Atrial Natriuretic Peptide (ANP) (1-28), rat

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Purity: ≥95%

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Atrial natriuretic factor (1-28) (rat) rANP

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Appearance:White or Off-white Lyophilized Powder
Application:Vasodilator Agents
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Storage:Store in a cool and dry place and at 2-8°C for short term (days to weeks) or store at -20°C for long term (months to years)
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Atrial natriuretic factor (1-28) (rat) is a 28 amino acid peptide corresponding to the rat protein sequence. It is an endogenous peptide synthesized in myoendocrine cells of the heart from which it is released into the circulation. It has effects on the renal and cardiovascular systems that decrease vasoconstriction, increase sodium excretion and inhibit renin secretion. It decreases plasma renin activity and cAMP levels in anesthetized rats and increases cGMP levels at 8 μg/kg. It also inhibits the arginine vasopressin-induced increase in mean arterial blood pressure in spontaneously hypertensive and control rats when administered intracerebroventricularly at a dose of 150 ng. It produces diuretic, natriuretic and vasodilatory effects through stimulation of guanylate cyclase-linked NPR-A receptors. It plays an important role in blood volume and blood pressure regulation.

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