RC-100 Cyclo(-Gly-Ile-Cys-Arg-Cys-Ile-Cys-Gly-Arg-Gly-Ile-Cys-Arg-Cys-Ile-Cys-Gly-Arg) (Disulfide bridge: Cys3-Cys16, Cys5-Cys14, Cys7-Cys12)
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Retrocyclin-1, a theta-defensin, is a circular octadecapeptide containing an internal trisulfide ladder. In addition to its antimicrobial activity, it has a significant in vitro ability to protect human cells from infection with the T- and M-tropic strains of HIV-1. Retrocyclin is a small molecule HIV-1 entry inhibitor.
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