H-Ser-Ala-Asn-Ser-Asn-Pro-Ala-Met-Ala-Pro-Arg-Glu-Arg-Lys-Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys-OH (Disulfide bridge: Cys17-Cys28) Somatostatin 1-28
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Somatostatin-28 (sheep) is derived from posttranslational cleavage of prosomatostatin, which in turn is derived from a larger precursor, preprosomatostatin. S-28 is an octacosapeptide first isolated from the duodenum of pigs. Unlike S-14, S-28 increases amylase secretion, cellular cyclic GMP and Ca2+ outfluxes in the guinea pig pancreatic acini.
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