Bortezomib Bortezomib Powder CAS 179324-69-7
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Product Name: Bortezomib
CAS: 179324-69-7
MF: C19H25BN4O4
MW: 384.24
EINECS: 605-854-3
Melting point: 122-124°C
Boiling point: 614.8±55.0 °C
Density: 1.214
Storage temp.: Inert atmosphere,Room Temperature
Appearance: White Powder
Description:
Bortezomib, a modified dipeptidyl boronic acid, is a therapeutic proteasome inhibitors used for the treatment of cancers. It is indicated for the treatment of relapsed multiple myeloma and mantle cell lymphoma. It is capable of inhibiting the mammalian 26S proteasome, which is important in regulating the intracellular concentration of specific proteins to maintain homeostasis within cells. The disruption of 26S proteasome function disrupts normal cellular homeostasis, leading to cytotoxic effect on various kinds of cancer cells.
Use:
Bortezomib is the first proteasome inhibitor to be approved b the US FDA for multiple myeloma, a blood cancer. A reversible inhibitor of the 26S proteasome-a barrel-shaped multiprotein particle found in the nucleus and cytosol of all eukaryotic cells.
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