, 1995, vol. 28, 216-234 [2] JE Edwards, F. Meseguer, CC Faura, RA Moore and HJ McQuay, Single-dose dipyrone for acute postoperative pain, Cochrane Database Syst Rev., 2010, vol. 9, CD003227
Chemical Properties	solid
Uses	A non-steroidal anti-inflammatory drug that, when coadministered with morphine, potentiates its antinociceptive action and delays the development of tolerance. Dipyrone is a relatively selective inhibitor of cyclooxygenase-3 (COX-3), with lower activity against COX-1 and no activity against COX-2. Blocks PGE2-induced hyperalgesia in several models.
Uses	Dipyrone is a non-steroidal anti-inflammatory drug that, when coadministered with morphine, potentiates its antinociceptive action and delays the development of tolerance. Dipyrone is a relatively sel ective inhibitor of cyclooxygenase-3 (COX-3), with lower activity against COX-1 and no activity against COX-2. Dipyrone blocks PGE2-induced hyperalgesia in several models.
Uses	Methamizole sodium has expressed analgesic and fever-reducing properties and poorly expressed anti-inflammatory action, and is very convenient in cases where high concentrations of drug need to be quickly reached. Methamizole sodium is used for relieving pain of various origins (renal and biliary colic, neuralgia, myalgia, trauma, burns, headaches, and toothaches). Use of this drug may cause allergic reactions, and long-term use may cause granulocytopenia.
Definition	ChEBI: An organic sodium salt of antipyrine substituted at C-4 by a methyl(sulfonatomethyl)amino group, commonly used as a powerful analgesic and antipyretic.
Brand name	Diprofarn (Farmitalia, Societa Farmaceutici Italia, Italy); Novaldin (Sterling Winthrop);Abalgine;Acabel compositum;Acefalgin;Acrobal;Acrogesico;Adolkin;Algia-nil;Alginodia compose;Algisedal;Algobuscopan;Algopriv;Algopyriv;Alkozin;Amiglan;Aminocid;Amitralil;Ampi tumisan;Anadex;Analcedor;Analject;Anarinyl;Anchrina;Anespas cpto;Angiter;Ankaljin;An-t;Apasmo;Arantil;Arquidon;Artritex;Ascorbalgine;Ascortin;Aseptobron;Atecilina;Atn-020/2;Avafortan;Ayoral;Bayer 1387;Bebealjin;Bebigut;Belatropin;Belflex/2;Beneurin;Bexopirona;Biogamma2;Biotangin;Bipasmin compuesto;Bort;Bristacilia;Britercina;Bromalgin;Bromalgon;Broncofenil;Broncolysin;Bucarboxal;Buscapina comp.;Buscapina compuesto;Buscapina compuestum;Buscol compositum;Buscopan composto;Buscopan compostum;Buscopina compostum;Butalgine;Butylpan;Calgayan-c;Calmetron;Camizol;Causalon;Cessantyl;Chini-med;Cintaverin compuesto;Clizim;Clofexan;Codalgin;Codasal injetavel;Colgenol;Comaril 5000;Corilin pediatric;Cortempirol;Cortitracin;Cronopen balsamico;Deltricin;Devalgin;Dexa butarin;Di-bal-rone;Dimethedon;Dinopirina;Dioxadol;Dipirona;Diprofarm;Dipyrivo;Dispalgine;Divarin;Divarmin;Do-ba-rone;Dolatets;Dolazon;Dolemicin;Dolispasmo;Dolo adamon;Dolo baralgine;Dolo buscopan;Dolo nerv;Dolo neurobion forte;Dolo pangavit;Dolo raptalgin;Dolo spasuret;Dolojudolor;Dolo-neurobion;Dolopirina;Doloscopin;Dopiral;Dorflex merrell;Dorlisin;Doron;Dorscopena;D-pron;Dumalgin;Duralnordin;Dya-tran;Edgartet;Eespanal;Enzipan combinado;Espasfher;Espasmir;Espasmo-cibalgina;Espasmoqual;Espasmotex;Espasmoviral;Espyre;Farbinol;Flogolisin;G.r. ulix compuesto;Genservet;Gentil;Geralgine;Glutisal;Greplicina belsa;H 116;H 117;H 118;Hagalgin;Hasain;Indextron;Influbene;Kb-502;Kefren;Kesan;Killgrip;Kipyrone;Kitax alpha;Kitax n;Konitan;Labymetacincpo;Lactmicina;Lagalgine;Lamprcsnum;Lapalgine;Larq 731;Lasain;Lavaciclina;Levapa;Levismon;Lisalgil;Magdor;Magnalsa;Magnemidon;Mapir;Mecoten;Megal;Melpen;Menalgine;Mialgan;Minalgine;Minoval;Miocitalgan;Nadalgine;Naftalgin;Naltrium;Napasone;Nartate;Natralgin;Natric;Neo-melubrim;Neo-melubrina;Neo-melubrine;Neo-oxipen;Neosal-n;Neosoldina;Neuro-fortamin;Nisidina;Nlo conicilina balsamica;Nobelgin;Nolotil composirum;Notermin;Novacid;Novalcina;Novalgetol;Novalgin quinine;Novalgina;Novalgine;Nova-lyseen;Novamidazofen;Novamidazophen;Novamideazophene;Novaminophenazone;Novaminsulfon ratiopharm;Novaminsulfone sodium;Novaminsulfonium;Novaminsulfonum;Novaminsulton;Novazolon dexametasona;Noveltex;Novemida;Novemina;Novil;Oftlamin;Orphalginen;Ortopirona;Oxiquiunazine;Pabron gold;Panalvon;Patalgin;Pentrodin;Phanalgin;Pharmalgine;Porbiot;Pplan 2500;Probaphen;Prodol;Prydonnal;Pydirone;Pyralgine;Pyrilgin;Pyriligin;Pyrisan;Quarelin;Reflex rectal;Relexal compuesto;Repriman;Resquim;Rheuma-spalt;Ridol;Rumalisine;Rupalgin;Santeprednisan a;Sebon;Sedabel;Sedarel;Sedarene;Sedazepane;Selpiran;Sertalanalgesico;Severen;Sinalgex;Sintaverin;Sinvirol;Spasdolsom;Spaslar;Spasmalgon;Spasmium-comp.;Spasmizol;Spasmodor;Spasmopyralgin;Spasmothil;Sufonovin;Sulfonovin;Supadol;Supergine;Surpyrine;Tanper;Tapal;Tega-pyrone;Tempil;Tepal;Termonil;Tetrabal-hosbon;Tetraspasmil;Tiadexol;Tiartan;Toloxin andromaco;Trenteron;Triartan;Trinalgen.
World Health Organization (WHO)	Metamizole sodium, a pyrazolone derivative with analgesic, antipyretic and antinflammatory activity, was introduced in 1921 and has since been widely available in over-the-counter products. By the early 1970s its use had been associated, as with some other pyrazolones, with serious and sometimes fatal adverse reactions, notably cases of blood dyscrasias including agranulocytosis, which led to its withdrawal by some regulatory authorities. Although preparations of metamirole sodium are prohibited in certain countries, they remain widely available in others and, in some cases, in over-the-counter products.
Safety Profile	Poison by subcutaneous route. Moderately toxic by several other routes. An experimental teratogen. Other experimental reproductive effects. Human mutation data reported. Questionable carcinogen with experimental neoplastigenic data. See also SULFONATES. When heated to decomposition it emits very toxic fumes of NOx,, Na2O, and SOx,.
Synthesis	Methamizole sodium, 1-phenyl-2,3-dimethyl-4-methylaminopyrazolone-5-N-sodium methansulfonate (3.2.16), is synthesized in a multi-stage synthesis from acetoacetic ester and phenylhydrazine. Their reaction leads to the formation of 1-phenyl- 3-methylpyrazolone-5 (3.2.9). Methylation of this product with methyl iodide gives 1-phenyl- 2,3-dimethylpyrazolone-5 (3.2.10). This compound is used independently in medicine as a fever-reducing and anti-inflammatory analgesic under the name antipyrin. It undergoes nitrozation by sodium nitrite in an acidic medium, forming 1-phenyl-2,3-dimethyl-4- nitrozopyrazolone-5 (3.2.11). Reduction of the nitrous derivative (3.2.11) by different reducing agents leads to the formation of 1-phenyl-2,3-dimethyl-4-aminopyrazolone-5 (3.2.12). This product is reacted with benzaldehyde, forming an easily separable crystalline 1-phenyl- 2,3-dimethyl-4-benzylidenaminopyrazolone-5 (3.2.13), which is methylated at the imine atom of nitrogen by dimethylsulfate, giving a quaternary salt (3.2.14). Hydrolysis of the resulting salt gives 1-phenyl-2,3-dimethyl-4-methylaminopyrazolone-5 (3.2.15). Treating the product with a water solution of a mixture of sodium bisulfite and formaldehyde leads to the formation of 1-phenyl-2,3-dimethyl-4-methylaminopyrazolone-5-N-sodium methanesulfonate (3.2.16), the desired sodium methamizole [72¨C75].

 

 

Our company specializes in processing and selling chemical raw materials, chemical products, pharmaceutical intermediates, veterinary medicine intermediates, dye intermediates, pigments, cosmetics raw materials and chemical reagents,  

Our company has a number of sales team, service and information feedback vertical integration of a sound marketing network, products are sold throughout the country and exported to South Asia, Europe, America, Africa and other more than 20 countries and regions.  

Companies adhering to the "pursuit of quality, innovation and development" business philosophy, to serve as a foundation, for the survival by the quality, seek development by science and technology, adhere to quilty comes first,fair price,good sense of customer service and responsibility. in the future hebei Nengqian import and export trade Co.,Ltd will always hold "integrity, innovation" business philosophy, to achieve honesty management, on the way of specialization, internationalization,  Keep moving!  

 

 

 

 

 

Our advantages: 

1, High quality with competitive price:

1) Standard:BP/USP/EP/Enterprise standard

2) All Purity≥99%

3) We are manufacturer and can provide high quality products with factory price.

 2, Fast and safe delivery

1) Parcel can be sent out in 24 hours after payment.Tracking number available

2) Secure and discreet shipment.Various transportation methods for your choice.

3) Customs pass rate ≥99%

4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe,

and we have stock in there for transferring.

Product Packaging：

1) 1kg/bag (1kg net weight, 1.1kg gross weight, packed in an aluminum foil bag)

2) 25kg/drum (25kg net weight, 28kg gross weight; Packed in a cardboard-drum with two plastic-bags inside; Drum Size: 510mm high, 360mm diameter)

 Storage：

Stored in a cool and dry well-closed container. Keep away from moisture and strong light/heat.

Delivery：

Usually within3-5 working days after full payment.

transport：

EMS,DHL, TNT, UPS ,FEDEX, BY AIR, BY SEA

DHL Express, FedEx and EMS for quantity less than 50KG, usually called as DDU service; 

Sea shipping for quantity over 500KG; And air shipping is available for 50KG above;

For high value products, please select air shipping and DHL express for safe;

Our Service:
1. Fast Delivery: We can delivery within 24 hours upon receipt of your payment.
2. Quality can be promised. Hot sell to Worldwide.
3. Payment Terms: T/T,, t/t
4. Free Sample available at any time.
5. Tracking your order at any time. Inform your order's further new situation at any time.
6. Package: Professional packing with professional materials.

FAQ: 
1.Are you a trade company or factory   
We are a  factory with our own trading company.  

2.How do you control the quality   
Our factory is equipped with professional technicians to control quality, out inspectors take sample for testing every 2 hours to ensure the quality of our production. We also accept BV, SGS or any other Third-party inspection.   

3.How long is lead time   
We deliver goods within 3 days for small order, 7-10 days for bulk order.   

4. Where is your factory located  How can I visit the factory   
 Our factory located in HEBEI, China.

5.Can i get some samples  
  Yes, we can supply free sample, but the shipping cost be paid by our customers. 

6.How to start orders or make payments  
  Proforma invoice will be sent first after confirmation of order, enclosed our bank information.Payment by T/T,  

7. How to confirm the Product Quality before placing orders  
  You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. 
8. How long is lead time

We deliver goods within 3 days for small order, 7-10 days for bulk order.

 

9. How do you treat quality complaint

  First of all, our quality control will reduce the quality problem to near zero. If there is a realquality problem caused by us, we will send you free goods for replacement or refund your loss.