1-Arg-5-Phe-7,9-Trp-11-Leu-substance P D-Arg(10)-D-Phe(5)-D-Trp(7,9)-Leu(11)-SP
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[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P is a broad spectrum neuropeptide inverse agonist and antagonist. It acts as a full inverse agonist for the ghrelin receptor (EC50 = 5.2 nM) and antagonist at tachykinin, bradykinin, CCK and bombesin receptors. It induces apoptosis and inhibits cancer cell growth in vitro.
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