H-Pro-Asn-Thr-Cys-Glu-Ile-Cys-Ala-Tyr-Ala-Ala-Cys-Thr-Gly-Cys-OH (Disulfide bridge: Cys4-Cys12, Cys7-Cys15) L-prolyl-L-asparagyl-L-threonyl-L-cysteinyl-L-alpha-glutamyl-L-isoleucyl-L-cysteinyl-L-alanyl-L-tyrosyl-L-alanyl-L-alanyl-L-cysteinyl-L-threonyl-glycyl-L-cysteine (4->12),(7->15)-bis(disulfide)
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Guanylin (rat, mouse) is an endogenous intestinal guanylate cyclase activator that stimulates the production of cGMP and causes secretory diarrhea. Therefore, it may regulate intestinal fluid and electrolyte absorption in intestines.
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