K 41498

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Purity: >98%

Keywords

D-Phenylalanyl-L-histidyl-L-leucyl-L-leucyl-L-arginyl-L-lysyl-L-norleucyl-L-isoleucyl-L-α-glutamyl-L-isoleucyl-L-α-glutamyl-L-lysyl-L-glutaminyl-L-α-glutamyl-L-lysyl-L-α-glutamyl-L-lysyl-L-glu...

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Appearance:Off-white Powder
Application:For research use only.
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Storage:Store at -20°C
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K 41498 is a potent and highly selective CRF2 receptor antagonist. Its Ki values are 425, 0.66 and 0.62 nM for human CRF1, CRF2α and CRF2β receptors respectively. It prevents sauvagine-stimulated cAMP accumulation in hCRF2α- and hCRF2β-expressing cells. It blocks urocortin-induced hypotension following systemic administration in rats in vivo and is used to treat hypertension in rodents.

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