1-beta-D-Arabinofuranosylcytosine hydrochloride 69-74-9

Details:

Product introduction:

Molar Mass	279.68
Melting Point	197-198°C(lit.)
Boling Point	545.7°C at 760 mmHg
Flash Point	283.8°C
Vapor Presure	3.5E-14mmHg at 25°C
Appearance	White crystal
Color	White to off-white
Storage Condition	2-8°C
Stability	Stable. Combustible. Incompatible with strong oxidizing agents.
Sensitive	Easily absorbing moisture
MDL	MFCD00012839
Physical and Chemical Properties	This product is white fine needle-like crystal or crystalline powder. Odorless, easily soluble in water, slightly soluble in methanol and ethanol, slightly soluble in ether. mp189-195 C (decomposition). The specific rotation should be 127 °- 133 °(10 mg/ml). Acid and alkaline aqueous solution hydrolysis to produce uridine Arabinoside, the most stable pH value of 6.9.
Use	For acute leukemia, also for head and neck squamous cell carcinoma, external for viral keratitis and epidemic conjunctivitis

Related substances

• take an appropriate amount of this product, precisely weigh, add water to dissolve and quantitatively dilute to make a solution containing 5mg per lml, as a test solution; Take an appropriate amount of cytarabine hydrochloride reference, precisely weigh, water was added to dissolve and quantitatively diluted to prepare a solution containing 5% per 1 ml as a control solution. Silica gel bonded with eighteen alkyl silanes as fillers (0512 X 4.6mm mm, 5um) as determined by high performance liquid chromatography (General 7.0); (Take 0.02mol/L sodium dihydrogen phosphate solution and 0.02mol/L disodium hydrogen phosphate solution equal volume mixing, with 0.1 mol/L sodium hydroxide solution or 0.1 mol/L phosphoric acid solution to adjust the pH value to 7.0)-methanol (98:2) as mobile phase A, phosphate buffer (pH 7.0)-methanol (70:30) as mobile Phase B, the gradient elution was carried out as follows; The detection wavelength was 254mn. In addition, appropriate amounts of cytarabine hydrochloride and uridine were dissolved in water and diluted to prepare solutions containing 5mg and 20ul of each 1 ml as the system applicable solution. 20UL was injected into the liquid chromatograph, and the chromatographic system was adjusted. The resolution of cytarabine peak and uridine peak should meet the requirements. 2 Ou1 of the test solution and the reference solution were respectively injected into the liquid chromatograph, and the chromatograms were recorded. The relative retention times of uracil peak, uridine peak and uridine peak to cytarabine peak are about 0.55,1- 14 and 1.62, respectively, the correction factors of uridine peak and uridine arabinoside peak for cytarabine peak were 2.9, 1.72 and 1.54, respectively. The correction factors for chromatographic peaks with relative retention times of about 0.38 and 0.43 for cytarabine peak were both 1.72, the correction factors of other impurity peaks were calculated as 1.1.
• if there are impurity peaks in the chromatogram of the test solution, the following formula shall be calculated: uracil and uridine shall not exceed 0.1%; Uridine arabinoside shall not exceed 0.3%; Other individual impurities shall not exceed 0.1%; the sum of all impurities shall not exceed 0.3%.

residual solvent

take about 0.2g of this product, weigh it accurately, place it in the top empty bottle, add 5ml of water accurately to dissolve, Seal, shake, and use it as a test solution; take the appropriate amount of methanol and ethanol, precisely weigh, dilute with water to make a solution containing about 120ug of methanol and 200ug of ethanol in each lml respectively. Take 5ml of the precise amount, place it in the top empty bottle, and seal it, as a reference solution; Take the appropriate amount of methyl ethyl ketone and isopropyl alcohol separately, put in the same measuring flask, dilute with water to make the solution containing about lOug in each lml, take 5ml, put in the top empty bottle, Seal, as a system suitability solution. According to the determination method of residual solvent (General 0861 second method), using polyethylene glycol (or polar similar) as the stationary liquid capillary column; The initial temperature is 60 degrees C, maintain 6 minutes, increase the temperature to 100°C at a rate of 8°C per minute for 20 minutes; The inlet temperature was 200°C; The detector temperature was 230°C; The headspace bottle equilibrium temperature was 80°C and the equilibrium time was 30 minutes. The system applicable solution was sampled by Headspace injection, and the chromatographic system was adjusted. The resolution of methyl ethyl ketone peak and isopropanol peak should meet the requirements. The test solution and the reference solution were injected by Headspace, and the chromatograms were recorded. According to the external standard method, the residual amount of methanol and ethanol should be calculated by Peak area, and the requirements should be met.

loss on drying

take this product, put it in a phosphorus pentoxide dryer, and dry it under reduced pressure to constant weight. The weight loss shall not exceed 0.5% (General rule 0831).

ignition residue

take l.Og of this product and check it according to law (General rule 0841). The residue left shall not exceed 0.5%.

Heavy metals

The residue left under the item of taking the ignition residue shall not contain more than 10 parts per million of heavy metal when examined by law (General Principles 0821, Law II).

Cytarabine hydrochloride for injection

Authoritative Data Verified Data

This product is a sterile lyophilized product of cytarabine hydrochloride. Cytarabine hydrochloride (C3H13N305 • HCl) should be included in 93.0% to 107.0% of the labeled amount, based on the average loading.

trait

This product is white loose lumps or powder.

identification

The same results were obtained according to the tests (1), (2) and (4) for the identification of cytarabine hydrochloride.

examination

• the acidity of this product is dissolved in water and diluted to prepare a solution containing cytarabine hydrochloride 10 mg per lml, which is measured according to law (General rule 0631). The pH value should be 4.0~6.0.
• clarity of solution take this product, add water to be dissolved and diluted to make a solution containing 20mg per 1 ml, and the solution should be clear; If it is turbid, compared with No. 1 turbidity standard solution (General Principles 0902 first method), shall not be more concentrated.
• Related substances the contents of this product are dissolved in water and diluted quantitatively to prepare a solution containing 5mg cytarabine hydrochloride per 1 ml, which is used as a test solution for determination according to the method under the item of related substances of cytarabine hydrochloride, the requirements shall be met.
• the moisture content of this product shall not exceed 0832 as determined by the method for determination of moisture (General rule 3.0%, first method 1).
• abnormal toxicity: take this product, add sodium chloride injection to dissolve and dilute it to prepare a solution containing 30mg cytarabine hydrochloride per 1 ml, check according to law (General rule 1141), and give it by intravenous injection, the requirements shall be met.
• bacterial endotoxin this product, according to the law inspection (General 1143), each 1 mg of cytarabine hydrochloride containing endotoxin amount should be less than 0.050EU.
• others should comply with the relevant provisions under injection (General 0102).

Content determination

take 5 bottles of this product, weigh the contents accurately respectively, add appropriate amount of water to dissolve the contents in each container, transfer the contents to the same appropriate measuring bottle, dilute with water to the scale, shake well, take an appropriate amount of precision, quantitative dilution with water to make each lml containing cytarabine hydrochloride 0. The 1 mg solution was obtained as a test solution by measurement according to the method described under cytarabine hydrochloride.

category

Same as cytarabine hydrochloride.

specification

(l)50mg (2)100mg (3)0.3g (4)0.5g

storage

light shielding, closed, stored in cold place.

 

Our company specializes in processing and selling chemical raw materials, chemical products, pharmaceutical intermediates, veterinary medicine intermediates, dye intermediates, pigments, cosmetics raw materials and chemical reagents,  

Our company has a number of sales team, service and information feedback vertical integration of a sound marketing network, products are sold throughout the country and exported to South Asia, Europe, America, Africa and other more than 20 countries and regions.  

Companies adhering to the "pursuit of quality, innovation and development" business philosophy, to serve as a foundation, for the survival by the quality, seek development by science and technology, adhere to quilty comes first,fair price,good sense of customer service and responsibility. in the future hebei Nengqian import and export trade Co.,Ltd will always hold "integrity, innovation" business philosophy, to achieve honesty management, on the way of specialization, internationalization,  Keep moving!  

 

 

 

 

 

Our advantages: 

1, High quality with competitive price:

1) Standard:BP/USP/EP/Enterprise standard

2) All Purity≥99%

3) We are manufacturer and can provide high quality products with factory price.

 2, Fast and safe delivery

1) Parcel can be sent out in 24 hours after payment.Tracking number available

2) Secure and discreet shipment.Various transportation methods for your choice.

3) Customs pass rate ≥99%

4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe,

and we have stock in there for transferring.

Product Packaging：

1) 1kg/bag (1kg net weight, 1.1kg gross weight, packed in an aluminum foil bag)

2) 25kg/drum (25kg net weight, 28kg gross weight; Packed in a cardboard-drum with two plastic-bags inside; Drum Size: 510mm high, 360mm diameter)

 Storage：

Stored in a cool and dry well-closed container. Keep away from moisture and strong light/heat.

Delivery：

Usually within3-5 working days after full payment.

transport：

EMS,DHL, TNT, UPS ,FEDEX, BY AIR, BY SEA

DHL Express, FedEx and EMS for quantity less than 50KG, usually called as DDU service; 

Sea shipping for quantity over 500KG; And air shipping is available for 50KG above;

For high value products, please select air shipping and DHL express for safe;

Our Service:
1. Fast Delivery: We can delivery within 24 hours upon receipt of your payment.
2. Quality can be promised. Hot sell to Worldwide.
3. Payment Terms: T/T,, t/t
4. Free Sample available at any time.
5. Tracking your order at any time. Inform your order's further new situation at any time.
6. Package: Professional packing with professional materials.

FAQ: 
1.Are you a trade company or factory   
We are a  factory with our own trading company.  

2.How do you control the quality   
Our factory is equipped with professional technicians to control quality, out inspectors take sample for testing every 2 hours to ensure the quality of our production. We also accept BV, SGS or any other Third-party inspection.   

3.How long is lead time   
We deliver goods within 3 days for small order, 7-10 days for bulk order.   

4. Where is your factory located  How can I visit the factory   
 Our factory located in HEBEI, China.

5.Can i get some samples  
  Yes, we can supply free sample, but the shipping cost be paid by our customers. 

6.How to start orders or make payments  
  Proforma invoice will be sent first after confirmation of order, enclosed our bank information.Payment by T/T,  

7. How to confirm the Product Quality before placing orders  
  You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. 
8. How long is lead time

We deliver goods within 3 days for small order, 7-10 days for bulk order.

 

9. How do you treat quality complaint

  First of all, our quality control will reduce the quality problem to near zero. If there is a realquality problem caused by us, we will send you free goods for replacement or refund your loss.