(D-Lys(nicotinoyl)1,β-(3-pyridyl)-Ala3,3,4-dichloro-D-Phe5,Asn6,D-Trp7,9,Nle11)-Substance P H-D-Lys(nicotinoyl)-Pro-β-(3-pyridyl)-Ala-Pro-3,4-dichloro-D-Phe-Asn-D-Trp-Phe-D-Trp-Leu-Nle-NH2
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Spantide II is more effective as an antagonist of substance P than spantide I, but less effective in releasing histamine from mast cells. The neurotoxicity of Spantide II is negligible.
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